Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

(2018) Yann Cormerais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erratum: Cancer metabolism: a therapeutic perspective

(2017) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

(2017) Ann Lin et al.   eLife

Aryl hydrocarbon receptor (AHR) regulation of L-Type Amino Acid Transporter 1 (LAT-1) expression in MCF-7 and MDA-MB-231 breast cancer cells

(2016) Justin K. Tomblin et al.   BIOCHEMICAL PHARMACOLOGY

ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis

(2016) Haiquan Lu et al.   CANCER LETTERS

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

(2016) Y. Cormerais et al.   CANCER RESEARCH

Efficacy of systemlamino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma

(2016) Yasuhiro Ohshima et al.   CANCER SCIENCE

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma

(2016) Amy D. Marshall et al.   INTERNATIONAL JOURNAL OF CANCER

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

(2016) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment

(2015) I. L. Romero et al.   CLINICAL CANCER RESEARCH

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge

(2015) Katarzyna Tomczak et al.   Wspolczesna Onkologia-Contemporary Oncology

Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration

(2014) Keatdamrong Janpipatkul et al.   CELLULAR SIGNALLING

Targeting glutamine transport to suppress melanoma cell growth

(2014) Qian Wang et al.   INTERNATIONAL JOURNAL OF CANCER

The SLC38 family of sodium–amino acid co-transporters

(2013) Stefan Bröer   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Downregulation of L-type amino acid transporter 1 expression inhibits the growth, migration and invasion of gastric cancer cells

(2013) LIANGHUI SHI et al.   Oncology Letters

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells

(2012) KEITARO HAYASHI et al.   ONCOLOGY REPORTS

Therapeutic targets in cancer cell metabolism and death

(2011) I Iaccarino et al.   CELL DEATH AND DIFFERENTIATION

Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: A possible target for combination therapy with anti-proliferative aminopeptidase inhibitors

(2010) Xuetao Fan et al.   BIOCHEMICAL PHARMACOLOGY

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Rational Design Leads to More Potent RNA Interference Against Hepatitis B Virus: Factors Effecting Silencing Efficiency

(2008) Kathy Keck et al.   MOLECULAR THERAPY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA