Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression

Stemness and anti-cancer drug resistance in ATP-binding cassette subfamily G member 2 highly expressed pancreatic cancer is induced in 3D culture conditions

(2018) Norihiko Sasaki et al.   CANCER SCIENCE

Methylarginines within the RGG-Motif Region of hnRNP A1 Affect Its IRES Trans -Acting Factor Activity and Are Required for hnRNP A1 Stress Granule Localization and Formation

(2017) Michael L. Wall et al.   JOURNAL OF MOLECULAR BIOLOGY

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1

(2017) Guozhen Gao et al.   NUCLEIC ACIDS RESEARCH

Hippo pathway mediates resistance to cytotoxic drugs

(2017) Taranjit S. Gujral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gemcitabine upregulates ABCG2/BCRP and modulates the intracellular pharmacokinetic profiles of bioluminescence in pancreatic cancer cells

(2016) Yue Sun et al.   ANTI-CANCER DRUGS

Hypoxia regulates ABCG2activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells

(2016) Xiaodan He et al.   CANCER BIOLOGY & THERAPY

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation

(2016) Yan Wang et al.   CANCER RESEARCH

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells

(2016) Vikash J. Bhagwandin et al.   PLoS One

The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancer

(2016) Mei-Ren Pan et al.   Oncotarget

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

(2015) H. Ümit Kaniskan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

(2015) Nicolas Skrypek et al.   Oncotarget

PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents

(2015) Makoto Nakakido et al.   Oncotarget

G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation

(2015) Mei-Ren Pan et al.   Scientific Reports

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coexpression of CD44-positive/CD133-positive cancer stem cells and CD204-positive tumor-associated macrophages is a predictor of survival in pancreatic ductal adenocarcinoma

(2014) Ya-Chin Hou et al.   CANCER

PRMT3 Regulates Hepatic Lipogenesis Through Direct Interaction With LXRα

(2014) Dong-il Kim et al.   DIABETES

Profiling Substrates of Protein Arginine N-Methyltransferase 3 with S-Adenosyl-l-methionine Analogues

(2013) Han Guo et al.   ACS Chemical Biology

ABCB2 (TAP1) as the downstream target of SHH signaling enhances pancreatic ductal adenocarcinoma drug resistance

(2013) Min Xu et al.   CANCER LETTERS

Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors

(2013) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells

(2011) Wei-Chien Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

(2011) Jung-Mao Hsu et al.   NATURE CELL BIOLOGY

Regulation of Deoxycytidine Kinase Expression and Sensitivity to Gemcitabine by Micro-RNA 330 and Promoter Methylation in Cancer Cells

(2011) Jasmina Hodzic et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Expression and promoter methylation analysis of ATP-binding cassette genes in pancreatic cancer

(2011) Yi Miao   ONCOLOGY REPORTS

PRMT3 is essential for dendritic spine maturation in rat hippocampal neurons

(2010) Shingo Miyata et al.   BRAIN RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Gemcitabine chemoresistance in pancreatic cancer: Molecular mechanisms and potential solutions

(2009) Roland Andersson et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Human Multidrug Resistance Protein 7 (ABCC10) Is a Resistance Factor for Nucleoside Analogues and Epothilone B

(2008) E. Hopper-Borge et al.   CANCER RESEARCH

Regulation of Pancreatic Tumor Cell Proliferation and Chemoresistance by the Histone Methyltransferase Enhancer of Zeste Homologue 2

(2008) A. V. Ougolkov et al.   CLINICAL CANCER RESEARCH

Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer

(2008) James J. Farrell et al.   GASTROENTEROLOGY

Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides

(2008) C. de Wolf et al.   MOLECULAR CANCER THERAPEUTICS

Persistence of side population cells with high drug efflux capacity in pancreatic cancer

(2008) Jing Zhou   WORLD JOURNAL OF GASTROENTEROLOGY