3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates

Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity

(2020) Sebastian Ols et al.   Cell Reports

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

(2019) Andrew T. Jones et al.   Nature Communications

T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells

(2019) Sara L. Stone et al.   IMMUNITY

IFNγ induces epigenetic programming of human T-bethi B cells and promotesTLR7/8 and IL-21 induced differentiation

(2019) Esther Zumaquero et al.   eLife

Innate sensors that regulate vaccine responses

(2019) Philipp Georg et al.   CURRENT OPINION IN IMMUNOLOGY

Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses

(2018) Emilie Seydoux et al.   JOURNAL OF IMMUNOLOGY

HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees

(2018) Nicole L. Yates et al.   JOURNAL OF VIROLOGY

Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant

(2018) Yingxia Wen et al.   PLoS One

Vaccines We Need But Don't Have

(2018) Stanley A. Plotkin   VIRAL IMMUNOLOGY

Long-Lived Plasma Cells in Mice and Men

(2018) Siggeir F. Brynjolfsson et al.   Frontiers in Immunology

HPV vaccines – A review of the first decade

(2017) Diane M. Harper et al.   GYNECOLOGIC ONCOLOGY

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial

(2017) Supachai Rerks-Ngarm et al.   JOURNAL OF INFECTIOUS DISEASES

A critical appraisal of ‘Shingrix’, a novel herpes zoster subunit vaccine (HZ/Su or GSK1437173A) for varicella zoster virus

(2017) Tehmina Bharucha et al.   Human Vaccines & Immunotherapeutics

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

(2017) Margherita Coccia et al.   npj Vaccines

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

(2016) Christopher B. Fox et al.   JOURNAL OF CONTROLLED RELEASE

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

(2016) Sudhir Pai Kasturi et al.   JOURNAL OF VIROLOGY

TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes

(2016) Paul F. McKay et al.   PLoS One

CXCL13 is a plasma biomarker of germinal center activity

(2016) Colin Havenar-Daughton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

(2016) Colin Havenar-Daughton et al.   Cell Reports

Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection

(2015) Jerome H. Kim et al.   Annual Review of Medicine

Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow

(2015) Jessica L. Halliley et al.   IMMUNITY

Dengue Virus Infection Induces Expansion of a CD14+CD16+ Monocyte Population that Stimulates Plasmablast Differentiation

(2014) Marcin Kwissa et al.   Cell Host & Microbe

Progress in HIV-1 vaccine development

(2014) Barton F. Haynes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials

(2014) Anna Sambor et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Diminished Viral Control during Simian Immunodeficiency Virus Infection Is Associated with Aberrant PD-1hiCD4 T Cell Enrichment in the Lymphoid Follicles of the Rectal Mucosa

(2014) Geetha H. Mylvaganam et al.   JOURNAL OF IMMUNOLOGY

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

Activated CD4+CCR5+T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques

(2014) Diane G. Carnathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7

(2014) Christopher B Fox et al.   JOURNAL OF NANOBIOTECHNOLOGY

Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

(2013) Dan H. Barouch et al.   CELL

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

(2013) Hua-Xin Liao et al.   IMMUNITY

Immunity to viruses: learning from successful human vaccines

(2013) Bali Pulendran et al.   IMMUNOLOGICAL REVIEWS

Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen

(2013) Heather E. Lynch et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Antigenicity and Immunogenicity of Transmitted/Founder, Consensus, and Chronic Envelope Glycoproteins of Human Immunodeficiency Virus Type 1

(2013) H.-X. Liao et al.   JOURNAL OF VIROLOGY

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

(2013) Katija Jelicic et al.   NATURE IMMUNOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

(2012) M. Kwissa et al.   BLOOD

Non-neutralizing antibodies in prevention of HIV infection

(2012) Harriet L. Robinson   EXPERT OPINION ON BIOLOGICAL THERAPY

Cervarix®: a bivalent vaccine against HPV types 16 and 18, with cross-protection against other high-risk HPV types

(2012) Anne Szarewski   Expert Review of Vaccines

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses

(2011) Justin Pollara et al.   CYTOMETRY PART A

The long-term potential of biodegradable poly(lactideco-glycolide) microparticles as the next-generation vaccine adjuvant

(2011) Siddhartha Jain et al.   Expert Review of Vaccines

Prevention of Infection by a Granulocyte-Macrophage Colony-Stimulating Factor Co-Expressing DNA/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine

(2011) Lilin Lai et al.   JOURNAL OF INFECTIOUS DISEASES

Aluminum Adjuvant Dose Guidelines in Vaccine Formulation for Preclinical Evaluations

(2011) Simone Vecchi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Mechanisms that determine plasma cell lifespan and the duration of humoral immunity

(2010) Ian J. Amanna et al.   IMMUNOLOGICAL REVIEWS

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

(2009) Kenneth Smith et al.   Nature Protocols

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Simultaneous Evaluation of the Magnitude and Breadth of a Left- and Right-Censored Multivariate Response, With Application to HIV Vaccine Development

(2009) Yunda Huang et al.   Statistics in Biopharmaceutical Research

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE