Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Germ‐free and microbiota‐associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes

(2020) Annika Hausmann et al.   CELLULAR MICROBIOLOGY

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

(2020) Annika Hausmann et al.   Mucosal Immunology

Salmonella enterica infection of murine and human enteroid-derived monolayers elicits differential activation of epithelial-intrinsic inflammasomes

(2020) Mayumi K. Holly et al.   INFECTION AND IMMUNITY

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes

(2020) Shauna M. Crowley et al.   PLoS Pathogens

Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18

(2020) Namrata Iyer et al.   PLoS Pathogens

Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium

(2020) Stefan A. Fattinger et al.   PLoS Pathogens

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

(2020) Balázs Koscsó et al.   Science Immunology

Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

(2020) Sampsa Matikainen et al.   JOURNAL OF IMMUNOLOGY

NAIP-NLRC4-deficient mice are susceptible to shigellosis

(2020) Patrick S Mitchell et al.   eLife

Epithelial inflammasomes in the defense against Salmonella gut infection

(2020) Stefan A Fattinger et al.   CURRENT OPINION IN MICROBIOLOGY

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

(2019) Renée R.C.E. Schreurs et al.   IMMUNITY

Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases

(2019) Barbara Ruder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

(2019) Markus Furter et al.   Cell Reports

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

Canonical and noncanonical inflammasomes in intestinal epithelial cells

(2019) Nathaniel Winsor et al.   CELLULAR MICROBIOLOGY

Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection

(2019) Trung H.M. Pham et al.   Cell Host & Microbe

Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

(2018) Johanna Pott et al.   Cell Host & Microbe

A Nonpyroptotic IFN-γ–Triggered Cell Death Mechanism in Nonphagocytic Cells PromotesSalmonellaClearance In Vivo

(2018) Justin P. Ingram et al.   JOURNAL OF IMMUNOLOGY

Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens

(2018) Mikael E. Sellin et al.   JOURNAL OF MOLECULAR BIOLOGY

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo

(2018) Kaiyi Zhang et al.   PLoS Pathogens

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

(2018) Mark Schmitt et al.   Cell Reports

The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses

(2018) Damien Bierschenk et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor–Mediated Destruction of Intestinal Epithelial Cells

(2017) Thomas Grabinger et al.   GASTROENTEROLOGY

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

High-avidity IgA protects the intestine by enchaining growing bacteria

(2017) Kathrin Moor et al.   NATURE

Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome

(2017) Valeria M. Reyes Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organoid-based epithelial to mesenchymal transition (OEMT) model: from an intestinal fibrosis perspective

(2017) Soojung Hahn et al.   Scientific Reports

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

Deciphering the Complex Signaling Systems That Regulate Intestinal Epithelial Cell Death Processes and Shedding

(2017) Angela M. Patterson et al.   Frontiers in Immunology

IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection

(2016) Tamas Dolowschiak et al.   Cell Host & Microbe

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease

(2016) Alon D. Levin et al.   Journal of Crohns & Colitis

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo

(2016) Isabella Rauch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 recruitment by NLRC4 duringSalmonellainfection

(2016) Yan Qu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice

(2016) Yue Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection

(2016) Anna A. Müller et al.   PLoS Pathogens

Epithelial NAIPs protect against colonic tumorigenesis

(2015) Ramanjaneyulu Allam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

Inflammasomes of the intestinal epithelium

(2015) Mikael E. Sellin et al.   TRENDS IN IMMUNOLOGY

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Pleiotropic functions of TNF-  in the regulation of the intestinal epithelial response to inflammation

(2014) M. Leppkes et al.   INTERNATIONAL IMMUNOLOGY

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

(2014) T Grabinger et al.   Cell Death & Disease

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis

(2014) Lisa Maier et al.   PLoS Pathogens

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

(2013) Anna Ermund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

(2013) S Nordlander et al.   Mucosal Immunology

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

Innate Immune Detection of Flagellin Positively and Negatively Regulates Salmonella Infection

(2013) Marvin A. Lai et al.   PLoS One

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella Gut Invasion Involves TTSS-2-Dependent Epithelial Traversal, Basolateral Exit, and Uptake by Epithelium-Sampling Lamina Propria Phagocytes

(2012) Andreas J. Müller et al.   Cell Host & Microbe

Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

(2012) F A Carvalho et al.   Mucosal Immunology

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Intestinal antimicrobial peptides during homeostasis, infection, and disease

(2012) Luciana R. Muniz et al.   Frontiers in Immunology

The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut

(2011) Stefan Koch et al.   Annual Review of Pathology-Mechanisms of Disease

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection

(2011) Pascal Songhet et al.   PLoS One

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

(2010) Porfirio Nava et al.   IMMUNITY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Dissemination of invasiveSalmonellavia bacterial-induced extrusion of mucosal epithelia

(2010) Leigh A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation

(2009) Andreas J. Müller et al.   Cell Host & Microbe

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Motility allows S. Typhimurium to benefit from the mucosal defence

(2008) Bärbel Stecher et al.   CELLULAR MICROBIOLOGY

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA