CD38 in the Age of Covid-19: a Medical Perspective.

Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses

(2021) Young Min Son et al.   Science Immunology

Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1

(2020) Heather S. Loring et al.   BIOCHEMISTRY

Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients

(2020) Randy S. Wax et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Recent discovery and development of inhibitors targeting coronaviruses

(2020) Thanigaimalai Pillaiyar et al.   DRUG DISCOVERY TODAY

The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions

(2020) Anthony R. Fehr et al.   GENES & DEVELOPMENT

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Novel coronavirus infection and pregnancy

(2020) H. Yang et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

(2020) Eri Katsuyama et al.   Cell Reports

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Host Calcium Channels and Pumps in Viral Infections

(2020) Xingjuan Chen et al.   Cells

Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19

(2020) Luca Steardo et al.   Acta Physiologica

COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

(2020) Camillo Sargiacomo et al.   Aging-US

Modulation of aryl hydrocarbon receptor (AHR) and the NAD+-consuming enzyme CD38: Searches of therapeutic options for nonalcoholic fatty liver disease (NAFLD)

(2020) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

A hypothesis for pathobiology and treatment of COVID‐19 : The centrality of ACE1 / ACE2 imbalance

(2020) Krishna Sriram et al.   BRITISH JOURNAL OF PHARMACOLOGY

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Risks of ACE Inhibitor and ARB Usage in COVID‐19: Evaluating the Evidence

(2020) Krishna Sriram et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Compromised DNA repair is responsible for diabetes‐associated fibrosis

(2020) Varun Kumar et al.   EMBO JOURNAL

Cellular NAD + , fibroblast senescence and pulmonary fibrosis

(2020) Tianju Liu et al.   FASEB JOURNAL

Respiratory virus infections: Understanding COVID-19

(2020) Kanta Subbarao et al.   IMMUNITY

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

The many faces of the anti-COVID immune response

(2020) Santosha A. Vardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs

(2020) Abhigyan Choudhury et al.   JOURNAL OF MEDICAL VIROLOGY

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

(2020) Katherine R. Balka et al.   Cell Reports

Coronavirus Disease (Covid-19): What Are We Learning in a Country With High Mortality Rate?

(2020) Luciano Mutti et al.   Frontiers in Immunology

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

(2020) Xiaoyan Liu et al.   Acta Pharmaceutica Sinica B

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

(2020) Yosra A. Helmy et al.   Journal of Clinical Medicine

COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches

(2020) F. Moccia et al.   GeroScience

Molecular immune pathogenesis and diagnosis of COVID-19

(2020) Xiaowei Li et al.   Journal of Pharmaceutical Analysis

H2S as a potential defense against COVID-19?

(2020) Guangdong Yang   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection

(2020) Meng‐Wei Zhuang et al.   JOURNAL OF MEDICAL VIROLOGY

Coronavirus breakthrough: dexamethasone is first drug shown to save lives

(2020) Heidi Ledford   NATURE

IMMUNOMETABOLIC STATUS OF COVID-19 CANCER PATIENTS

(2020) Antonio Sica et al.   PHYSIOLOGICAL REVIEWS

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

(2020) Hong-Long Ji et al.   PHYSIOLOGICAL REVIEWS

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

(2020) Petra Krafcikova et al.   Nature Communications

Modulators of Oxidative Stress: Chemical and Pharmacological Aspects

(2020) Luciano Saso et al.   Antioxidants

Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site

(2020) Javier A. Jaimes et al.   iScience

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide?

(2020) Abdulla A-B Badawy   BIOSCIENCE REPORTS

Renin angiotensin system at the interface of COVID-19 infection

(2020) Rukhsana Gul et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Circular Life of Human CD38: From Basic Science to Clinics and Back

(2020) Alberto L. Horenstein et al.   MOLECULES

Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus

(2020) Lennard Ostendorf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pregnancy and COVID-19

(2020) Elizabeth AN Wastnedge et al.   PHYSIOLOGICAL REVIEWS

Therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia

(2020) Pierpaolo Correale et al.   PLoS One

Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium

(2020) Satria P. Sajuthi et al.   Nature Communications

Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?

(2020) Carmela Falcone et al.   Journal of Clinical Medicine

Monoclonal Antibody Therapies in Systemic Light-Chain Amyloidosis

(2020) Amandeep Godara et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD+ Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

(2020) Natalie Baum et al.   Cancers

Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis

(2020) Bo Shi et al.   iScience

Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets

(2020) Krishna Sriram et al.   PHYSIOLOGICAL REVIEWS

Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade

(2019) Widad Dantoft et al.   Frontiers in Microbiology

NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

(2019) Chunjing Bian et al.   Nature Communications

Oxytocin pathway gene networks in the human brain

(2019) Daniel S. Quintana et al.   Nature Communications

Immunotherapy in Multiple Myeloma: Accelerating on the Path to the Patient

(2019) Irene Ghobrial et al.   Clinical Lymphoma Myeloma & Leukemia

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

(2019) Claudia Chini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rational Design and Identification of Small‐Molecule Allosteric Inhibitors of CD38.

(2019) Liangren Zhang et al.   CHEMBIOCHEM

Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia

(2019) Alak Manna et al.   CLINICAL CANCER RESEARCH

NAD metabolites interfere with proliferation and functional properties of THP-1 cells

(2019) Katharina Petin et al.   Innate Immunity

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment

(2019) Tamas Kiss et al.   GeroScience

CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy

(2019) Alberto L. Horenstein et al.   Frontiers in Immunology

The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases

(2019) Kelly A. Hogan et al.   Frontiers in Immunology

L-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis

(2019) Kamel S. Kamel et al.   KIDNEY INTERNATIONAL

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

(2019) Yasir S. Elhassan et al.   Cell Reports

Resolving the topological enigma in Ca2+-signaling by cyclic ADP-ribose and NAADP

(2019) Hon Cheung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide

(2019) Seon Beom Song et al.   Metabolomics

ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1

(2019) Kenneth I. Onyedibe et al.   MOLECULES

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD + Decline

(2018) Mariana G. Tarragó et al.   Cell Metabolism

CD38-NAD + Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

(2018) Shilpak Chatterjee et al.   Cell Metabolism

Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression

(2018) Bingyan Shu et al.   CELLULAR SIGNALLING

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Canonical and non-canonical adenosinergic pathways

(2018) E. Ferretti et al.   IMMUNOLOGY LETTERS

Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)-dependent calcium signalling

(2018) Andreas H. Guse et al.   JOURNAL OF PHYSIOLOGY-LONDON

Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis

(2018) Thomas J. Bell et al.   MATRIX BIOLOGY

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

(2018) Eduardo N. Chini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cytokine-Induced Killer Cells Express CD39, CD38, CD203a, CD73 Ectoenzymes and P1 Adenosinergic Receptors

(2018) Alberto L. Horenstein et al.   Frontiers in Pharmacology

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances

(2018) Anna Ohradanova-Repic et al.   Frontiers in Immunology

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions

(2018) Stephanie A. Amici et al.   Frontiers in Immunology

Quantitation of NAD+: Why do we need to measure it?

(2018) Yue Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system

(2018) Gihan S. Gunaratne et al.   CELL CALCIUM

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

(2018) Kazuki Kato et al.   Nature Communications

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

(2018) Gabor A. Fulop et al.   GeroScience

CD38 modulates respiratory syncytial virus-driven proinflammatory processes in human monocyte-derived dendritic cells

(2017) Ilaria Schiavoni et al.   IMMUNOLOGY

New Concepts and Mechanisms of Platelet Activation Signaling

(2017) Brian Estevez et al.   PHYSIOLOGY

Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels

(2017) Jun Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

(2017) Jonathan Matalonga et al.   Cell Reports

Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?

