Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-08-03
DOI
10.3389/fonc.2018.00237
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CD38-NAD + Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
- (2018) Shilpak Chatterjee et al. Cell Metabolism
- Myeloid-derived suppressor cells coming of age
- (2018) Filippo Veglia et al. NATURE IMMUNOLOGY
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- (2018) Evanna L. Mills et al. NATURE
- Fire and water: Tumor cell adaptation to metabolic conditions
- (2017) Rob A. Cairns et al. EXPERIMENTAL CELL RESEARCH
- Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology
- (2017) Antonio Sica et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling
- (2017) Kai Yang et al. NATURE
- Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
- (2017) Kenji Chamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
- (2017) Lindsay Wilde et al. SEMINARS IN ONCOLOGY
- Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis
- (2017) Shiou-Ling Jian et al. Cell Death & Disease
- PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity
- (2017) Maria Gato-Cañas et al. Cell Reports
- Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
- (2017) Petros A. Tyrakis et al. Cell Reports
- Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses
- (2017) Nikolaos Patsoukis et al. Frontiers in Immunology
- Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells
- (2017) Amir A. Al-Khami et al. OncoImmunology
- Coinhibitory Pathways in Immunotherapy for Cancer
- (2016) Susanne H. Baumeister et al. Annual Review of Immunology
- Glutamine transporters in mammalian cells and their functions in physiology and cancer
- (2016) Yangzom D. Bhutia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma
- (2016) Curtis A. Clark et al. CANCER RESEARCH
- Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy
- (2016) Madhusudhanan Sukumar et al. Cell Metabolism
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
- (2016) Hu Zeng et al. IMMUNITY
- The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses
- (2016) Lindsay K. Ward-Kavanagh et al. IMMUNITY
- Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
- (2016) Ana C. Anderson et al. IMMUNITY
- Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
- (2016) Frank A. Schildberg et al. IMMUNITY
- Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation
- (2016) Stanley Ching-Cheng Huang et al. IMMUNITY
- Atorvastatin promotes the expansion of myeloid-derived suppressor cells and attenuates murine colitis
- (2016) Aihua Lei et al. IMMUNOLOGY
- The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia
- (2016) M Qorraj et al. LEUKEMIA
- Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
- (2016) Mahima Swamy et al. NATURE IMMUNOLOGY
- Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
- (2016) Vassiliki A. Boussiotis NEW ENGLAND JOURNAL OF MEDICINE
- IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
- (2016) David H. Munn et al. TRENDS IN IMMUNOLOGY
- Attenuation of the programmed cell death-1 pathway increases the M1 polarization of macrophages induced by zymosan
- (2016) W Chen et al. Cell Death & Disease
- Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
- (2016) Vincenzo Bronte et al. Nature Communications
- On the origin of myeloid-derived suppressor cells
- (2016) Camilla Rydberg Millrud et al. Oncotarget
- Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer
- (2016) Cecilia Marini et al. Scientific Reports
- Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
- (2016) Anthony J Covarrubias et al. eLife
- Hypoxia and metabolic adaptation of cancer cells
- (2016) K L Eales et al. Oncogenesis
- Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination
- (2016) Anke Redeker et al. Frontiers in Immunology
- Drug-induced mitochondrial dysfunction and cardiotoxicity
- (2015) Zoltán V Varga et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs
- (2015) Y. D. Bhutia et al. CANCER RESEARCH
- Tumors and Mitochondrial Respiration: A Neglected Connection
- (2015) Andrea Viale et al. CANCER RESEARCH
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth
- (2015) Sonja Kleffel et al. CELL
- Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
- (2015) Autumn G. York et al. CELL
- The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
- (2015) Julianna Blagih et al. IMMUNITY
- Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
- (2015) Abhishek K. Jha et al. IMMUNITY
- Metabolic Reprogramming of Immune Cells in Cancer Progression
- (2015) Subhra K. Biswas IMMUNITY
- Mitochondria in the Regulation of Innate and Adaptive Immunity
- (2015) Samuel E. Weinberg et al. IMMUNITY
- Immunometabolism governs dendritic cell and macrophage function
- (2015) Luke A.J. O’Neill et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NF-κB Regulates PD-1 Expression in Macrophages
- (2015) Alexander P. R. Bally et al. JOURNAL OF IMMUNOLOGY
- 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- (2015) Adrienne H Long et al. NATURE MEDICINE
- Immune-mediated antitumor effect by type 2 diabetes drug, metformin
- (2015) Shingo Eikawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
- (2015) David L. Porter et al. Science Translational Medicine
- Fatty acid metabolism in the regulation of T cell function
- (2015) Matthias Lochner et al. TRENDS IN IMMUNOLOGY
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies
- (2015) F. Hossain et al. Cancer Immunology Research
- Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition
- (2015) Rebecca Lamb et al. Oncotarget
- Adoptive Immunotherapy for Cancer or Viruses
- (2014) Marcela V. Maus et al. Annual Review of Immunology
- Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR)
- (2014) Jisun Kim et al. BMC CANCER
- Cardiac NO signalling in the metabolic syndrome
- (2014) O Pechánová et al. BRITISH JOURNAL OF PHARMACOLOGY
- Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans
- (2014) Smita S. Chandran et al. CLINICAL CANCER RESEARCH
- Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
- (2014) Y.-C. Lu et al. CLINICAL CANCER RESEARCH
- Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
- (2014) Mako Nakaya et al. IMMUNITY
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
- (2014) Muhammad Zaeem Noman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ERK-Dependent Bim Modulation Downstream of the 4-1BB-TRAF1 Signaling Axis Is a Critical Mediator of CD8 T Cell Survival In Vivo
- (2014) L. Sabbagh et al. JOURNAL OF IMMUNOLOGY
- De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
- (2014) Luciana Berod et al. NATURE MEDICINE
- Statins: From cholesterol-lowering drugs to novel immunomodulators for the treatment of Th17-mediated autoimmune diseases
- (2014) Cristina Ulivieri et al. PHARMACOLOGICAL RESEARCH
- Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer
- (2014) E. Tran et al. SCIENCE
- Metabolic control of dendritic cell activation and function: recent advances and clinical implications
- (2014) Frontiers in Immunology
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
- (2013) J. R. Doherty et al. CANCER RESEARCH
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
- (2013) Cecilia Marini et al. CELL CYCLE
- Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
- (2013) R. Polanski et al. CLINICAL CANCER RESEARCH
- Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
- (2013) Laura A. Sena et al. IMMUNITY
- Design and development of therapies using chimeric antigen receptor-expressing T cells
- (2013) Gianpietro Dotti et al. IMMUNOLOGICAL REVIEWS
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Glutamine and cancer: cell biology, physiology, and clinical opportunities
- (2013) Christopher T. Hensley et al. JOURNAL OF CLINICAL INVESTIGATION
- T Cell Costimulation with Anti-CD137 Monoclonal Antibodies Is Mediated by K63-Polyubiquitin-Dependent Signals from Endosomes
- (2013) I. Martinez-Forero et al. JOURNAL OF IMMUNOLOGY
- The SLC16 gene family – Structure, role and regulation in health and disease
- (2013) Andrew P. Halestrap MOLECULAR ASPECTS OF MEDICINE
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Fueling Immunity: Insights into Metabolism and Lymphocyte Function
- (2013) E. L. Pearce et al. SCIENCE
- The Basic Principles of Chimeric Antigen Receptor Design
- (2013) Michel Sadelain et al. Cancer Discovery
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Orchestration of Metabolism by Macrophages
- (2012) Subhra K. Biswas et al. Cell Metabolism
- T cell Activation Is Driven by an ADP-Dependent Glucokinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
- (2012) Marcin M. Kamiński et al. Cell Reports
- Alternative Macrophage Activation and Metabolism
- (2011) Justin I. Odegaard et al. Annual Review of Pathology-Mechanisms of Disease
- Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
- (2011) R. J. Brentjens et al. BLOOD
- Modulation of human T-cell functions by reactive nitrogen species
- (2011) Tihana Kasic et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature
- (2011) Pawel Muranski et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- Tumor-Infiltrating Programmed Death Receptor-1+ Dendritic Cells Mediate Immune Suppression in Ovarian Cancer
- (2011) J. Krempski et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
- (2011) Greg M Delgoffe et al. NATURE IMMUNOLOGY
- Immune parameters affecting the efficacy of chemotherapeutic regimens
- (2011) Laurence Zitvogel et al. Nature Reviews Clinical Oncology
- Uncoupling of ATP-depletion and cell death in human dopaminergic neurons
- (2011) Dominik Pöltl et al. NEUROTOXICOLOGY
- CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
- (2011) R. Le Floch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of mTOR in memory CD8+ T-cell differentiation
- (2010) Koichi Araki et al. IMMUNOLOGICAL REVIEWS
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
- (2010) Subhra K Biswas et al. NATURE IMMUNOLOGY
- Lipid accumulation and dendritic cell dysfunction in cancer
- (2010) Donna L Herber et al. NATURE MEDICINE
- Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling
- (2010) Aimee J. Marko et al. PLoS One
- Glutamine addiction: a new therapeutic target in cancer
- (2010) David R. Wise et al. TRENDS IN BIOCHEMICAL SCIENCES
- Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine
- (2009) M. K. Srivastava et al. CANCER RESEARCH
- HIF-1: upstream and downstream of cancer metabolism
- (2009) Gregg L Semenza CURRENT OPINION IN GENETICS & DEVELOPMENT
- PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
- (2009) Loise M. Francisco et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
- (2009) R J DeBerardinis et al. ONCOGENE
- ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
- (2009) K. E. Wellen et al. SCIENCE
- B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
- (2008) T. Azuma et al. BLOOD
- Tumor-specific Th17-polarized cells eradicate large established melanoma
- (2008) P. Muranski et al. BLOOD
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Brick by brick: metabolism and tumor cell growth
- (2008) Ralph J DeBerardinis et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Advances in measuring cellular bioenergetics using extracellular flux
- (2008) David A. Ferrick et al. DRUG DISCOVERY TODAY
- Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation
- (2008) Cristina Ulivieri et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α
- (2008) Jeremy Ben-Shoshan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CTLA-4 Control over Foxp3+ Regulatory T Cell Function
- (2008) K. Wing et al. SCIENCE
- Macrophage polarization in tumour progression
- (2008) Antonio Sica et al. SEMINARS IN CANCER BIOLOGY
- Pleiotropic effects of statin therapy: molecular mechanisms and clinical results
- (2008) Chao-Yung Wang et al. TRENDS IN MOLECULAR MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search