MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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Title
MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
Authors
Keywords
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Journal
CANCER CELL
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-01-15
DOI
10.1016/j.ccell.2020.12.010
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Related references
Note: Only part of the references are listed.- Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
- (2020) Mu-Yan Cai et al. Cell Reports
- Regulation of R-loops and genome instability in Fanconi anemia
- (2019) Yusuke Okamoto et al. JOURNAL OF BIOCHEMISTRY
- Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization
- (2017) Ruifeng Mao et al. JOURNAL OF MEDICINAL CHEMISTRY
- A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML
- (2017) L M Kats et al. LEUKEMIA
- Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases
- (2017) Lakshmi Prabhu et al. Molecular BioSystems
- Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
- (2017) Casey L Quinlan et al. Nature Chemical Biology
- Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity
- (2017) Gui-Mei Kong et al. PLoS One
- SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage
- (2017) Mohini Jangi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
- (2017) Katharine Yen et al. Cancer Discovery
- Combination therapy in combating cancer
- (2017) Reza Bayat Mokhtari et al. Oncotarget
- The DNA fibre technique – tracking helicases at work
- (2016) Jadwiga Nieminuszczy et al. METHODS
- Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
- (2016) Marc Hafner et al. NATURE METHODS
- COSMIC: somatic cancer genetics at high-resolution
- (2016) Simon A. Forbes et al. NUCLEIC ACIDS RESEARCH
- Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
- (2016) Konstantinos J. Mavrakis et al. SCIENCE
- MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
- (2016) Gregory V. Kryukov et al. SCIENCE
- MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
- (2016) Katya Marjon et al. Cell Reports
- RNase H enables efficient repair of R-loop induced DNA damage
- (2016) Jeremy D Amon et al. eLife
- The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing
- (2016) M Tanikawa et al. Oncogenesis
- Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
- (2015) L. Alinari et al. BLOOD
- FANCA safeguards interphase and mitosis during hematopoiesis in vivo
- (2015) Zahi Abdul-Sater et al. EXPERIMENTAL HEMATOLOGY
- Detained introns are a novel, widespread class of post-transcriptionally spliced introns
- (2015) Paul L. Boutz et al. GENES & DEVELOPMENT
- Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell killing
- (2015) Yihan Wan et al. JOURNAL OF CELL BIOLOGY
- Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis
- (2015) Fan Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription
- (2015) Rebekka A. Schwab et al. MOLECULAR CELL
- SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
- (2015) Dorothy Yanling Zhao et al. NATURE
- A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
- (2015) Elayne Chan-Penebre et al. Nature Chemical Biology
- Discovery of a Dual PRMT5–PRMT7 Inhibitor
- (2015) David Smil et al. ACS Medicinal Chemistry Letters
- Performance comparison of four commercial human whole-exome capture platforms
- (2015) Daichi Shigemizu et al. Scientific Reports
- The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
- (2015) María L. García-Rubio et al. PLoS Genetics
- Translational Exposure-Efficacy Modeling to Optimize the Dose and Schedule of Taxanes Combined with the Investigational Aurora A Kinase Inhibitor MLN8237 (Alisertib)
- (2014) J. J. Huck et al. MOLECULAR CANCER THERAPEUTICS
- Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability
- (2014) Julie Sollier et al. MOLECULAR CELL
- Loss ofCDKN2Aexpression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines
- (2014) Richard J. Young et al. Pigment Cell & Melanoma Research
- rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data
- (2014) Shihao Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery
- (2013) M. Bezzi et al. GENES & DEVELOPMENT
- Fanconi anemia signaling network regulates the spindle assembly checkpoint
- (2013) Grzegorz Nalepa et al. JOURNAL OF CLINICAL INVESTIGATION
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff
- (2012) Pablo Cingolani et al. FLY
- Detecting differential usage of exons from RNA-seq data
- (2012) S. Anders et al. GENOME RESEARCH
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells
- (2012) L. Cen et al. NEURO-ONCOLOGY
- Crystal structure of the human PRMT5:MEP50 complex
- (2012) S. Antonysamy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity
- (2011) Joseph R. Bertino et al. CANCER BIOLOGY & THERAPY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Metabolomic Analysis and Visualization Engine for LC−MS Data
- (2010) Eugene Melamud et al. ANALYTICAL CHEMISTRY
- Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency
- (2010) W.-W. Tee et al. GENES & DEVELOPMENT
- Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells
- (2010) Patrizia Vinciguerra et al. JOURNAL OF CLINICAL INVESTIGATION
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability
- (2009) Renee D. Paulsen et al. MOLECULAR CELL
- Replication stress induces sister-chromatid bridging at fragile site loci in mitosis
- (2009) Kok Lung Chan et al. NATURE CELL BIOLOGY
- The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities
- (2009) Valeria Naim et al. NATURE CELL BIOLOGY
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