(2016) Alejandro Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Reduction in C-reactive protein indicates successful targeting of the IL-1/IL-6 axis resulting in improved survival in early stage multiple myeloma

(2016) John A. Lust et al.   AMERICAN JOURNAL OF HEMATOLOGY

NAD+: The convergence of DNA repair and mitophagy

(2016) Evandro F. Fang et al.   Autophagy

Why NAD + Declines during Aging: It’s Destroyed

(2016) Michael B. Schultz et al.   Cell Metabolism

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates With Progression of Human Myeloma

(2016) Alberto L Horenstein et al.   MOLECULAR MEDICINE

Cyanidin-3- O -glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation

(2016) Daniela Ferrari et al.   TOXICOLOGY LETTERS

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

(2016) Anthony R. Fehr et al.   mBio

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

CD38 Mediates Angiotensin II–Induced Intracellular Ca2+Release in Rat Pulmonary Arterial Smooth Muscle Cells

(2015) Suengwon Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release

(2015) Julia V. Gerasimenko et al.   CELL CALCIUM

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

(2015) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD56brightCD16−NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+T Cell Proliferation

(2015) Fabio Morandi et al.   JOURNAL OF IMMUNOLOGY

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

(2015) Curt D. Haffner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived PeptideIn VitroandIn VivoTo Reduce Replication and Pathogenesis

(2015) Yi Wang et al.   JOURNAL OF VIROLOGY

The Redox-sensitive Induction of the Local Angiotensin System Promotes Both Premature and Replicative Endothelial Senescence: Preventive Effect of a StandardizedCrataegusExtract

(2015) Sonia Khemais-Benkhiat et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ferret models of viral pathogenesis

(2015) T. Enkirch et al.   VIROLOGY

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

NAD+-Metabolizing Ectoenzymes in Remodeling Tumor–Host Interactions: The Human Myeloma Model

(2015) Alberto Horenstein et al.   Cells

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans

(2013) G. T. Gorgun et al.   BLOOD

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress

(2013) Nicola E. Clarke et al.   CLINICAL SCIENCE

Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

(2013) S. Vedantham et al.   DIABETES

CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγCytokines and Proliferation

(2013) Giorgio Fedele et al.   MEDIATORS OF INFLAMMATION

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes

(2013) Alberto L Horenstein et al.   OncoImmunology

Roles of cADPR and NAADP in pancreatic cells

(2012) Y. Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease

(2012) Dinesh Shrikrishna et al.   CLINICAL SCIENCE

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization

(2012) Hon Cheung Lee   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase

(2012) S. L. Grady et al.   JOURNAL OF VIROLOGY

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAADP Mediates Insulin-Stimulated Glucose Uptake and Insulin Sensitization by PPARγ in Adipocytes

(2012) Eun-Kyung Song et al.   Cell Reports

The high-resolution crystal structure of periplasmicHaemophilus influenzaeNAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism

(2011) Silvia Garavaglia et al.   BIOCHEMICAL JOURNAL

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

(2011) S. Serra et al.   BLOOD

Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis

(2011) Shin-ichiro Imai   FEBS LETTERS

Critical Role for CD38-mediated Ca2+Signaling in Thrombin-induced Procoagulant Activity of Mouse Platelets and Hemostasis

(2011) Mazhar Mushtaq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

Egr-1—A Ca2+-regulated transcription factor

(2010) Gerald Thiel et al.   CELL CALCIUM

Impact of changes in antigen level on CD38/PD-1 co-expression on HIV-specific CD8 T cells in chronic, untreated HIV-1 infection

(2010) Thomas Vollbrecht et al.   JOURNAL OF MEDICAL VIROLOGY

The hidden life of NAD+-consuming ectoenzymes in the endocrine system

(2010) Fabio Malavasi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

TRPM2: a multifunctional ion channel for calcium signalling

(2010) Adriana Sumoza-Toledo et al.   JOURNAL OF PHYSIOLOGY-LONDON

CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions

(2009) Eduardo Chini   CURRENT PHARMACEUTICAL DESIGN

CD38-mediated Ca2+Signaling Contributes to Angiotensin II-induced Activation of Hepatic Stellate Cells

(2009) Seon-Young Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase

(2009) Qun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

(2009) Antony Galione et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

(2009) Yiu-Wing Kam et al.   PLoS One

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in   Cells

(2009) I. Lange et al.   Science Signaling

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse

(2008) P. Munoz et al.   BLOOD

Exercise Testing in Severe Emphysema: Association with Quality of Life and Lung Function

(2008) Cynthia D. Brown et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases

(2008) Friedrich Koch-Nolte   Frontiers in Bioscience-Landmark

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS