Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants
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Title
Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 291, Issue 3, Pages 1123-1136
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2015-11-11
DOI
10.1074/jbc.m115.683011
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Note: Only part of the references are listed.- Mechanisms and Functions of Inflammasomes
- (2014) Mohamed Lamkanfi et al. CELL
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- (2014) Ewa Oleszycka et al. CURRENT OPINION IN IMMUNOLOGY
- Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants
- (2014) Silke Neumann et al. IMMUNOLOGY AND CELL BIOLOGY
- Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome
- (2014) M. Kool et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3
- (2014) H. Li et al. JOURNAL OF IMMUNOLOGY
- Inflammasome-Dependent and -Independent IL-18 Production Mediates Immunity to the ISCOMATRIX Adjuvant
- (2014) N. S. Wilson et al. JOURNAL OF IMMUNOLOGY
- Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells
- (2014) Arnaud M. Didierlaurent et al. JOURNAL OF IMMUNOLOGY
- Development of a minimal saponin vaccine adjuvant based on QS-21
- (2014) Alberto Fernández-Tejada et al. Nature Chemistry
- Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
- (2014) D. Weng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime–protein boost HIV-1 vaccine
- (2014) Kimberly Pouliot et al. VACCINE
- Reduced MyD88 dependency of ISCOMATRIX™ adjuvant in a DNA prime-protein boost HIV vaccine
- (2014) Rachel Buglione-Corbett et al. Human Vaccines & Immunotherapeutics
- Matrix-M™ adjuvant: enhancing immune responses by ‘setting the stage’ for the antigen
- (2013) Karin Lövgren Bengtsson et al. Expert Review of Vaccines
- Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data
- (2013) Philip Bejon et al. LANCET INFECTIOUS DISEASES
- Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure
- (2013) Ally Olotu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Serum Cytokine Profiles Associated with Specific Adjuvants Used in a DNA Prime-Protein Boost Vaccination Strategy
- (2013) Rachel Buglione-Corbett et al. PLoS One
- Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells
- (2013) A. S. McKee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immune enhancing properties of the novel Matrix-M™ adjuvant leads to potentiated immune responses to an influenza vaccine in mice
- (2013) Sofia E. Magnusson et al. VACCINE
- Licensing Adaptive Immunity by NOD-Like Receptors
- (2013) Dong Liu et al. Frontiers in Immunology
- The NLRP12 Inflammasome Recognizes Yersinia pestis
- (2012) Gregory I. Vladimer et al. IMMUNITY
- ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases
- (2012) A. Baz Morelli et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes
- (2012) Eric K. Chea et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
- (2012) NEW ENGLAND JOURNAL OF MEDICINE
- GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals
- (2012) A. R. Shenoy et al. SCIENCE
- The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
- (2011) Beckley K. Davis et al. Annual Review of Immunology
- Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci
- (2011) Lee M. Krug et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer
- (2011) Govind Ragupathi et al. Expert Review of Vaccines
- ISCOM technology-based Matrix M™ adjuvant: success in future vaccines relies on formulation
- (2011) Karin Lövgren Bengtsson et al. Expert Review of Vaccines
- Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems
- (2011) Nathalie Garçon et al. Expert Review of Vaccines
- Regulation of the Antimicrobial Response by NLR Proteins
- (2011) Eran Elinav et al. IMMUNITY
- ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells
- (2011) P. Duewell et al. JOURNAL OF IMMUNOLOGY
- RIP3 mediates the embryonic lethality of caspase-8-deficient mice
- (2011) William J. Kaiser et al. NATURE
- First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children
- (2011) NEW ENGLAND JOURNAL OF MEDICINE
- The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants
- (2010) Roberto Spreafico et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- ISCOMATRIX™ vaccines: Safety in human clinical studies
- (2010) Andrew McKenzie et al. Human vaccines & immunotherapeutics
- Regulation of adaptive immunity by the NLRP3 inflammasome
- (2010) Mingkuan Chen et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Regulation of Adaptive Immunity by the Innate Immune System
- (2010) A. Iwasaki et al. SCIENCE
- Mechanism of action of clinically approved adjuvants
- (2009) Bart N Lambrecht et al. CURRENT OPINION IN IMMUNOLOGY
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity
- (2009) A. S. McKee et al. JOURNAL OF IMMUNOLOGY
- AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity
- (2009) A. M. Didierlaurent et al. JOURNAL OF IMMUNOLOGY
- Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
- (2009) Fiona A. Sharp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ISCOMs and ISCOMATRIX™
- (2009) Hong-Xiang Sun et al. VACCINE
- The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity
- (2008) Luigi Franchi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
- (2008) Stephanie C. Eisenbarth et al. NATURE
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
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- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
- (2008) C. Dostert et al. SCIENCE
- The safety and tolerability of an HIV-1 DNA prime–protein boost vaccine (DP6-001) in healthy adult volunteers
- (2008) Jeffrey S. Kennedy et al. VACCINE
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