High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

How cardiolipin modulates the dynamics of respiratory complex I

(2019) Alexander Jussupow et al.   Science Advances

Mammalian Respiratory Complex I Through the Lens of Cryo-EM

(2019) Ahmed-Noor A. Agip et al.   Annual Review of Biophysics

Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I

(2019) Outi Haapanen et al.   Frontiers in Chemistry

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics

(2019) Etienne Galemou Yoga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of the Deactive State of Mammalian Respiratory Complex I

(2018) James N. Blaza et al.   STRUCTURE

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Redox-coupled quinone dynamics in the respiratory complex I

(2018) Judith Warnau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

(2018) Alfredo Cabrera-Orefice et al.   Nature Communications

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Cryo-EM structure of respiratory complex I at work

(2018) Kristian Parey et al.   eLife

Lipidomics by ultrahigh performance liquid chromatography-high resolution mass spectrometry and its application to complex biological samples

(2017) Alexander Triebl et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Mitochondrial complex I-linked disease

(2016) Richard J. Rodenburg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Distribution and dynamics of quinones in the lipid bilayer mimicking the inner membrane of mitochondria

(2016) Petri Kaurola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ndufs4 related Leigh syndrome: A case report and review of the literature

(2016) Juan Darío Ortigoza-Escobar et al.   MITOCHONDRION

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

Functional asymmetry and electron flow in the bovine respirasome

(2016) Joana S Sousa et al.   eLife

Partition, orientation and mobility of ubiquinones in a lipid bilayer

(2015) Vanesa Viviana Galassi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

New Perspectives on Proton Pumping in Cellular Respiration

(2015) Mårten Wikström et al.   CHEMICAL REVIEWS

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

Redox-induced activation of the proton pump in the respiratory complex I

(2015) Vivek Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I

(2015) Katarzyna Kmita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

(2015) Alan Brown et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterisation of the active/de-active transition of mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Cellular and animal models for mitochondrial complex I deficiency: A focus on the NDUFS4 subunit

(2013) Megan E. Breuer et al.   IUBMB LIFE

Shorthand notation for lipid structures derived from mass spectrometry

(2013) Gerhard Liebisch et al.   JOURNAL OF LIPID RESEARCH

Novel Insights into the Role of Neurospora crassa NDUFAF2, an Evolutionarily Conserved Mitochondrial Complex I Assembly Factor

(2013) B. Pereira et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Tightly-bound ubiquinone in the Escherichia coli respiratory Complex I

(2012) Michael Verkhovsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A constant and similar assembly defect of mitochondrial respiratory chain complex I allows rapid identification of NDUFS4 mutations in patients with Leigh syndrome

(2012) Z. Assouline et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Mitochondrial complex III stabilizes complex I in the absence of NDUFS4 to provide partial activity

(2011) M. A. Calvaruso et al.   HUMAN MOLECULAR GENETICS

Quinone binding and reduction by respiratory complex I

(2010) Maja A. Tocilescu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Lipid Data Analyzer: unattended identification and quantitation of lipids in LC-MS data

(2010) Jürgen Hartler et al.   BIOINFORMATICS

Evolution of Respiratory Complex I

(2010) Chui-ying Yip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance

(2010) M. M. Roessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

(2010) C. Hunte et al.   SCIENCE

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation