Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-07-19
DOI
10.3389/fphar.2018.00785
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
- (2018) Yann Cormerais et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core
- (2018) Lukas Zimmermann et al. JOURNAL OF MOLECULAR BIOLOGY
- Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
- (2018) Michael L Schulte et al. NATURE MEDICINE
- SWISS-MODEL: homology modelling of protein structures and complexes
- (2018) Andrew Waterhouse et al. NUCLEIC ACIDS RESEARCH
- Amino Acid Transporters as Disease Modifiers and Drug Targets
- (2018) Stefan Bröer SLAS Discovery
- Heteromeric amino acid transporters. In search of the molecular bases of transport cycle mechanisms
- (2016) M. Palacin et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport
- (2016) Michael L. Schulte et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
- (2016) Y. Cormerais et al. CANCER RESEARCH
- Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
- (2016) Aaron M. Hosios et al. DEVELOPMENTAL CELL
- Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells
- (2016) Angelika Bröer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC
- (2016) Hüseyin Ilgü et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs
- (2015) Y. D. Bhutia et al. CANCER RESEARCH
- LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter
- (2015) Lara Napolitano et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer
- (2015) Mohamed Hassanein et al. INTERNATIONAL JOURNAL OF CANCER
- Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
- (2015) Qian Wang et al. JOURNAL OF PATHOLOGY
- ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
- (2015) M van Geldermalsen et al. ONCOGENE
- ATF4 and N-Myc coordinate glutamine metabolism inMYCN-amplified neuroblastoma cells through ASCT2 activation
- (2014) Ping Ren et al. JOURNAL OF PATHOLOGY
- Asparagine synthetase: regulation by cell stress and involvement in tumor biology
- (2013) Mukundh N. Balasubramanian et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris — functional and kinetic asymmetry revealed in proteoliposomes
- (2013) Piero Pingitore et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The SLC38 family of sodium–amino acid co-transporters
- (2013) Stefan Bröer PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival
- (2012) M. Hassanein et al. CLINICAL CANCER RESEARCH
- Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound
- (2011) Michael F. Wempe et al. Drug Metabolism and Pharmacokinetics
- Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
- (2009) Paul Nicklin et al. CELL
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now