Therapeutic targeting of trained immunity

TNF inhibitors in rheumatoid arthritis and spondyloarthritis: Are they the same?

(2018) Andrea Rubbert-Roth et al.   AUTOIMMUNITY REVIEWS

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

(2018) Carsten Krieg et al.   NATURE MEDICINE

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

(2018) Marnix Lameijer et al.   Nature Biomedical Engineering

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Nanoimmunotherapy to treat ischaemic heart disease

(2018) Raphaël Duivenvoorden et al.   Nature Reviews Cardiology

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance

(2018) Mounia S. Braza et al.   IMMUNITY

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes

(2017) Atsushi Anzai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

De-novo and acquired resistance to immune checkpoint targeting

(2017) Nicholas L Syn et al.   LANCET ONCOLOGY

Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification

(2017) Yi-Ching Lin et al.   MOLECULAR IMMUNOLOGY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

(2017) John A. Hamilton et al.   NATURE REVIEWS DRUG DISCOVERY

Immunogenicity and loss of response to TNF inhibitors: implications for rheumatoid arthritis treatment

(2017) Joachim R. Kalden et al.   Nature Reviews Rheumatology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway

(2017) Tania O. Crişan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Friend or Foe? The Ambiguous Role of Innate Lymphoid Cells in Cancer Development

(2017) Jochen Mattner et al.   TRENDS IN IMMUNOLOGY

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

Immune Checkpoint Therapies in Prostate Cancer

(2016) Sangeeta Goswami et al.   CANCER JOURNAL

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

A Phase II Efficacy and Safety, Open-Label, Multicenter Study of Imprime PGG Injection in Combination With Cetuximab in Patients With Stage IV KRAS-Mutant Colorectal Cancer

(2016) Neil H. Segal et al.   Clinical Colorectal Cancer

Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation

(2016) Itziar Martinez-Gonzalez et al.   IMMUNITY

Immune checkpoint inhibition in ovarian cancer

(2016) Junzo Hamanishi et al.   INTERNATIONAL IMMUNOLOGY

Cellular Innate Immunity: An Old Game with New Players

(2016) Georg Gasteiger et al.   Journal of Innate Immunity

Cellular metabolism of myeloid cells in sepsis

(2016) Rob J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

(2016) Celine Boutros et al.   Nature Reviews Clinical Oncology

Epigenetic drug discovery: breaking through the immune barrier

(2016) David F. Tough et al.   NATURE REVIEWS DRUG DISCOVERY

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Immune cell screening of a nanoparticle library improves atherosclerosis therapy

(2016) Jun Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models

(2016) Carlos Pérez-Medina et al.   JACC-Cardiovascular Imaging

Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

(2016) Yiming Zhao et al.   Nature Communications

Immunometabolic Pathways in BCG-Induced Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Reports

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages

(2016) Rob J. W. Arts et al.   OncoImmunology

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine

(2015) Ce Tang et al.   Cell Host & Microbe

The Epigenetic Memory of Monocytes and Macrophages as a Novel Drug Target in Atherosclerosis

(2015) Siroon Bekkering et al.   CLINICAL THERAPEUTICS

Atherosclerotic Vascular Disease in the Autoimmune Rheumatologic Patient

(2015) Rekha Mankad   Current Atherosclerosis Reports

PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles

(2015) C. Perez-Medina et al.   JOURNAL OF NUCLEAR MEDICINE

Innate immune memory: a paradigm shift in understanding host defense

(2015) Mihai G Netea et al.   NATURE IMMUNOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Targeting GM-CSF in inflammatory diseases

(2015) Ian P. Wicks et al.   Nature Reviews Rheumatology

Innate lymphoid cells: A new paradigm in immunology

(2015) G. Eberl et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Trained immunity in newborn infants of HBV-infected mothers

(2015) Michelle Hong et al.   Nature Communications

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

(2015) J. Tang et al.   Science Advances

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

(2014) Johanneke Kleinnijenhuis et al.   CLINICAL IMMUNOLOGY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial

(2014) Caroline Robert et al.   LANCET

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Interferon-Tau Attenuates Uptake of Nanoparticles and Secretion of Interleukin-1β in Macrophages

(2014) Kyoko Hara et al.   PLoS One

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation

(2014) Raphaël Duivenvoorden et al.   Nature Communications

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

(2013) Johanneke Kleinnijenhuis et al.   Journal of Innate Immunity

Multifunctional Gold Nanoparticles for Diagnosis and Therapy of Disease

(2013) Aneta J. Mieszawska et al.   MOLECULAR PHARMACEUTICS

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

(2013) David J. Rickard et al.   PLoS One

Reversal of Immunoparalysis in HumansIn Vivo

(2012) Jenneke Leentjens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Peptidoglycan and muramyl dipeptide from Staphylococcus aureus induce the expression of VEGF-A in human limbal fibroblasts with the participation of TLR2-NFκB and NOD2-EGFR

(2012) Marco Adán Juárez–Verdayes et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Proinflammatory cytokine signaling required for the generation of natural killer cell memory

(2012) Joseph C. Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of immune cell functions during post-septic immunosuppression

(2011) William F. Carson et al.   Epigenetics

Innate and adaptive immune responses to cell death

(2011) Kenneth L. Rock et al.   IMMUNOLOGICAL REVIEWS

Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress

(2011) Twan Lammers et al.   JOURNAL OF CONTROLLED RELEASE

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

(2011) Mark E. Lobatto et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer immunotherapy – revisited

(2011) W. Joost Lesterhuis et al.   NATURE REVIEWS DRUG DISCOVERY

Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

(2010) Daniel Cejka et al.   ARTHRITIS AND RHEUMATISM

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe

(2010) Wei Chen et al.   FASEB JOURNAL

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Imaging and quantifying the morphology of an organic–inorganic nanoparticle at the sub-nanometre level

(2010) Matti M. van Schooneveld et al.   Nature Nanotechnology

Nanotechnological strategies for engineering complex tissues

(2010) Tal Dvir et al.   Nature Nanotechnology

Nanoparticulate Assemblies of Amphiphiles and Diagnostically Active Materials for Multimodality Imaging

(2009) Willem J. M. Mulder et al.   ACCOUNTS OF CHEMICAL RESEARCH

Laminarin-mediated targeting to Dectin-1 enhances antigen-specific immune responses

(2009) Jianhui Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissecting the role of mTOR: Lessons from mTOR inhibitors

(2009) Ryan J.O. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Reactivation of rheumatoid arthritis after pregnancy: Increased phagocyte and recurring lymphocyte gene activity

(2008) Thomas Häupl et al.   ARTHRITIS AND RHEUMATISM

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES