The PAF complex regulation of Prmt5 facilitates the progression and maintenance of MLL fusion leukemia

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

(2016) Ngai Cheung et al.   CANCER CELL

Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia

(2016) Yanli Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6

(2016) S. Branden Van Oss et al.   MOLECULAR CELL

MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

(2016) Gregory V. Kryukov et al.   SCIENCE

Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia

(2016) Lili Chen et al.   Oncotarget

Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes

(2016) Maria-Paz Garcia-Cuellar et al.   Cell Reports

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

(2016) Katya Marjon et al.   Cell Reports

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

(2015) Fei Xavier Chen et al.   CELL

Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumorigenesis

(2015) Hao Zeng et al.   GENES & DEVELOPMENT

Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

(2015) Fan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin

(2015) Baolai Zhang et al.   Journal of Translational Medicine

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

(2015) S S Tarighat et al.   LEUKEMIA

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

(2015) L Chen et al.   LEUKEMIA

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

(2015) Chun-Wei Chen et al.   NATURE MEDICINE

Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets

(2015) C T Collins et al.   ONCOGENE

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers

(2015) Y. Li et al.   Cancer Discovery

Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells

(2015) Maria Patrizia Mongiardi et al.   Scientific Reports

CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

(2014) Lu Wang et al.   CANCER CELL

Non-reciprocal and highly nonlinear active acoustic metamaterials

(2014) Bogdan-Ioan Popa et al.   Nature Communications

MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction

(2013) A. G. Muntean et al.   BLOOD

Threshold Insulin-Pump Interruption to Reduce Hypoglycemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome

(2013) Michael Girardot et al.   NUCLEIC ACIDS RESEARCH

PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

(2013) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex

(2013) Ly P. Vu et al.   Cell Reports

The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states

(2012) Brett N. Tomson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential

(2012) W.-J. Shia et al.   BLOOD

HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules

(2012) S. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

(2012) Valentina Migliori et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

(2011) Y. Huang et al.   BLOOD

Human RNA Polymerase II-Association Factor 1 (hPaf1/PD2) Regulates Histone Methylation and Chromatin Remodeling in Pancreatic Cancer

(2011) Parama Dey et al.   PLoS One

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

(2011) N. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Paf1 complex: Platform or player in RNA polymerase II transcription?

(2010) Judith A. Jaehning   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

The Human PAF1 Complex Acts in Chromatin Transcription Elongation Both Independently and Cooperatively with SII/TFIIS

(2010) Jaehoon Kim et al.   CELL

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

(2010) W.-W. Tee et al.   GENES & DEVELOPMENT

Cell division cycle protein 73 homolog (CDC73) mutations in the hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid tumors

(2010) Paul J. Newey et al.   HUMAN MUTATION

Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis

(2010) Thomas A. Milne et al.   MOLECULAR CELL

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

(2010) Johannes Zuber et al.   NATURE BIOTECHNOLOGY

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells

(2008) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY