The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
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Title
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
Authors
Keywords
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Journal
LEUKEMIA
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-04-03
DOI
10.1038/s41375-019-0461-5
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Note: Only part of the references are listed.- Leflunomide: A promising drug with good antitumor potential
- (2018) Chunying Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2018) Marcus J. G. W. Ladds et al. Nature Communications
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- (2018) Dang Wu et al. HAEMATOLOGICA
- BCL-2 inhibition in AML: an unexpected bonus?
- (2018) Marina Konopleva et al. BLOOD
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- (2017) Romina Mancinelli et al. Oxidative Medicine and Cellular Longevity
- Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives
- (2017) Derek McCulloch et al. OncoTargets and Therapy
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- MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells
- (2016) B. N. Sheikh et al. BLOOD
- Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
- (2016) David B. Sykes et al. CELL
- Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression
- (2016) Suzan Ruijtenberg et al. CELL CYCLE
- O-GlcNAcylation: a bridge between glucose and cell differentiation
- (2016) Chao Sun et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Significance of oncogenes and tumor suppressor genes in AML prognosis
- (2016) Maria Kavianpour et al. TUMOR BIOLOGY
- A bead-based western for high-throughput cellular signal transduction analyses
- (2016) Fridolin Treindl et al. Nature Communications
- A little sugar goes a long way: The cell biology of O-GlcNAc
- (2015) Michelle R. Bond et al. JOURNAL OF CELL BIOLOGY
- Acute promyelocytic leukemia: where did we start, where are we now and the future
- (2015) C C Coombs et al. Blood Cancer Journal
- CREB phosphorylation at Ser133regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling
- (2014) Shaista Naqvi et al. BIOCHEMICAL JOURNAL
- On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses
- (2013) Hélène Munier-Lehmann et al. JOURNAL OF MEDICINAL CHEMISTRY
- Acute myeloid leukaemia in adults
- (2013) Felicetto Ferrara et al. LANCET
- Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML
- (2012) A. Sexauer et al. BLOOD
- The Increase inO-LinkedN-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Bothin Vitroandin Vivo
- (2012) Jessica Andrés-Bergós et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks
- (2012) Sandeep N. Shah et al. PLoS One
- Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
- (2011) D. Iliopoulos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characteristic increase in nucleocytoplasmic protein glycosylation by O -GlcNAc in 3T3-L1 adipocyte differentiation
- (2010) Katsunori Ishihara et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Leukemogenic transformation by HOXA cluster genes
- (2010) C. Bach et al. BLOOD
- The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor
- (2010) Edmond F. O'Donnell et al. PLoS One
- An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation
- (2009) Dimitrios Iliopoulos et al. CELL
- HOXA9 is required for survival in human MLL-rearranged acute leukemias
- (2008) J. Faber et al. BLOOD
- Biomarkers of apoptosis
- (2008) T H Ward et al. BRITISH JOURNAL OF CANCER
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