MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

(2016) Jiazhang Qiu et al.   NATURE

Silencing MARCH1 suppresses proliferation, migration and invasion of ovarian cancer SKOV3 cells via downregulation of NF-κB and Wnt/β-catenin pathways

(2016) Ying Meng et al.   ONCOLOGY REPORTS

E3 ubiquitin ligases as novel targets for inflammatory diseases

(2016) Santosh Kumar Goru et al.   PHARMACOLOGICAL RESEARCH

Ubiquitylation of CD98 limits cell proliferation and clonal expansion

(2015) J. N. G. Ablack et al.   JOURNAL OF CELL SCIENCE

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Specific Depletion of Ly6Chi Inflammatory Monocytes Prevents Immunopathology in Experimental Cerebral Malaria

(2015) Beatrix Schumak et al.   PLoS One

ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice

(2015) R. Stöhr et al.   Scientific Reports

Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells

(2015) Ting Liu et al.   Scientific Reports

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Ubiquitin ligase Cbl-b and obesity-induced insulin resistance [Review]

(2014) Tomoki Abe et al.   ENDOCRINE JOURNAL

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

(2013) A. P. Hutchins et al.   Briefings in Functional Genomics

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

(2013) Tuo Deng et al.   Cell Metabolism

Ubiquitination of HLA-DO by MARCH family E3 ligases

(2013) Martin Jahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals

(2013) Minou Adib-Conquy et al.   IMMUNOLOGY AND CELL BIOLOGY

Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells

(2013) Rikiya Ishikawa et al.   INTERNATIONAL IMMUNOLOGY

Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Receptor 1

(2013) Bert van de Kooij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

(2013) Jaehak Oh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Origin of monocytes and macrophages in a committed progenitor

(2013) Jan Hettinger et al.   NATURE IMMUNOLOGY

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

(2013) K. D. Nguyen et al.   SCIENCE

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Ubiquitination of Human Leukocyte Antigen (HLA)-DM by Different Membrane-associated RING-CH (MARCH) Protein Family E3 Ligases Targets Different Endocytic Pathways

(2012) Martin Jahnke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Francisella tularensis Elicits IL-10 via a PGE2-Inducible Factor, to Drive Macrophage MARCH1 Expression and Class II Down-Regulation

(2012) Danielle Hunt et al.   PLoS One

The E3 ubiquitin ligase MARCH8 negatively regulates IL-1 -induced NF- B activation by targeting the IL1RAP coreceptor for ubiquitination and degradation

(2012) R. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

TLR-induced activation of Btk – Role for endosomal MHC class II molecules revealed

(2011) Joan Ní Gabhann et al.   CELL RESEARCH

Ubiquitin-mediated Regulation of CD86 Protein Expression by the Ubiquitin Ligase Membrane-associated RING-CH-1 (MARCH1)

(2011) Kathleen Corcoran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

(2011) Mingjin Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

(2011) Lina E. Tze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells

(2011) G. Baravalle et al.   JOURNAL OF IMMUNOLOGY

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

(2011) Xingguang Liu et al.   NATURE IMMUNOLOGY

Monocyte trafficking in acute and chronic inflammation

(2011) Molly A. Ingersoll et al.   TRENDS IN IMMUNOLOGY

Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas

(2010) Cheolho Cheong et al.   CELL

Monocytes in atherosclerosis: subsets and functions

(2010) Kevin J. Woollard et al.   Nature Reviews Cardiology

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

MHC Class II Molecules Enhance Toll-Like Receptor Mediated Innate Immune Responses

(2010) Remo Frei et al.   PLoS One

Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells

(2010) E. Walseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation

(2009) Pui Y. Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Cutting Edge: Requirement of MARCH-I-Mediated MHC II Ubiquitination for the Maintenance of Conventional Dendritic Cells

(2009) M. Ohmura-Hoshino et al.   JOURNAL OF IMMUNOLOGY

Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches

(2008) Subhankar Paul   BIOESSAYS

Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes

(2008) Jacques Thibodeau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Major Histocompatibility Complex Class II-Peptide Complexes Internalize Using a Clathrin- and Dynamin-independent Endocytosis Pathway

(2008) Even Walseng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

(2008) A. De Gassart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRANULOCYTE-MACROPHAGE-COLONY-STIMULATING FACTOR-DEPENDENT PERITONEAL MACROPHAGE RESPONSES DETERMINE SURVIVAL IN EXPERIMENTALLY INDUCED PERITONITIS AND SEPSIS IN MICE

(2008) Donn Spight et al.   SHOCK