Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

Rethinking graduate education

(2015) A. I. Leshner   SCIENCE

Alternative mRNA transcription, processing, and translation: insights from RNA sequencing

(2015) Eleonora de Klerk et al.   TRENDS IN GENETICS

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

(2015) Benoit Moindrot et al.   Cell Reports

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia

(2014) C. Wang et al.   BLOOD

Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl

(2014) N. Xiao et al.   BLOOD

Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice

(2014) Y. Komeno et al.   BLOOD

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

(2014) Henrike Maatz et al.   JOURNAL OF CLINICAL INVESTIGATION

Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1

(2014) Leilei Yan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chromatin modifiers and the promise of epigenetic therapy in acute leukemia

(2014) S M Greenblatt et al.   LEUKEMIA

A Methylation-Phosphorylation Switch Determines Sox2 Stability and Function in ESC Maintenance or Differentiation

(2014) Lan Fang et al.   MOLECULAR CELL

An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma

(2014) Maria Giuseppina Baratta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional diversity during lineage commitment of human blood progenitors

(2014) L. Chen et al.   SCIENCE

RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells

(2013) D. Ran et al.   BLOOD

A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells

(2013) Rui Wang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

(2013) M. Bezzi et al.   GENES & DEVELOPMENT

Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

(2013) Keiko Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

(2013) Ailan Guo et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

(2013) Surbhi Dhar et al.   Scientific Reports

PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex

(2013) Ly P. Vu et al.   Cell Reports

Current Chemical Biology Approaches to Interrogate Protein Methyltransferases

(2012) Minkui Luo   ACS Chemical Biology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

(2012) E. C. Smith et al.   BLOOD

Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms

(2012) M. Cazzola et al.   BLOOD

PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential

(2012) W.-J. Shia et al.   BLOOD

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

(2012) M. E. McNerney et al.   BLOOD

Alternatively spliced protein arginine methyltransferase 1 isoform PRMT1v2 promotes the survival and invasiveness of breast cancer cells

(2012) R. Mitchell Baldwin et al.   CELL CYCLE

Ccr4-Not complex: the control freak of eukaryotic cells

(2012) Jason E. Miller et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes

(2012) Yuan Gao et al.   DEVELOPMENTAL CELL

Detecting differential usage of exons from RNA-seq data

(2012) S. Anders et al.   GENOME RESEARCH

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

(2012) Gabriel B. Loeb et al.   MOLECULAR CELL

HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

(2012) Frederik Otzen Bagger et al.   NUCLEIC ACIDS RESEARCH

Rbm15-Mkl1 Interacts with the Setd1b Histone H3-Lys4 Methyltransferase via a SPOC Domain That Is Required for Cytokine-Independent Proliferation

(2012) Jeong-Heon Lee et al.   PLoS One

PRMT1 is required for RAP55 to localize to processing bodies

(2012) Ken Matsumoto et al.   RNA Biology

Expansion of functionally defined mouse hematopoietic stem and progenitor cells by a short isoform of RUNX1/AML1

(2011) S. Tsuzuki et al.   BLOOD

Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators

(2011) Marloes R. Tijssen et al.   DEVELOPMENTAL CELL

Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations

(2011) Miranda L. Tradewell et al.   HUMAN MOLECULAR GENETICS

Labeling Substrates of Protein Arginine Methyltransferase with Engineered Enzymes and MatchedS-Adenosyl-l-methionine Analogues

(2011) Rui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

The Ccr4-Not Complex Interacts with the mRNA Export Machinery

(2011) Shana C. Kerr et al.   PLoS One

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

The Spen Family Protein FPA Controls Alternative Cleavage and Polyadenylation of RNA

(2010) Csaba Hornyik et al.   DEVELOPMENTAL CELL

Arginine Methylation Controls the Subcellular Localization and Functions of the Oncoprotein Splicing Factor SF2/ASF

(2010) Rahul Sinha et al.   MOLECULAR AND CELLULAR BIOLOGY

Analysis and design of RNA sequencing experiments for identifying isoform regulation

(2010) Yarden Katz et al.   NATURE METHODS

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Human Ccr4–Not complexes contain variable deadenylase subunits

(2009) Nga-Chi Lau et al.   BIOCHEMICAL JOURNAL

c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development

(2009) C. Niu et al.   BLOOD

Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression

(2009) D. P. Mersman et al.   GENES & DEVELOPMENT

The RNA-binding Motif Protein 15B (RBM15B/OTT3) Acts as Cofactor of the Nuclear Export Receptor NXF1

(2009) Hiroaki Uranishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

(2009) X Liu et al.   LEUKEMIA

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA

(2009) Andrei S. Zolotukhin et al.   NUCLEIC ACIDS RESEARCH

Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes

(2008) R. Tiedt et al.   BLOOD

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

(2008) X. Zhao et al.   GENES & DEVELOPMENT

Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen

(2008) G. D. Raffel et al.   MOLECULAR AND CELLULAR BIOLOGY

Bromodomain 4 activation predicts breast cancer survival

(2008) N. P. S. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of Signal Transducer and Activator of Transcription 5 (STAT5) in CD34+Cells Promotes Megakaryocytic Development, Whereas Activation of STAT5 Drives Erythropoiesis

(2008) Sandra G. Olthof et al.   STEM CELLS

The RNA transport element RTE is essential for IAP LTR-retrotransposon mobility

(2008) Andrei S. Zolotukhin et al.   VIROLOGY

Spenito and Split ends act redundantly to promote Wingless signaling

(2007) Jinhee L. Chang et al.   DEVELOPMENTAL BIOLOGY