Protein arginine methylation: from enigmatic functions to therapeutic targeting
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Protein arginine methylation: from enigmatic functions to therapeutic targeting
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-03-20
DOI
10.1038/s41573-021-00159-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
- (2021) Peter Kalev et al. CANCER CELL
- Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
- (2021) Elizabeth A. Bowling et al. CELL
- PRMT5 inhibition disrupts splicing and stemness in glioblastoma
- (2021) Patty Sachamitr et al. Nature Communications
- PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN
- (2020) Friederike Pastore et al. BLOOD
- Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
- (2020) Patrick J. Metz et al. Cell Reports
- PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
- (2020) Daniele Musiani et al. Cell Reports
- Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor
- (2020) Yudao Shen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protein Arginine N-methyltransferases 5 and 7 Promote HIV-1 Production
- (2020) Hironobu Murakami et al. Viruses-Basel
- Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
- (2020) Magdalena M. Szewczyk et al. Nature Communications
- Methylation of HSP70 orchestrates its binding to and stabilization of BCL-2 mRNA and renders pancreatic cancer cells resistant to therapeutics
- (2020) Liang Wang et al. CANCER RESEARCH
- Modulating the modulators: regulation of protein arginine methyltransferases by post-translational modifications
- (2020) Antja-Voy Hartley et al. DRUG DISCOVERY TODAY
- Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code
- (2020) Nitika et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Post-translational modifications of Hsp90 and translating the chaperone code
- (2020) Sarah J. Backe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of First-in-class Protein Arginine Methyltransferase 5 (PRMT5) Degraders
- (2020) Yudao Shen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)
- (2020) Rachel L. Palte et al. ACS Medicinal Chemistry Letters
- PRMT5 regulates T cell interferon response and is a target for acute graft-versus-host disease
- (2020) Katiri J. Snyder et al. JCI Insight
- A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode
- (2020) Vineet Pande et al. ACS Medicinal Chemistry Letters
- Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling
- (2020) Yingqi Liu et al. eLife
- Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis
- (2019) Seri Choi et al. Autophagy
- The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer
- (2019) Ali Choucair et al. ONCOGENE
- PRMT1 loss sensitizes cells to PRMT5 inhibition
- (2019) Guozhen Gao et al. NUCLEIC ACIDS RESEARCH
- The expanding landscape of ‘oncohistone’ mutations in human cancers
- (2019) Benjamin A. Nacev et al. NATURE
- Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys
- (2019) Ming Wu et al. FASEB JOURNAL
- PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis
- (2019) Yi Qin et al. Cell Communication and Signaling
- Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice
- (2019) Menno Hoekstra et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Methylation of C/EBPα by PRMT1 inhibits its tumor suppressive function in breast cancer
- (2019) Li-ming Liu et al. CANCER RESEARCH
- PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K/AKT in lymphoma cells
- (2019) Fen Zhu et al. LEUKEMIA
- Proteomics profiling of arginine methylation defines PRMT5 substrate specificity
- (2019) Daniele Musiani et al. Science Signaling
- Discovery of Potent and Selective Covalent Protein Arginine Methyl-transferase 5 (PRMT5) Inhibitors.
- (2019) Hong Lin et al. ACS Medicinal Chemistry Letters
- Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers
- (2019) Mathilde Vinet et al. Cancer Medicine
- A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy
- (2019) Zhuan Zhou et al. EBioMedicine
- Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
- (2019) Andrew Fedoriw et al. CANCER CELL
- Targeting protein methylation: from chemical tools to precision medicines
- (2019) David Dilworth et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Cellular consequences of arginine methylation
- (2019) Benjamin M. Lorton et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6
- (2019) Md. Saiful Islam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The regulation, functions and clinical relevance of arginine methylation
- (2019) Ernesto Guccione et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- DNA Damage Repair in Huntington’s Disease and Other Neurodegenerative Diseases
- (2019) T. Maiuri et al. Neurotherapeutics
- PRMTs and Arginine Methylation: Cancer’s Best-Kept Secret?
- (2019) James Jarrold et al. TRENDS IN MOLECULAR MEDICINE
- Liquid–Liquid Phase Separation in Disease
- (2019) Simon Alberti et al. Annual Review of Genetics
- Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
- (2019) Jia Yi Fong et al. CANCER CELL
- Metadherin–PRMT5 complex enhances the metastasis of hepatocellular carcinoma through the WNT–β-catenin signaling pathway
- (2019) Kai Zhu et al. CARCINOGENESIS
- Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade
- (2019) Joseph L. Benci et al. CELL
- PRMT5 is necessary to form distinct cartilage identities in the knee and long bone
- (2019) Janani Ramachandran et al. DEVELOPMENTAL BIOLOGY
- Inhibition of DOT1L and PRMT5 promote synergistic anti-tumor activity in a human MLL leukemia model induced by CRISPR/Cas9
- (2019) Kathy-Ann Secker et al. ONCOGENE
- Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
- (2019) Shatha AbuHammad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648
- (2019) Zhang Min et al. Cell Death & Disease
- A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
- (2019) Changzheng Du et al. Cell Reports
- 438OMETEOR-1: A phase I study of GSK3326595, a first-in-class protein arginine methyltransferase 5 (PRMT5) inhibitor, in advanced solid tumours
- (2019) L L Siu et al. ANNALS OF ONCOLOGY
- The protein arginine methyltransferase PRMT5 confers therapeutic resistance to mTOR inhibition in glioblastoma
- (2019) Brent Holmes et al. JOURNAL OF NEURO-ONCOLOGY
- PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
- (2019) Aliaksandra Radzisheuskaya et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion
- (2019) Xiao-Chuan Cai et al. eLife
- Foxp3 Post-translational Modifications and Treg Suppressive Activity
- (2019) Guoping Deng et al. Frontiers in Immunology
- PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis
- (2019) Yilong Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chemical probes for protein arginine methyltransferases
- (2019) Alice Shi Ming Li et al. METHODS
- Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function
- (2019) Alexandre Couto e Silva et al. MOLECULAR NEUROBIOLOGY
- Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor
- (2019) Renato Ferreira de Freitas et al. MOLECULES
- The timeline of epigenetic drug discovery: from reality to dreams
- (2019) A. Ganesan et al. Clinical Epigenetics
- Comparison of EMT mediated tyrosine kinase inhibitor resistance in NSCLC
- (2018) Tsatsral Iderzorig et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo
- (2018) Joya E Nahon et al. BRITISH JOURNAL OF PHARMACOLOGY
- CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
- (2018) Sarah M. Greenblatt et al. CANCER CELL
- Protein arginine methyltransferase 5 promotes lung cancer metastasis via the epigenetic regulation of miR-99 family/FGFR3 signaling
- (2018) Pengyu Jing et al. CANCER LETTERS
- Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
- (2018) Mario Hofweber et al. CELL
- FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
- (2018) Seema Qamar et al. CELL
- Expanding the clinical and molecular spectrum of PRMT7 mutations: 3 additional patients and review
- (2018) E. Agolini et al. CLINICAL GENETICS
- Inhibition of protein arginine methyltransferase 5 enhances hepatic mitochondrial biogenesis
- (2018) Lei Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RGG/RG Motif Regions in RNA Binding and Phase Separation
- (2018) P. Andrew Chong et al. JOURNAL OF MOLECULAR BIOLOGY
- Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis
- (2018) Manuela Di Franco et al. MEDIATORS OF INFLAMMATION
- Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation
- (2018) Veronica H. Ryan et al. MOLECULAR CELL
- Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease
- (2018) Xiaohong Liu et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Protein arginine methylation: an emerging regulator of the cell cycle
- (2018) Anita E. Raposo et al. Cell Division
- LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity
- (2018) Zahid Q. Bonday et al. ACS Medicinal Chemistry Letters
- CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
- (2018) Sergey Karakashev et al. Nature Communications
- The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
- (2018) Zhe Li et al. Nature Communications
- A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
- (2018) Maneka Chitiprolu et al. Nature Communications
- TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
- (2018) Kazuhide Nakayama et al. Oncotarget
- Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing
- (2018) Sarah V. Gerhart et al. Scientific Reports
- PRMT5 promotes cell proliferation by inhibiting BTG2 expression via the ERK signaling pathway in hepatocellular carcinoma
- (2018) Hai Jiang et al. Cancer Medicine
- PRMT5 inhibition promotes osteogenic differentiation of mesenchymal stromal cells and represses basal interferon stimulated gene expression
- (2018) Satya K. Kota et al. BONE
- Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and Myelination
- (2018) Sara Calabretta et al. DEVELOPMENTAL CELL
- Protein-RNA Interactions: Structural Characteristics and Hotspot Amino Acids
- (2018) Dennis M. Krüger et al. RNA
- PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2
- (2018) Dezhi Cheng et al. OncoTargets and Therapy
- PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes
- (2018) Pierre-Jacques Hamard et al. Cell Reports
- MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism
- (2018) Tamaki Suganuma et al. Cell Reports
- CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer
- (2018) Xing-Yu Zhong et al. Cell Reports
- Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells
- (2018) Yuki Kagoya et al. JOURNAL OF AUTOIMMUNITY
- TGF-β Upregulated Mitochondria Mass through the SMAD2/3→C/EBPβ→PRMT1 Signal Pathway in Primary Human Lung Fibroblasts
- (2018) Qingzhu Sun et al. JOURNAL OF IMMUNOLOGY
- Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
- (2018) Jung-Hoon Pyun et al. Nature Communications
- PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation
- (2018) Lok Hei Chan et al. Cell Reports
- Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression
- (2018) Ming-Chuan Hsu et al. Cancers
- Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression
- (2017) Pengyu Geng et al. FASEB JOURNAL
- Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule–nucleating protein G3BP1
- (2017) Wei-Chih Tsai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects
- (2017) Jay Penney et al. JOURNAL OF NEUROSCIENCE
- Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML
- (2017) S Kaushik et al. LEUKEMIA
- Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma
- (2017) A Gullà et al. LEUKEMIA
- PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination
- (2017) Thomas L. Clarke et al. MOLECULAR CELL
- Arginine Methylation: The Coming of Age
- (2017) Roméo S. Blanc et al. MOLECULAR CELL
- Host-directed therapies for bacterial and viral infections
- (2017) Stefan H. E. Kaufmann et al. NATURE REVIEWS DRUG DISCOVERY
- The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
- (2017) Madhumitha Rengasamy et al. NUCLEIC ACIDS RESEARCH
- The PAF complex regulation of Prmt5 facilitates the progression and maintenance of MLL fusion leukemia
- (2017) J Serio et al. ONCOGENE
- The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells
- (2017) Katsuya Nakai et al. Breast Cancer
- A novel SHARPIN-PRMT5-H3R2me1 axis is essential for lung cancer cell invasion
- (2017) Tingxiong Fu et al. Oncotarget
- The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer
- (2017) Nicolas Veland et al. Cell Reports
- PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression
- (2017) Kelly Chiang et al. Cell Reports
- Protein Arginine Methyltransferase 5 Inhibition Upregulates Foxp3+ Regulatory T Cells Frequency and Function during the Ulcerative Colitis
- (2017) Yingxia Zheng et al. Frontiers in Immunology
- PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core
- (2017) Barbora Lubyova et al. PLoS One
- Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
- (2017) Allison E. Drew et al. Scientific Reports
- The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention
- (2016) Alex J. Fulcher et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation
- (2016) Yan Wang et al. CANCER RESEARCH
- Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth
- (2016) L. Liu et al. CANCER RESEARCH
- Arginine methyltransferases in normal and malignant hematopoiesis
- (2016) Sarah M. Greenblatt et al. EXPERIMENTAL HEMATOLOGY
- Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly
- (2016) Wei-Chih Tsai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia
- (2016) Yanli Jin et al. JOURNAL OF CLINICAL INVESTIGATION
- Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6
- (2016) Yudao Shen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate
- (2016) Roméo Sébastien Blanc et al. MOLECULAR AND CELLULAR BIOLOGY
- Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer
- (2016) Yi-Ping Wang et al. MOLECULAR CELL
- Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains
- (2016) Yang Gao et al. NUCLEIC ACIDS RESEARCH
- Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
- (2016) Maxim V. Kuleshov et al. NUCLEIC ACIDS RESEARCH
- Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer
- (2016) J F Hiken et al. ONCOGENE
- A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression
- (2016) H Chen et al. ONCOGENE
- PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
- (2016) Y K Banasavadi-Siddegowda et al. ONCOGENE
- Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth
- (2016) X Deng et al. ONCOGENE
- Mapping arginine methylation in the human body and cardiac disease
- (2016) Donatus O. Onwuli et al. Proteomics Clinical Applications
- Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45
- (2016) Susann Friedrich et al. RNA
- Splicing-factor alterations in cancers
- (2016) Olga Anczuków et al. RNA
- Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
- (2016) Konstantinos J. Mavrakis et al. SCIENCE
- MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
- (2016) Gregory V. Kryukov et al. SCIENCE
- Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
- (2016) Louise J. Walport et al. Nature Communications
- The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1
- (2016) Yanyan Gao et al. Scientific Reports
- MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
- (2016) Katya Marjon et al. Cell Reports
- Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression
- (2016) Hyun-Ji Kim et al. eLife
- ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor
- (2016) Zineb Mounir et al. eLife
- PRMT5-Mediated Methylation of NF-κB p65 at Arg174 Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-α and IFN-γ Costimulation
- (2016) Daniel P. Harris et al. PLoS One
- A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases
- (2015) Mohammad S. Eram et al. ACS Chemical Biology
- Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates
- (2015) P. Ann Boriack-Sjodin et al. ACS Chemical Biology
- A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
- (2015) H. Ümit Kaniskan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Elevated protein arginine methyltransferase 1 expression regulates fibroblast motility in pulmonary fibrosis
- (2015) Dariusz Zakrzewicz et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Intron retention in mRNA: No longer nonsense
- (2015) Justin J.-L. Wong et al. BIOESSAYS
- Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
- (2015) L. Alinari et al. BLOOD
- PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)
- (2015) Tamara Ratovitski et al. CELL CYCLE
- Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation
- (2015) Jakob Fuhrmann et al. CHEMICAL REVIEWS
- Severe Hypomyelination and Developmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the Central Nervous System
- (2015) Misuzu Hashimoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation
- (2015) Qingzhu Sun et al. JOURNAL OF IMMUNOLOGY
- The protein arginine methyltransferase PRMT5 regulates Aβ-induced toxicity in human cells andCaenorhabditis elegansmodels of Alzheimer's disease
- (2015) Xin Quan et al. JOURNAL OF NEUROCHEMISTRY
- Quantitative Profiling of Post-translational Modifications by Immunoaffinity Enrichment and LC-MS/MS in Cancer Serum without Immunodepletion
- (2015) Hongbo Gu et al. MOLECULAR & CELLULAR PROTEOMICS
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
- (2015) Timothy J. Nott et al. MOLECULAR CELL
- The spliceosome is a therapeutic vulnerability in MYC-driven cancer
- (2015) Tiffany Y.-T. Hsu et al. NATURE
- MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
- (2015) Cheryl M. Koh et al. NATURE
- The promise and peril of chemical probes
- (2015) Cheryl H Arrowsmith et al. Nature Chemical Biology
- A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
- (2015) Elayne Chan-Penebre et al. Nature Chemical Biology
- A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy
- (2015) Gabriel Sanchez et al. NUCLEIC ACIDS RESEARCH
- Arginine methylation of HSP70 regulates retinoid acid-mediatedRARβ2gene activation
- (2015) Wei-wei Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology
- (2015) Zoltan Simandi et al. STEM CELLS
- FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation
- (2015) Khondker Ayesha Akter et al. TUMOR BIOLOGY
- Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
- (2015) Lorna H. Mitchell et al. ACS Medicinal Chemistry Letters
- Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666
- (2015) Kenneth W. Duncan et al. ACS Medicinal Chemistry Letters
- Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling
- (2015) Vincent Geoghegan et al. Nature Communications
- Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis
- (2015) Dong Hu et al. Nature Communications
- Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
- (2015) Li Zhang et al. eLife
- PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination
- (2015) J.-D. Kim et al. Science Advances
- MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs
- (2015) L. Wang et al. Science Advances
- Protein Arginine Methyltransferase 5 Catalyzes Substrate Dimethylation in a Distributive Fashion
- (2014) Min Wang et al. BIOCHEMISTRY
- Readers of histone methylarginine marks
- (2014) Sitaram Gayatri et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Role of vascular smooth muscle cell in the inflammation of atherosclerosis
- (2014) Soyeon Lim et al. BMB Reports
- CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis
- (2014) Lu Wang et al. CANCER CELL
- Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma
- (2014) Fengting Yan et al. CANCER RESEARCH
- PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
- (2014) R. Yao et al. CANCER RESEARCH
- Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control
- (2014) Chiao-Po Hsu et al. Cardiovascular Diabetology
- Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy
- (2014) Dongil Kim et al. CELLULAR SIGNALLING
- The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis
- (2014) Olga Zurita Rendón et al. HUMAN MOLECULAR GENETICS
- Tumor Necrosis Factor (TNF)-α Induction of CXCL10 in Endothelial Cells Requires Protein Arginine Methyltransferase 5 (PRMT5)-mediated Nuclear Factor (NF)-κB p65 Methylation
- (2014) Daniel P. Harris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Cardiomyocyte Hypertrophy by Protein Arginine Methyltransferase 5
- (2014) Ming Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo
- (2014) Min-Jung Park et al. JOURNAL OF HEPATOLOGY
- Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation
- (2014) Yanzhong Yang et al. MOLECULAR CELL
- PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
- (2014) Peter V. Hornbeck et al. NUCLEIC ACIDS RESEARCH
- Structural biology and chemistry of protein arginine methyltransferases
- (2014) Matthieu Schapira et al. MedChemComm
- A global assessment of cancer genomic alterations in epigenetic mechanisms
- (2014) Muhammad A Shah et al. Epigenetics & Chromatin
- Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway
- (2014) Takehiro Yamamoto et al. Nature Communications
- Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel
- (2013) Pedro Beltran-Alvarez et al. FEBS LETTERS
- Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery
- (2013) M. Bezzi et al. GENES & DEVELOPMENT
- Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer
- (2013) Xiangxiang Bao et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription
- (2013) S. Benhenda et al. JOURNAL OF VIROLOGY
- Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation
- (2013) Ailan Guo et al. MOLECULAR & CELLULAR PROTEOMICS
- Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome
- (2013) Michael Bremang et al. Molecular BioSystems
- Defining the RGG/RG Motif
- (2013) Palaniraja Thandapani et al. MOLECULAR CELL
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- (2013) Hong Joo Kim et al. NATURE
- Protein Arginine Methyltransferase 1 and 8 Interact with FUS to Modify Its Sub-Cellular Distribution and Toxicity In Vitro and In Vivo
- (2013) Chiara Scaramuzzino et al. PLoS One
- Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity
- (2013) Diane N Singhroy et al. Retrovirology
- Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs
- (2013) Surbhi Dhar et al. Scientific Reports
- RGG motif proteins: Modulators of mRNA functional states
- (2012) Purusharth Rajyaguru et al. CELL CYCLE
- S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications
- (2012) Anna-Winona Struck et al. CHEMBIOCHEM
- Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes
- (2012) Dennis H Dowhan et al. ENDOCRINE-RELATED CANCER
- Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
- (2012) Dariusz Zakrzewicz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
- (2012) Eva Bentmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats
- (2012) Q. Sun et al. JOURNAL OF IMMUNOLOGY
- Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
- (2012) Valentina Migliori et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Crystal structure of the human PRMT5:MEP50 complex
- (2012) S. Antonysamy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone H3R2 Symmetric Dimethylation and Histone H3K4 Trimethylation Are Tightly Correlated in Eukaryotic Genomes
- (2012) Chih-Chi Yuan et al. Cell Reports
- Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4
- (2011) M. A. Powers et al. CANCER RESEARCH
- Arginine methylation-dependent regulation of ASK1 signaling by PRMT1
- (2011) J-H Cho et al. CELL DEATH AND DIFFERENTIATION
- Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma
- (2011) Jing Zhong et al. FEBS Journal
- Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations
- (2011) Miranda L. Tradewell et al. HUMAN MOLECULAR GENETICS
- Plasma asymmetric dimethylarginine predicts death and major adverse cardiovascular events in individuals referred for coronary angiography
- (2011) Tse-Min Lu et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Type II Arginine Methyltransferase PRMT5 Regulates Gene Expression of Inhibitors of Differentiation/DNA Binding Id2 and Id4 during Glial Cell Differentiation
- (2011) Jinghan Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Chemistry of the Histone Methyltransferases Cofactor Binding Site
- (2011) Valérie Campagna-Slater et al. Journal of Chemical Information and Modeling
- Versatility of PRMT5-induced methylation in growth control and development
- (2011) Vrajesh Karkhanis et al. TRENDS IN BIOCHEMICAL SCIENCES
- MidA is a putative methyltransferase that is required for mitochondrial complex I function
- (2010) S. Carilla-Latorre et al. JOURNAL OF CELL SCIENCE
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- The art of the chemical probe
- (2010) Stephen V Frye Nature Chemical Biology
- Protein arginine methyltransferase 6 regulates multiple aspects of gene expression
- (2010) Matthew J. Harrison et al. NUCLEIC ACIDS RESEARCH
- Methylation of the Tumor Suppressor Protein, BRCA1, Influences Its Transcriptional Cofactor Function
- (2010) Irene Guendel et al. PLoS One
- Thrombospondin-1 Is a Transcriptional Repression Target of PRMT6
- (2009) Jonathan Michaud-Levesque et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arginine Methylation of the ICP27 RGG Box Regulates ICP27 Export and Is Required for Efficient Herpes Simplex Virus 1 Replication
- (2009) S. K. Souki et al. JOURNAL OF VIROLOGY
- Arginine Methylation Increases the Stability of Human Immunodeficiency Virus Type 1 Tat
- (2009) H. Sivakumaran et al. JOURNAL OF VIROLOGY
- Protein Arginine Methylation in Mammals: Who, What, and Why
- (2009) Mark T. Bedford et al. MOLECULAR CELL
- PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
- (2009) Quan Zhao et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Protein Arginine Methyltransferase 1 Coactivates NF-κB-Dependent Gene Expression Synergistically with CARM1 and PARP1
- (2008) Paul O. Hassa et al. JOURNAL OF MOLECULAR BIOLOGY
- Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells
- (2008) L. Wang et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1
- (2008) Muriel Le Romancer et al. MOLECULAR CELL
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started