A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines

Assessment of Prime-boost Vaccination Using an AS03B-adjuvanted Influenza A (H5N1) Vaccine

(2016) Patricia Izurieta et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Development of a high density hemagglutinin protein microarray to determine the breadth of influenza antibody responses

(2016) Anthony L. Desbien et al.   BIOTECHNIQUES

Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant

(2015) Wilbur H. Chen et al.   Clinical and Vaccine Immunology

The avian influenza vaccine Emerflu. Why did it fail?

(2015) Barnaby E Young et al.   Expert Review of Vaccines

Imiquimod in cervical, vaginal and vulvar intraepithelial neoplasia: A review

(2015) C.J. de Witte et al.   GYNECOLOGIC ONCOLOGY

Phase II, randomized, open, controlled study of AS03-adjuvanted H5N1 pre-pandemic influenza vaccine in children aged 3 to 9 years: follow-up of safety and immunogenicity persistence at 24 months post-vaccination

(2015) Javier Díez-Domingo et al.   Influenza and Other Respiratory Viruses

The Development of Self-Emulsifying Oil-in-Water Emulsion Adjuvant and an Evaluation of the Impact of Droplet Size on Performance

(2015) Ruchi R. Shah et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses

(2015) Peter H. Goff et al.   JOURNAL OF VIROLOGY

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

(2015) Geoffrey M Lynn et al.   NATURE BIOTECHNOLOGY

Use of recombinant flagellin in oil-in-water emulsions enhances hemagglutinin-specific mucosal IgA production and IL-17 secreting T cells against H5N1 avian influenza virus infection

(2015) Chih-Hsuan Lai et al.   VACCINE

Immunogenicity and safety of AS03A-adjuvanted H5N1 influenza vaccine prepared from bulk antigen after stockpiling for 4 years

(2015) Olivier Godeaux et al.   VACCINE

Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge

(2015) Freek Cox et al.   PLoS One

Toll-Like Receptor 7 Agonist Imiquimod in Combination with Influenza Vaccine Expedites and Augments Humoral Immune Responses against Influenza A(H1N1)pdm09 Virus Infection in BALB/c Mice

(2014) Anna J. X. Zhang et al.   Clinical and Vaccine Immunology

Improving pandemic H5N1 influenza vaccines by combining different vaccine platforms

(2014) Catherine J Luke et al.   Expert Review of Vaccines

Immunogenicity of Avian Influenza A/Anhui/01/2005(H5N1) Vaccine With MF59 Adjuvant

(2014) Robert B. Belshe et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Elimination of the cold-chain dependence of a nanoemulsion adjuvanted vaccine against tuberculosis by lyophilization

(2014) Mark T. Orr et al.   JOURNAL OF CONTROLLED RELEASE

Heterologous Prime-Boost Vaccination Using an AS03B-Adjuvanted Influenza A(H5N1) Vaccine in Infants and Children

(2014) Terry Nolan et al.   JOURNAL OF INFECTIOUS DISEASES

AS03B-Adjuvanted H5N1 Influenza Vaccine in Children 6 Months Through 17 Years of Age: A Phase 2/3 Randomized, Placebo-Controlled, Observer-Blinded Trial

(2014) Pope Kosalaraksa et al.   JOURNAL OF INFECTIOUS DISEASES

Activation of the RIG-I Pathway during Influenza Vaccination Enhances the Germinal Center Reaction, Promotes T Follicular Helper Cell Induction, and Provides a Dose-Sparing Effect and Protective Immunity

(2014) R. R. Kulkarni et al.   JOURNAL OF VIROLOGY

GLA-AF, an Emulsion-Free Vaccine Adjuvant for Pandemic Influenza

(2014) Christopher H. Clegg et al.   PLoS One

Heterologous Prime-Boost Vaccination with MF59-Adjuvanted H5 Vaccines Promotes Antibody Affinity Maturation towards the Hemagglutinin HA1 Domain and Broad H5N1 Cross-Clade Neutralization

(2014) Surender Khurana et al.   PLoS One

Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination

(2014) Gabriel Kristian Pedersen et al.   VACCINE

Immunological assessment of influenza vaccines and immune correlates of protection

(2013) Adrian Reber et al.   Expert Review of Vaccines

An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants

(2013) Christopher B Fox et al.   Expert Review of Vaccines

The use of Toll-like receptor 7/8 agonists as vaccine adjuvants

(2013) John P Vasilakos et al.   Expert Review of Vaccines

H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet

(2013) Y. Zhang et al.   SCIENCE

Natural history of highly pathogenic avian influenza H5N1

(2013) Stephanie Sonnberg et al.   VIRUS RESEARCH

The emergence and diversification of panzootic H5N1 influenza viruses

(2013) Yi Guan et al.   VIRUS RESEARCH

A phase II study of an investigational tetravalent influenza vaccine formulation combining MF59®

(2013) Karl-Heinz Herbinger et al.   Human Vaccines & Immunotherapeutics

Assessment of Antigen-Specific and Cross-Reactive Antibody Responses to an MF59-Adjuvanted A/H5N1 Prepandemic Influenza Vaccine in Adult and Elderly Subjects

(2012) Iván Bihari et al.   Clinical and Vaccine Immunology

Adjuvants for human vaccines

(2012) Carl R Alving et al.   CURRENT OPINION IN IMMUNOLOGY

An assessment of prime-boost vaccination schedules with AS03A-adjuvanted prepandemic H5N1 vaccines: a randomized study in European adults

(2012) Paul Gillard et al.   Influenza and Other Respiratory Viruses

Adjuvant solution for pandemic influenza vaccine production

(2012) C. H. Clegg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Flagellin-HA vaccines protect ferrets and mice against H5N1 highly pathogenic avian influenza virus (HPAIV) infections

(2012) Ge Liu et al.   VACCINE

Safety and Immunogenicity of Influenza A H5 Subunit Vaccines: Effect of Vaccine Schedule and Antigenic Variant

(2011) Robert B. Belshe et al.   JOURNAL OF INFECTIOUS DISEASES

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Inactivated Influenza Vaccines in Children

(2011) Steven Black et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Targeting TLRs Expands the Antibody Repertoire in Response to a Malaria Vaccine

(2011) S. R. Wiley et al.   Science Translational Medicine

Adjuvants that stimulate TLR3 or NLPR3 pathways enhance the efficiency of influenza virus-like particle vaccines in aged mice

(2011) Kirsten Schneider-Ohrum et al.   VACCINE

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Safety and immunogenicity of an MF59®-adjuvanted A/H5N1 pre-pandemic influenza vaccine in adults and the elderly

(2011) Timo Vesikari et al.   VACCINE

H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses

(2010) Philippe Moris et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus

(2010) Takeshi Ichinohe et al.   JOURNAL OF MEDICAL VIROLOGY

Characterization of lentiviral pseudotypes with influenza H5N1 hemagglutinin and their performance in neutralization assays

(2010) Wei Wang et al.   JOURNAL OF VIROLOGICAL METHODS

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Production of H5N1 (NIBRG-14) inactivated whole virus and split virion influenza vaccines and analysis of immunogenicity in mice using different adjuvant formulations

(2010) Cosue Miyaki et al.   VACCINE

Cross-clade protection against HPAI H5N1 influenza virus challenge in BALB/c mice intranasally administered adjuvant-combined influenza vaccine

(2010) Penghui Yang et al.   VETERINARY MICROBIOLOGY

Optimization and evaluation of an influenza A (H5) pseudotyped lentiviral particle-based serological assay

(2009) Jean-Michel Garcia et al.   JOURNAL OF CLINICAL VIROLOGY

Immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1, NIBRG-14) vaccine administered by intramuscular or subcutaneous injection

(2009) Daisuke Ikeno et al.   MICROBIOLOGY AND IMMUNOLOGY

Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans

(2008) Lance C Jennings et al.   LANCET INFECTIOUS DISEASES