ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma

(2019) Jason C. Fleming et al.   BRITISH JOURNAL OF CANCER

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

The role of ASCT2 in cancer: A review

(2018) Yang Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of SLC1A5 sensitizes colorectal cancer to cetuximab

(2018) Huanrong Ma et al.   INTERNATIONAL JOURNAL OF CANCER

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

(2018) Yann Cormerais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth

(2018) Jianxin Ye et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

(2018) Angelika Bröer et al.   Frontiers in Pharmacology

Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase

(2017) Pachiyappan Kamarajan et al.   JOURNAL OF PROTEOME RESEARCH

Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism

(2017) J Dong et al.   Oncogenesis

ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis

(2016) Haiquan Lu et al.   CANCER LETTERS

Chemotherapy in locally advanced head and neck squamous cell carcinoma

(2016) Bishal Gyawali et al.   CANCER TREATMENT REVIEWS

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

(2016) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of autophagy in squamous cell carcinoma of the head and neck

(2016) Benjamin Cosway et al.   ORAL ONCOLOGY

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Glutaminolysis and autophagy in cancer

(2015) Victor H Villar et al.   Autophagy

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Current Treatment Options for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

(2015) Assuntina G. Sacco et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma

(2015) L Zhang et al.   Cell Death & Disease

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Prognostic significance of amino-acid transporter expression (LAT1, ASCT2 and xCT) in surgically resected tongue cancer

(2014) M Toyoda et al.   BRITISH JOURNAL OF CANCER

Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy

(2013) AN-CHENG HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

(2012) M. Hassanein et al.   CLINICAL CANCER RESEARCH

Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells

(2011) Vlad C. Sandulache et al.   CANCER

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck

(2010) Scott M. Langevin et al.   CANCER

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE