Review
Medicine, General & Internal
Chao Li, Wei Wang, Shuai-shuai Xie, Wen-xian Ma, Qian-wen Fan, Ying Chen, Yuan He, Jia-nan Wang, Qin Yang, Hai-di Li, Juan Jin, Ming-ming Liu, Xiao-ming Meng, Jia-gen Wen
Summary: Sepsis-induced acute kidney injury (AKI) is a severe complication that involves multiple types of cells such as macrophages, ECs, and TECs, with programmed cell death playing a significant role. Mitochondrial dysfunction and oxidative stress are traditionally considered as the main triggers, while recent research highlights the involvement of autophagy, mitochondria quality control, and epigenetic modification in the process of programmed cell death.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Aleksei Parshenkov, Thierry Hennet
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Yanqiang Shi, Fachao Zhi
Summary: IRF1 deficiency maintains intestinal barrier integrity by restricting TNF alpha-induced IEC shedding.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Immunology
Wen Xu, Yi Huang
Summary: Cell death is a necessary event to maintain homeostasis in multicellular organisms. Different forms of cell death trigger inflammatory responses and are associated with various human inflammatory diseases. Recent studies suggest that phosphorylation plays a critical role in inflammatory cell death regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Matthias Kist, Domagoj Vucic
Summary: In recent years, research has identified various forms of cell death, each relying on different proteins for activation. Many pathways share components and signaling principles, working together rather than independently. Several cell death regulators are linked to human diseases and may be potential therapeutic targets.
Review
Immunology
Chunxia Shi, Pan Cao, Yukun Wang, Qingqi Zhang, Danmei Zhang, Yao Wang, Luwen Wang, Zuojiong Gong
Summary: PANoptosis is a newly proposed cell death characterized by the combination of pyroptosis, apoptosis and necroptosis. This review focuses on the relationship between these three modes of cell death, the key molecules involved, the formation of PANoptosome, and the role of PANoptosis in diseases. The aim is to understand the mechanism of PANoptosis and provide a basis for targeted intervention in treating PANoptosis-related diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Damien Bertheloot, Eicke Latz, Bernardo S. Franklin
Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Oncology
Yingying Wu, Xiaoling Wen, Yufang Xia, Xiao Yu, Yanhui Lou
Summary: Regulated Cell Death (RCD) is a mode of cell death that occurs through drug or genetic intervention, and the regulation of RCDs is a significant factor in tumor cell survival and patient prognosis. Long non-coding RNAs (lncRNAs) play a role in regulating tumor biological processes, including RCDs on tumor cells, and are closely related to tumor progression. This review describes the mechanisms of eight different RCDs and their roles in tumors, while also outlining the regulatory relationships between lncRNAs and RCDs in tumor cells, aiming to provide new insights for tumor diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Haiyue Tu, Haoyu Ren, Junjie Jiang, Changshun Shao, Yufang Shi, Peishan Li
Summary: This review discusses the multifarious neutrophil death pathways and their effects on immune responses and disease progression. Understanding the multifaceted aspects of neutrophil death and the ramifications of immunity is crucial for the development of novel therapeutic methods.
Article
Multidisciplinary Sciences
Lingling Zhuang, Qiran Sun, Shenglan Huang, Lanyan Hu, Qi Chen
Summary: PANoptosis is involved in tumorigenesis and is associated with immune and inflammatory responses, serving as a predictive indicator of tumor prognosis and immunotherapy response.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Wenchang Yang, Kaixiong Tao, Yaxin Wang, Yongzhou Huang, Caihan Duan, Tao Wang, Chengguo Li, Peng Zhang, Yuping Yin, Jinbo Gao, Ruidong Li
Summary: Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract with insufficient therapeutic efficacy. Recent research has shown that necrosulfonamide (NSA) can protect against various inflammatory diseases by blocking the polymerization of mixed lineage kinase domain-like protein (MLKL). This study demonstrates that NSA can alleviate symptoms of dextran sodium sulfate (DSS)-induced colitis in mouse models by reducing weight loss and disease activity. NSA also inhibits the accumulation of macrophages and CD4+/CD8+ T-cells in the colon tissue caused by DSS. Mechanistically, NSA inhibits pyroptosis and necroptosis pathways by reducing the expression of phosphorylated MLKL and N-gasdermin D (N-GSDMD).
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dongming Guo, Xinlei Huang, Tianqing Xiong, Xingyi Wang, Jingwen Zhang, Yingge Wang, Jingyan Liang
Summary: Methamphetamine, commonly known as METH, is a highly addictive drug that can lead to addiction and various health issues. This review discusses the molecular mechanisms of neuronal damage caused by METH and identifies potential therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Mingxia Jiang, Ling Qi, Lisha Li, Yiming Wu, Dongfeng Song, Yanjing Li
Summary: Caspase-8 is a key player in cancer, involved in multiple programmed cell death modes and closely associated with tumor growth, invasion, therapeutic resistance, etc.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Cell Biology
Ashleigh N. Riegler, Paul Benson, Kenneth Long, Sixto M. Leal Jr
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to increased pyroptosis and necroptosis in lung tissues, while apoptosis and ferroptosis show no significant changes. The increase in pyroptosis appears to be driven by inflammation, while necroptosis is strongly correlated with viral burden. These findings suggest a novel mechanism for viral-mediated necroptosis and highlight the potential role of lytic programmed cell death pathways in mediating infection outcome.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Shiyi Chen, Jiacheng Jiang, Tongfu Li, Longshuang Huang
Summary: PANoptosis is a newly defined form of programmed cell death that can involve pyroptosis, apoptosis, and necroptosis. Excessive cell death can lead to inflammation and tissue damage, which are associated with acute lung injury and chronic obstructive pulmonary disease exacerbation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)