A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis

Annual Report to the Nation on the Status of Cancer, 1975-2012, featuring the increasing incidence of liver cancer

(2016) A. Blythe Ryerson et al.   CANCER

Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors

(2016) T. R. Kress et al.   CANCER RESEARCH

Monocytes promote liver carcinogenesis in an oncogene-specific manner

(2016) Vladislava Juric et al.   JOURNAL OF HEPATOLOGY

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

(2016) Lei Li et al.   JOURNAL OF HEPATOLOGY

Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade

(2016) Chunmei Wang et al.   LIVER INTERNATIONAL

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

(2016) Junjie Hu et al.   Scientific Reports

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Genetic Landscape and Biomarkers of Hepatocellular Carcinoma

(2015) Jessica Zucman-Rossi et al.   GASTROENTEROLOGY

Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer

(2015) Mohamed Hassanein et al.   INTERNATIONAL JOURNAL OF CANCER

Advances in targeted therapies for hepatocellular carcinoma in the genomic era

(2015) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

SLC transporters as therapeutic targets: emerging opportunities

(2015) Lawrence Lin et al.   NATURE REVIEWS DRUG DISCOVERY

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice

(2014) Chunmei Wang et al.   HEPATOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib

(2014) Andrew X. Zhu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Long Non-Coding RNA GAS5 Cooperates with the Eukaryotic Translation Initiation Factor 4E to Regulate c-Myc Translation

(2014) Guangzhen Hu et al.   PLoS One

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends

(2013) Matthias S. Matter et al.   JOURNAL OF HEPATOLOGY

Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development

(2013) Qian Wang et al.   JNCI-Journal of the National Cancer Institute

Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma

(2013) Martha M. Kirstein et al.   LIVER INTERNATIONAL

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

(2013) M. Pourdehnad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrient transporters: the Achilles’ heel of anabolism

(2013) Alison N. McCracken et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells

(2012) Edward Kai-Hua Chow et al.   HEPATOLOGY

MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma Are Regulated by HMG-CoA Reductase

(2011) Z. Cao et al.   CANCER RESEARCH

Growth controls connect: Interactions between c-myc and the tuberous sclerosis complex-mTOR pathway

(2011) Emmett V. Schmidt et al.   CELL CYCLE

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

(2008) C.-J. Lin et al.   CANCER RESEARCH

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

(2008) Augusto Villanueva et al.   GASTROENTEROLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA