C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets

Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors

(2017) Jenny Ostrop et al.   JOURNAL OF IMMUNOLOGY

C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice

(2017) T. Shirai et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

(2017) Donnele Daley et al.   NATURE MEDICINE

Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate

(2017) Alexey V. Kostarnoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

(2017) Anthony Troegeler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity

(2017) Masahiro Nagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation

(2017) Can Li et al.   Scientific Reports

Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity

(2017) Mika K. Kaneko et al.   Cancer Medicine

Development and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN

(2017) Mika K. Kaneko et al.   Cancer Medicine

C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells

(2017) Daiki Mori et al.   PLoS One

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

(2016) Emmanuel C Patin et al.   Innate Immunity

Vaccine adjuvants as potential cancer immunotherapeutics

(2016) Burcu Temizoz et al.   INTERNATIONAL IMMUNOLOGY

An atypical role for the myeloid receptor Mincle in central nervous system injury

(2016) Thiruma V Arumugam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization

(2016) Simon D. van Haren et al.   JOURNAL OF IMMUNOLOGY

Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye

(2016) Ellen J. Lee et al.   JOURNAL OF IMMUNOLOGY

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis

(2016) Yoshitaka Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity

(2016) Tomofumi Uto et al.   Nature Communications

Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells

(2016) Yinghua Zhao et al.   Nature Communications

A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy

(2016) Zhongyi Yan et al.   Oncotarget

The lectin-like oxidized LDL receptor-1: a new potential molecular target in colorectal cancer

(2016) Michela Murdocca et al.   Oncotarget

Stat6-Dependent Inhibition of Mincle Expression in Mouse and Human Antigen-Presenting Cells by the Th2 Cytokine IL-4

(2016) Thomas Hupfer et al.   Frontiers in Immunology

MICL controls inflammation in rheumatoid arthritis

(2015) Pierre Redelinghuys et al.   ANNALS OF THE RHEUMATIC DISEASES

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor

(2015) Akimasa SENO et al.   EXPERIMENTAL ANIMALS

Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses

(2015) Ryoko Kiyotake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2

(2015) Sabine A. F. Jégouzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of MINCLE–SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB

(2015) Jenny Ostrop et al.   JOURNAL OF IMMUNOLOGY

C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation

(2015) Yasunobu Miyake et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype

(2015) Min Liu et al.   JOURNAL OF IMMUNOLOGY

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

(2015) Yao-Wen Chang et al.   Oncotarget

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

(2015) Lena Seifert et al.   Cell Reports

The Consequences of Multiple Simultaneous C-Type Lectin–Ligand Interactions: DCIR Alters the Endo-Lysosomal Routing of DC-SIGN

(2015) Juan J. García-Vallejo et al.   Frontiers in Immunology

Targeting C-Type Lectin Receptors for Cancer Immunity

(2015) Huimin Yan et al.   Frontiers in Immunology

CLEC-2 is required for development and maintenance of lymph nodes

(2014) C. Benezech et al.   BLOOD

Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity

(2014) Brigitte A. Wevers et al.   Cell Host & Microbe

C-Type Lectin-like Receptor LOX-1 Promotes Dendritic Cell-Mediated Class-Switched B Cell Responses

(2014) HyeMee Joo et al.   IMMUNITY

Bone marrow-derived macrophages from BALB/c and C57BL/6 mice fundamentally differ in their respiratory chain complex proteins, lysosomal enzymes and components of antioxidant stress systems

(2014) Maren Depke et al.   Journal of Proteomics

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

(2014) Sophie E. Acton et al.   NATURE

Role of the C-Type Lectin Receptors MCL and DCIR in Experimental Colitis

(2014) Julia Hütter et al.   PLoS One

Lectin-Like Oxidized LDL Receptor-1 Is an Enhancer of Tumor Angiogenesis in Human Prostate Cancer Cells

(2014) Iván González-Chavarría et al.   PLoS One

A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin

(2014) Yukinari Kato et al.   Scientific Reports

Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

(2014) Shiho Chiba et al.   eLife

Computational and Experimental Prediction of Human C-Type Lectin Receptor Druggability

(2014) Jonas Aretz et al.   Frontiers in Immunology

Role of Bacterial Lipopolysaccharide in Enhancing Host Immune Response toCandida albicans

(2013) Helen Rogers et al.   Clinical & Developmental Immunology

β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells

(2013) Jie Tian et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ

(2013) Ana Lobato-Pascual et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Dectin-2 family of C-type lectin-like receptors: an update

(2013) Bernhard Kerscher et al.   INTERNATIONAL IMMUNOLOGY

Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells

(2013) Amir H. Massoud et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity

(2013) Kenneth K.C. Bramwell et al.   JOURNAL OF CLINICAL INVESTIGATION

Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

(2013) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

Platelets Promote Tumor Growth and Metastasis via Direct Interaction between Aggrus/Podoplanin and CLEC-2

(2013) Satoshi Takagi et al.   PLoS One

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke

(2013) Yukiya Suzuki et al.   Scientific Reports

The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells

(2012) G. Schreibelt et al.   BLOOD

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

(2012) Sophie E. Acton et al.   IMMUNITY

F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

(2012) Susan Ahrens et al.   IMMUNITY

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

(2012) Jian-Guo Zhang et al.   IMMUNITY

Oral administration of soluble β-glucans extracted fromGrifola frondosainduces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice

(2012) Yuki Masuda et al.   INTERNATIONAL JOURNAL OF CANCER

Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas

(2012) Juan P Rodrigo et al.   Molecular Cancer

Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

(2012) I. D. Iliev et al.   SCIENCE

Platelet CLEC-2 and podoplanin in cancer metastasis

(2012) Kate L. Lowe et al.   THROMBOSIS RESEARCH

DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway

(2011) A. A. Lambert et al.   BLOOD

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

(2011) Diego Mourão-Sá et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: Findings, implications and open questions

(2011) Roland Lang et al.   IMMUNOBIOLOGY

Human C-type Lectin Domain Family 4, Member C (CLEC4C/BDCA-2/CD303) Is a Receptor for Asialo-galactosyl-oligosaccharides

(2011) Elena Riboldi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel platelet activation receptor CLEC-2: from discovery to prospects

(2011) K. SUZUKI-INOUE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Human C-Type Lectin-Like Receptor CLEC-1 is Upregulated by TGF-β and Primarily Localized in the Endoplasmic Membrane Compartment

(2011) S. Sattler et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

(2010) J. Chang et al.   BLOOD

Orally Administered Particulate  -Glucan Modulates Tumor-Capturing Dendritic Cells and Improves Antitumor T-Cell Responses in Cancer

(2010) B. Li et al.   CLINICAL CANCER RESEARCH

The complete inventory of receptors encoded by the rat natural killer cell gene complex

(2010) Line M. Flornes et al.   IMMUNOGENETICS

Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome)

(2009) Shunji Tomatsu et al.   HUMAN MUTATION

Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells

(2009) Elena Riboldi et al.   IMMUNOBIOLOGY

Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis

(2009) Juan J. García-Vallejo et al.   IMMUNOLOGICAL REVIEWS

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

(2009) Matthew J. Robinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The C-Type Lectin-Like Receptor CLEC-1, Expressed by Myeloid Cells and Endothelial Cells, Is Up-Regulated by Immunoregulatory Mediators and Moderates T Cell Activation

(2009) P. Thebault et al.   JOURNAL OF IMMUNOLOGY

Effect of Yeast-derived β-glucan in Conjunction With Bevacizumab for the Treatment of Human Lung Adenocarcinoma in Subcutaneous and Orthotopic Xenograft Models

(2009) Wangjian Zhong et al.   JOURNAL OF IMMUNOTHERAPY

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Renal cells activate the platelet receptor CLEC-2 through podoplanin

(2008) Charita M. Christou et al.   BIOCHEMICAL JOURNAL

Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand

(2008) Elwira Pyż et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

(2008) Cristal Huysamen et al.   FEMS MICROBIOLOGY LETTERS

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION

DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production

(2008) Friederike Meyer-Wentrup et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells

(2008) Noriyuki Fujikado et al.   NATURE MEDICINE