NAD+-Metabolizing Ectoenzymes in Remodeling Tumor–Host Interactions: The Human Myeloma Model

Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo

(2015) Ali Roghanian et al.   CANCER CELL

CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer

(2015) T. A. Karakasheva et al.   CANCER RESEARCH

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

(2015) David J. DiLillo et al.   CELL

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

CD56brightCD16−NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+T Cell Proliferation

(2015) Fabio Morandi et al.   JOURNAL OF IMMUNOLOGY

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

(2015) Fabio Morandi et al.   Oncotarget

Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation

(2015) Bonnie K. Arendt et al.   Oncotarget

Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche

(2014) Valeria Quarona et al.   Annals of the New York Academy of Sciences

A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157

(2014) Frank Preugschat et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities

(2014) Gennady G. Yegutkin   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

CD38 and bone marrow microenvironment

(2014) Antonella Chillemi   Frontiers in Bioscience-Landmark

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

(2014) Stephen M. Hatfield et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Intracellular NAD+ depletion enhances bortezomib-induced anti-myeloma activity

(2013) A. Cagnetta et al.   BLOOD

Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection

(2013) Yuling Chi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

(2013) Ubaldina Galli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer

(2013) Michail Sitkovsky et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

(2013) P Storti et al.   LEUKEMIA

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(2013) Antonella Chillemi et al.   MOLECULAR MEDICINE

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes

(2013) Alberto L Horenstein et al.   OncoImmunology

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations

(2012) Y. J. Zhao et al.   Science Signaling

CD38 and chronic lymphocytic leukemia: a decade later

(2011) F. Malavasi et al.   BLOOD

NAMPT in Regulated NAD Biosynthesis and its Pivotal Role in Human Metabolism

(2011) E S. Burgos   CURRENT MEDICINAL CHEMISTRY

Reciprocal Potentiation of the Antitumoral Activities of FK866, an Inhibitor of Nicotinamide Phosphoribosyltransferase, and Etoposide or Cisplatin in Neuroblastoma Cells

(2011) C. Travelli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sirtuin chemical mechanisms

(2010) Anthony A. Sauve   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn

(2010) Esther Zumaquero et al.   EXPERIMENTAL CELL RESEARCH

Review: NAD + : A modulator of immune functions

(2010) Andreas Grahnert et al.   Innate Immunity

Extracellular NAD+shapes the Foxp3+regulatory T cell compartment through the ART2–P2X7 pathway

(2010) Sandra Hubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The hidden life of NAD+-consuming ectoenzymes in the endocrine system

(2010) Fabio Malavasi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

(2007) Paul et al.   Frontiers in Bioscience-Landmark