PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

A patent review of arginine methyltransferase inhibitors (2010-2018)

(2019) Xiao Li et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

(2019) Daniele Musiani et al.   Science Signaling

PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

(2018) Pierre-Jacques Hamard et al.   Cell Reports

Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer

(2018) Harshita Shailesh et al.   Oncotarget

Intron retention as a component of regulated gene expression programs

(2017) Aishwarya G. Jacob et al.   HUMAN GENETICS

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML

(2017) S Kaushik et al.   LEUKEMIA

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

(2017) Madhumitha Rengasamy et al.   NUCLEIC ACIDS RESEARCH

The ribosome-engaged landscape of alternative splicing

(2016) Robert J Weatheritt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression

(2016) Aliaksandra Radzisheuskaya et al.   NUCLEIC ACIDS RESEARCH

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

(2016) Konstantinos J. Mavrakis et al.   SCIENCE

MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

(2016) Gregory V. Kryukov et al.   SCIENCE

Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells

(2016) Sara C. Larsen et al.   Science Signaling

The ribosome-engaged landscape of alternative splicing

(2016) Robert J Weatheritt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

(2016) Katya Marjon et al.   Cell Reports

Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells

(2016) Sara C. Larsen et al.   Science Signaling

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Detained introns are a novel, widespread class of post-transcriptionally spliced introns

(2015) Paul L. Boutz et al.   GENES & DEVELOPMENT

Histone H2A and H4 N-terminal Tails Are Positioned by the MEP50 WD Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase

(2015) Emmanuel S. Burgos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

(2015) Cheryl M. Koh et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Readers of histone methylarginine marks

(2014) Sitaram Gayatri et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Emerging Functions of SRSF1, Splicing Factor and Oncoprotein, in RNA Metabolism and Cancer

(2014) S. Das et al.   MOLECULAR CANCER RESEARCH

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

(2013) M. Bezzi et al.   GENES & DEVELOPMENT

Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins

(2013) ShengQi Xiang et al.   STRUCTURE

Isobaric tagging approaches in quantitative proteomics: the ups and downs

(2012) Andy L. Christoforou et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Detecting differential usage of exons from RNA-seq data

(2012) S. Anders et al.   GENOME RESEARCH

Crystal structure of the human PRMT5:MEP50 complex

(2012) S. Antonysamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shuttling SR proteins: more than splicing factors

(2011) Laure Twyffels et al.   FEBS Journal

Arginine Methylation Controls the Subcellular Localization and Functions of the Oncoprotein Splicing Factor SF2/ASF

(2010) Rahul Sinha et al.   MOLECULAR AND CELLULAR BIOLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS