Emerging concepts in the science of vaccine adjuvants

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial

(2021) Raches Ella et al.   LANCET INFECTIOUS DISEASES

Modeling human adaptive immune responses with tonsil organoids

(2021) Lisa E. Wagar et al.   NATURE MEDICINE

Toward precision adjuvants

(2020) Etsuro Nanishi et al.   CURRENT OPINION IN PEDIATRICS

Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus

(2020) Yuri Kotliarov et al.   NATURE MEDICINE

Engineered immunogen binding to alum adjuvant enhances humoral immunity

(2020) Tyson J. Moyer et al.   NATURE MEDICINE

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

(2020) Prabhu S. Arunachalam et al.   NATURE MEDICINE

Controlling timing and location in vaccines

(2020) Darrell J. Irvine et al.   ADVANCED DRUG DELIVERY REVIEWS

The Impact of the Microbiome on Immunity to Vaccination in Humans

(2020) Sanne E. de Jong et al.   Cell Host & Microbe

Shaping humoral immunity to vaccines through antigen-displaying nanoparticles

(2020) Darrell J Irvine et al.   CURRENT OPINION IN IMMUNOLOGY

Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

(2020) Ali H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

(2020) Eui Ho Kim et al.   eLife

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates

(2020) Sudhir Pai Kasturi et al.   Science Immunology

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

(2020) Shengli Xia et al.   LANCET INFECTIOUS DISEASES

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity

(2020) Gillie A. Roth et al.   ACS Central Science

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

(2020) Yanjun Zhang et al.   LANCET INFECTIOUS DISEASES

Post-hoc analysis from phase III trials of human papillomavirus vaccines: considerations on impact on non-vaccine types

(2019) Martin Ryser et al.   Expert Review of Vaccines

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Therapeutic targeting of trained immunity

(2019) Willem J. M. Mulder et al.   NATURE REVIEWS DRUG DISCOVERY

Cell Death and Inflammation – A Vital but Dangerous Liaison

(2019) Nieves Peltzer et al.   TRENDS IN IMMUNOLOGY

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans

(2019) Thomas Hagan et al.   CELL

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

(2019) Joel Zindel et al.   Annual Review of Pathology-Mechanisms of Disease

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases

(2019) Ming-Ming Hu et al.   Annual Review of Immunology

Adjuvant effect of TLR7 agonist adsorbed on aluminum hydroxide (AS37): A phase I randomized, dose escalation study of an AS37-adjuvanted meningococcal C conjugated vaccine

(2019) Antonio Gonzalez-Lopez et al.   CLINICAL IMMUNOLOGY

Inflammasomes and the fine line between defense and disease

(2019) Shelbi Christgen et al.   CURRENT OPINION IN IMMUNOLOGY

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

(2019) Marie Jo Halaby et al.   Science Immunology

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

(2018) Rob J.W. Arts et al.   Cell Host & Microbe

Adjuvant strategies to improve vaccination of the elderly population

(2018) Birgit Weinberger   CURRENT OPINION IN PHARMACOLOGY

A Two-Dose Hepatitis B Vaccine for Adults (Heplisav-B)

(2018)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Stable Nanoemulsions for the Delivery of Small Molecule Immune Potentiators

(2018) Rushit N. Lodaya et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)

(2018) Dan H Barouch et al.   LANCET

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

(2018) Carole Henry et al.   TRENDS IN IMMUNOLOGY

C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets

(2018) Elise Chiffoleau   Frontiers in Immunology

RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections

(2018) Hui Yee Yong et al.   Frontiers in Immunology

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

(2018) Charlotte Givord et al.   npj Vaccines

AS03 stresses out macrophages: Commentary on ‘Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties’

(2018) Mark T. Orr et al.   npj Vaccines

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair

(2018) Giulia De Lorenzo et al.   TRENDS IN IMMUNOLOGY

Adjuvants Enhancing Cross-Presentation by Dendritic Cells: The Key to More Effective Vaccines?

(2018) Nataschja I. Ho et al.   Frontiers in Immunology

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

(2018) Harm HogenEsch et al.   npj Vaccines

Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses

(2017) Abhishek Das et al.   IMMUNITY

B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle

(2017) Meijie Tian et al.   JOURNAL OF IMMUNOLOGY

The Doctrine of Original Antigenic Sin: Separating Good From Evil

(2017) Arnold S. Monto et al.   JOURNAL OF INFECTIOUS DISEASES

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

(2017) Dmitri Kazmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

(2017) Charles Sinclair et al.   SCIENCE

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

(2017) Frank Liang et al.   Science Translational Medicine

Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens?

(2017) Nicholas Collins et al.   Cold Spring Harbor Perspectives in Biology

Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients

(2017) Chenliang Zhou et al.   Human Vaccines & Immunotherapeutics

Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?

(2017) Juan I. Moliva et al.   Frontiers in Immunology

Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans

(2017) Wivine Burny et al.   Frontiers in Immunology

Predicting RTS,S Vaccine-Mediated Protection from Transcriptomes in a Malaria-Challenge Clinical Trial

(2017) Robert A. van den Berg et al.   Frontiers in Immunology

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

(2017) Margherita Coccia et al.   npj Vaccines

Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial

(2017) Leigh M. Howard et al.   PLoS One

A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines

(2017) Neal Van Hoeven et al.   Scientific Reports

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Impact of adjuvants on CD4 + T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial

(2016) Geert Leroux-Roels et al.   CLINICAL IMMUNOLOGY

An Updated Review of ISCOMSTM and ISCOMATRIXTM Vaccines

(2016) Alexis Garcia et al.   CURRENT PHARMACEUTICAL DESIGN

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

(2016) Arnaud M. Didierlaurent et al.   Expert Review of Vaccines

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Strategies for designing synthetic immune agonists

(2016) Tom Y.-H. Wu   IMMUNOLOGY

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

(2016) Christopher B. Fox et al.   JOURNAL OF CONTROLLED RELEASE

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines

(2016) Laura E. Noges et al.   JOURNAL OF IMMUNOLOGY

Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide

(2016) Alex Cortez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

(2016) Sudhir Pai Kasturi et al.   JOURNAL OF VIROLOGY

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

(2016) Olga Sobolev et al.   NATURE IMMUNOLOGY

Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children

(2016) Ally Olotu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

(2016) Hok Hei Tam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood

(2016) Helder I. Nakaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

From discovery to licensure, the Adjuvant System story

(2016) Nathalie Garçon et al.   Human Vaccines & Immunotherapeutics

RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection

(2016) Matheswaran Kandasamy et al.   PLoS Pathogens

Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen

(2016) Alex C. D. Salyer et al.   PLoS One

Central Role of CD169+ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01

(2016) Sophie Detienne et al.   Scientific Reports

The Varieties of Immunological Experience: Of Pathogens, Stress, and Dendritic Cells

(2015) Bali Pulendran   Annual Review of Immunology

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

(2015) Helder I. Nakaya et al.   IMMUNITY

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

(2015) Robyn Marty-Roix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-Resident Memory T Cells and Fixed Immune Surveillance in Nonlymphoid Organs

(2015) Francis R. Carbone   JOURNAL OF IMMUNOLOGY

Vaccine Adjuvant MF59 Promotes Retention of Unprocessed Antigen in Lymph Node Macrophage Compartments and Follicular Dendritic Cells

(2015) Rocco Cantisani et al.   JOURNAL OF IMMUNOLOGY

Innate immune memory: a paradigm shift in understanding host defense

(2015) Mihai G Netea et al.   NATURE IMMUNOLOGY

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

(2015) Himal Lal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination

(2015) Rama S. Akondy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Superior antigen-specific CD4+T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older

(2014) Robert B Couch et al.   BMC INFECTIOUS DISEASES

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Designing and building the next generation of improved vaccine adjuvants

(2014) Luis A. Brito et al.   JOURNAL OF CONTROLLED RELEASE

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells

(2014) A. Seubert et al.   JOURNAL OF IMMUNOLOGY

Emerging functions of the unfolded protein response in immunity

(2014) Sophie Janssens et al.   NATURE IMMUNOLOGY

Systems vaccinology: Probing humanity's diverse immune systems with vaccines

(2014) B. Pulendran   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

(2014) C. Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design of small molecules as vaccine adjuvants

(2014) T. Y.- H. Wu et al.   Science Translational Medicine

Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine

(2014) Paulo S Naud et al.   Human Vaccines & Immunotherapeutics

Human dendritic cells subsets as targets and vectors for therapy

(2013) Eynav Klechevsky et al.   Annals of the New York Academy of Sciences

Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines

(2013) Gerlinde Obermoser et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

(2013) D. Furman et al.   Molecular Systems Biology

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

(2013) Shuzhao Li et al.   NATURE IMMUNOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

(2013) M. Vono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

(2013) A. S. McKee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence

(2013) Vasudev R Rao et al.   Retrovirology

Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation

(2013) R. Ravindran et al.   SCIENCE

Immunogenicity and safety of an investigational hepatitis B vaccine with a Toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared to a licensed hepatitis B vaccine in healthy adults 40–70 years of age

(2013) William L. Heyward et al.   VACCINE

Development of replication-competent viral vectors for HIV vaccine delivery

(2013) Christopher L. Parks et al.   Current Opinion in HIV and AIDS

Integrative genomic analysis of the human immune response to influenza vaccination

(2013) Luis M Franco et al.   eLife

The Dendritic Cell Response to Classic, Emerging, and Homeostatic Danger Signals. Implications for Autoimmunity

(2013) Paul M. Gallo et al.   Frontiers in Immunology

Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

(2012) Nathalie Garçon et al.   Expert Review of Vaccines

The history of MF59®adjuvant: a phoenix that arose from the ashes

(2012) Derek T O’Hagan et al.   Expert Review of Vaccines

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

Development of an AS04-Adjuvanted HPV Vaccine with the Adjuvant System Approach

(2011) Nathalie Garçon et al.   BIODRUGS

TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway

(2011) J. Z. Oh et al.   BLOOD

Selective effects of NF-κB1 deficiency in CD4+ T cells on Th2 and TFh induction by alum-precipitated protein vaccines

(2011) Karine Serre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The long-term potential of biodegradable poly(lactideco-glycolide) microparticles as the next-generation vaccine adjuvant

(2011) Siddhartha Jain et al.   Expert Review of Vaccines

Antigen depot is not required for alum adjuvanticity

(2011) Sharon Hutchison et al.   FASEB JOURNAL

Quantitative review of antibody response to inactivated seasonal influenza vaccines

(2011) Jessica C. Seidman et al.   Influenza and Other Respiratory Viruses

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

(2011) Sanae Sasaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

(2011) I. Jelinek et al.   JOURNAL OF IMMUNOLOGY

Memory CD4 T Cells That Express CXCR5 Provide Accelerated Help to B Cells

(2011) M. K. L. MacLeod et al.   JOURNAL OF IMMUNOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

(2011) A. Seubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59

(2011) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

(2011) J. Idoyaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Newborn and Infant Vaccines

(2011) G. Sanchez-Schmitz et al.   Science Translational Medicine

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

(2011) Samuele Calabro et al.   VACCINE

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity

(2011) Sandra Morel et al.   VACCINE

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

(2010) M. W. Munks et al.   BLOOD

Systems Vaccinology

(2010) Bali Pulendran et al.   IMMUNITY

Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation

(2010) Alexandre Garin et al.   IMMUNITY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Identification of Novel Synthetic Toll-like Receptor 2 Agonists by High Throughput Screening

(2010) Yue Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Genes Associated with Immunoproteasome Processing of Major Histocompatibility Complex Peptides Is Indicative of Protection with Adjuvanted RTS,S Malaria Vaccine

(2010) Maryanne T. Vahey et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of small peptides mimicking the R2C-terminus ofMycobacterium tuberculosisribonucleotide reductase

(2010) Daniel J. Ericsson et al.   JOURNAL OF PEPTIDE SCIENCE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

(2009) John D. Campbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Alum adjuvanticity: Unraveling a century old mystery

(2008) Ennio De Gregorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

(2008) Joseph D. Miller et al.   IMMUNITY

Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms

(2008) Baidong Hou et al.   IMMUNITY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

(2008) Denis Gaucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

Molecular and cellular signatures of human vaccine adjuvants

(2008) F. Mosca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA