Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

(2015) L. Alinari et al.   BLOOD

Targeting molecular resistance in castration-resistant prostate cancer

(2015) Thenappan Chandrasekar et al.   BMC Medicine

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

(2015) S S Tarighat et al.   LEUKEMIA

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells

(2015) Colin W. Hay et al.   PLoS One

Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells

(2014) Huan-Tian Zhang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

(2014) Fengting Yan et al.   CANCER RESEARCH

Novel Mechanism of Negative Regulation of 1,25-Dihydroxyvitamin D3-induced 25-Hydroxyvitamin D324-Hydroxylase (Cyp24a1) Transcription

(2014) Tanya Seth-Vollenweider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen Receptor Splice Variants in the Era of Enzalutamide and Abiraterone

(2014) Mary Nakazawa et al.   Hormones & Cancer

SMYD3 as an Oncogenic Driver in Prostate Cancer by Stimulation of Androgen Receptor Transcription

(2013) Cheng Liu et al.   JNCI-Journal of the National Cancer Institute

Transcriptional activity of c-Jun is critical for the suppression of AR function

(2013) Chih-Chao Hsu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

(2012) Zhongping Gu et al.   BIOCHEMICAL JOURNAL

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

(2012) Tong-You W. Wei et al.   CANCER SCIENCE

Arginine methylation controls growth regulation by E2F-1

(2012) Er-Chieh Cho et al.   EMBO JOURNAL

A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!

(2012) Zhiyong Guo et al.   International Journal of Biological Sciences

Protein Arginine Methyltransferase 5 (Prmt5) Promotes Gene Expression of Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) and Its Target Genes during Adipogenesis

(2012) Scott E. LeBlanc et al.   MOLECULAR ENDOCRINOLOGY

Androgen Receptor Drives Cellular Senescence

(2012) Yelena Mirochnik et al.   PLoS One

Protein Arginine Methyltransferase 5 Functions in Opposite Ways in the Cytoplasm and Nucleus of Prostate Cancer Cells

(2012) Zhongping Gu et al.   PLoS One

Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4

(2011) M. A. Powers et al.   CANCER RESEARCH

Single-vector inducible lentiviral RNAi system for oncology target validation

(2011) Dmitri Wiederschain et al.   CELL CYCLE

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

(2011) Diana C Hargreaves et al.   CELL RESEARCH

Epigenetics in Prostate Cancer: Biologic and Clinical Relevance

(2011) Carmen Jerónimo et al.   EUROPEAN UROLOGY

Androgen Receptor Rediscovered: The New Biology and Targeting the Androgen Receptor Therapeutically

(2011) Charles J. Ryan et al.   JOURNAL OF CLINICAL ONCOLOGY

Versatility of PRMT5-induced methylation in growth control and development

(2011) Vrajesh Karkhanis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Prognostic Value and Function of KLF4 in Prostate Cancer: RNAa and Vector-Mediated Overexpression Identify KLF4 as an Inhibitor of Tumor Cell Growth and Migration

(2010) J. Wang et al.   CANCER RESEARCH

Epigenetic regulation of androgen receptor signaling in prostate cancer

(2010) Lina Gao et al.   Epigenetics

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

(2010) W.-W. Tee et al.   GENES & DEVELOPMENT

Molecular mechanisms of castration-resistant prostate cancer progression

(2009) Smitha S Dutt et al.   Future Oncology

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells

(2008) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY