Article
Multidisciplinary Sciences
Yundan Wang, Xiwen Tong, Shenglei Yuan, Pengcheng Yang, Ling Li, Yong Zhao, Le Kang
Summary: Changes in population density affect the phenotypic differentiation and immune strategies of solitary and gregarious locusts, with gregarious locusts showing reduced phagocytosis and altered gene expression related to immunity. The expression of cytokine TNF plays a key role in regulating the immune response of locusts, with different effects on solitary and gregarious locusts, ultimately impacting their survival after fungal infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Gastroenterology & Hepatology
Huiying Lu, Cui Zhang, Wei Wu, Huimin Chen, Ritian Lin, Ruicong Sun, Xiang Gao, Gengfeng Li, Qiong He, Han Gao, Xiaohan Wu, Jian Lin, Ruixin Zhu, Jianli Niu, Pappachan E. Kolattukudy, Zhanju Liu
Summary: This study investigated the roles of MCPIP1 in modulating the differentiation and functions of intestinal macrophages in the pathogenesis of IBD. It was found that MCPIP1 deficiency exacerbated intestinal inflammation.
Review
Immunology
Emmanuel Treiner
Summary: Non-classical HLA restricted T cell subsets, such as gamma delta T and NK-T cells, have potential for immune-based therapy in hematological malignancies. Mucosal-Associated Invariant T cells (MAIT) are innate-like T cell subsets that recognize bacterial/fungal metabolites, and their anti-tumor functions make them potential targets for therapy. However, the role of MAIT cells in solid cancers is unclear, and few studies have focused on MAIT cells in blood cancers. This review summarizes current knowledge on MAIT cells in hematological neoplasms and discusses potential approaches and limitations for using MAIT cells in novel therapies for blood cancers.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Shahram Solaymani-Mohammadi
Summary: Human giardiasis is a common parasitic disease that can lead to malnutrition and developmental disorders. Understanding the interaction between the parasite and the intestinal epithelial cells may provide insights into the pathology and help identify new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chao Liu, Wei Liu, Yanhong Liu, Hongxia Duan, Liqing Chen, Xintong Zhang, Mingji Jin, Minhu Cui, Xiuquan Quan, Libin Pan, Jiachun Hu, Zhonggao Gao, Yan Wang, Wei Huang
Summary: A high-density PEGylation-based glycocholic acid-decorated micelle (PTX@GNPs) was constructed to overcome the obstacles in the gastrointestinal environment. This micelle possesses mucus trapping escape ability and excellent intestine epithelium targeting, enhancing the oral bioavailability of paclitaxel (PTX) and exhibiting similar antitumor efficacy compared to intravenous injection. Furthermore, it can increase in vivo retention time of PTX and remodel the immune microenvironment, enhancing oral chemotherapy efficacy.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Food Science & Technology
Lianghui Cheng, Chunli Kong, Wenjia Wang, Andre Groeneveld, Arjen Nauta, Matthew R. Groves, Mensiena B. G. Kiewiet, Paul de Vos
Summary: Specific types of hMOs can attenuate TNF-alpha induced inflammation in fetal gut epithelial cells through TNFR1 in a structure-dependent fashion, suggesting the potential application of hMOs in the management of TNF-alpha dependent diseases.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Engineering, Biomedical
Elisa Boehm, Linda Droessler, Salah Amasheh
Summary: CBD, as a component of Cannabis-based biomaterials, has a strengthening effect on the cellular barrier under inflammatory conditions and mitigates the disruption of paracellular permeability and sealing proteins. These findings demonstrate the potential of CBD in therapeutic approaches against inflammatory pathogenesis.
MATERIALS TODAY BIO
(2023)
Review
Cell Biology
Friederike Uhlig, Niall P. Hyland
Summary: This review provides an overview of quorum sensing in the gut and summarizes the role of quorum sensing molecules from commensal, probiotic, and pathogenic bacteria in intestinal health and disease. It highlights the importance of further investigation into the mechanisms of action of quorum sensing at the intestinal neuro-immune interface.
Article
Gastroenterology & Hepatology
Jessica A. Breznik, Jennifer Jury, Elena F. Verdu, Deborah M. Sloboda, Dawn M. E. Bowdish
Summary: The study found that diet-induced obesity in female mice has tissue- and time-dependent effects on intestinal paracellular permeability as well as monocyte-derived and tissue-resident macrophage numbers, surface marker phenotype, and intracellular production of the cytokines IL-10 and TNF. These changes were not mediated by TNF.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Review
Immunology
Guanglin Cui, Jon Florholmen, Rasmus Goll
Summary: Anti-TNF biological therapy is a standard treatment option for patients with inflammatory bowel disease (IBD) who do not respond to steroids or immunomodulators. However, the response rates to anti-TNF bioagents in IBD patients are often high. Mucosal TNF can be used as a biomarker to improve the precision of anti-TNF biological therapy strategies in patients with ulcerative colitis (UC), including early identification of candidates who will benefit from treatment, assessment of response and mucosal healing, as well as prediction of discontinuation of therapy and relapse after drug withdrawal. However, challenges and limitations still exist in using mucosal TNF as a biomarker in individualized anti-TNF biological therapy and further investigation is needed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jacob M. Allen, Amy R. Mackos, Robert M. Jaggers, Patricia C. Brewster, Mikaela Webb, Chia-Hao Lin, Chris Ladaika, Ronald Davies, Peter White, Brett R. Loman, Michael T. Bailey
Summary: Psychological stress alters the gut microbiota and increases the risk for enteric infections and chronic bowel conditions. Stress disrupts colonic epithelial cells and mucosal integrity, leading to dysbiosis in the gut microbiota.
Article
Biochemistry & Molecular Biology
Jinchao Li, Ying Tang, Ting-Chun Lin, Huawei Zeng, Joel B. Mason, Zhenhua Liu
Summary: Strong evidence suggests an association between body fatness and the development of colorectal cancer (CRC), but there is still limited understanding of the causality between obesity and CRC. This study investigates the role of TNF-alpha in obesity-associated CRC development. The research shows that the deletion of TNF-alpha reduces inflammation and Wnt signaling, thereby attenuating obesity-induced intestinal tumorigenesis. Targeting TNF-alpha signaling may be a potential strategy for reducing the risk of CRC associated with obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Oncology
Hong Wu, Qingxia You, Yi Jiang, Fangxiang Mu
Summary: Recurrent spontaneous abortion (RSA) is a pregnancy disorder potentially caused by immune dysfunction, with TNF-α imbalance being a key risk factor. TNF inhibitors have shown effectiveness in treating RSA by reducing immune rejection rate and improving pregnancy outcomes.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Helene Kolstad Skovdahl, Shreya Gopalakrishnan, Tarjei Dahl Svendsen, Atle van Beelen Granlund, Ingunn Bakke, Zekarias G. Ginbot, Silje Thorsvik, Arnar Flatberg, Bjornar Sporsheim, Jenny Ostrop, Tom Eirik Mollnes, Arne Kristian Sandvik, Torunn Bruland
Summary: Treatment of inflammatory bowel disease (IBD) is challenging due to the limited efficacy of available drugs, highlighting the need for biomarkers and assays to predict drug effect. The intestinal epithelium plays a crucial role in disease pathogenesis and offers a promising target for IBD treatments. Lowering oxygen concentration can better mimic the in vivo physiological environment of colonic epithelial cells and enhance the translational value of intestinal organoids in drug testing.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Shawn Goyal, Derek K. L. Tsang, Charles Maisonneuve, Stephen E. Girardin
Summary: This review highlights the influence of intestinal microbiota on host intestinal epithelial cells, focusing on the roles of microbial-derived products and how they regulate the dynamics of intestinal epithelial populations and barrier function.
MICROBES AND INFECTION
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Margot Crucet, Branko Simic, Simon Kraler, Nicole R. Bonetti, Caroline Ospelt, Oliver Distler, Adrian Ciurea, Luca Liberale, Matti Jauhiainen, Jari Metso, Melroy Miranda, Rose Cydecian, Lena Schwarz, Vera Fehr, Rita Zilinyi, Mohammad Amrollahi-Sharifabadi, Lydia Ntari, Niki Karagianni, Frank Ruschitzka, Reijo Laaksonen, Paul M. Vanhoutte, George Kollias, Giovanni G. Camici, Thomas F. Luescher
Summary: This study aimed to identify the molecular mechanism of endothelial dysfunction in a mouse model of rheumatoid arthritis (RA) and in patients with RA. The results showed that increased TNF alpha levels contribute to RA and endothelial dysfunction by increasing vascular oxLDL content and activation of the LOX-1/NF kappa B/Arg2 pathway, resulting in reduced NO bioavailability and decreased cGMP levels. Anti-TNF alpha treatment improved both articular symptoms and endothelial function by reducing LOX-1, vascular oxLDL, and Arg2 levels.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maria-Theodora Melissari, Ana Henriques, Christos Tzaferis, Alejandro Prados, Michalis E. Sarris, Niki Chalkidi, Dimitra Mavroeidi, Panagiotis Chouvardas, Sofia Grammenoudi, George Kollias, Vasiliki Koliaraki
Summary: This study investigates the various subsets of intestinal mesenchymal cells and their roles in intestinal morphogenesis and pathophysiology. The results show that Col6a1(Cre) mouse targets fibroblast subsets and perivascular cells, as well as mesenchymal aggregates crucial for intestinal development. In adulthood, Col6a1(+)/CD201(+) mesenchymal cells regulate enteroendocrine cell differentiation and epithelial proliferation. During acute colitis, they exhibit an inflammatory and extracellular matrix remodelling gene signature. However, these cells are dispensable for normal organ architecture in both homeostasis and tissue regeneration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Moritz Leppkes, Aylin Lindemann, Stefanie Goesswein, Susanne Paulus, Dominik Roth, Anne Hartung, Eva Liebing, Sebastian Zundler, Miguel Gonzalez-Acera, Jay Patankar, Fabrizio Mascia, Kristina Scheibe, Markus Hoffmann, Stefan Uderhardt, Christine Schauer, Sebastian Foersch, Clemens Neufert, Michael Vieth, Georg Schett, Raja Atreya, Anja A. Kuehl, Andre Bleich, Christoph Becker, Martin Herrmann, Markus F. Neurath
Summary: Bleeding ulcers and erosions are common in active ulcerative colitis, with fibrin layers correlated with rectal bleeding. Neutrophils induce secondary immunothrombosis through PAD4-dependent mechanisms, protecting against acute colitis and rectal bleeding. Deficiency in immunothrombosis can lead to exacerbated colitis and increased bleeding.
Article
Oncology
Antonia M. Stehr, Guangxia Wang, Richard Demmler, Marc P. Stemmler, Julia Krug, Philipp Tripal, Benjamin Schmid, Carol Geppert, Arndt Hartmann, Luis E. Munoz, Janina Schoen, Simon Voelkl, Susanne Merkel, Christoph Becker, Georg Schett, Robert Gruetzmann, Elisabeth Naschberger, Martin Herrmann, Michael Stuerzl
Summary: Neutrophil extracellular traps (NETs), released by neutrophils, have been found in colorectal cancer (CRC) tissues and are associated with disease progression. This study used high-resolution microscopy to detect citrullinated NETs in colon cancer tissues and found that citrullinated NETs were significantly associated with high tumour grades and lymph node metastasis. In vitro experiments also showed that purified NETs induced filopodia formation and cell motility in CRC cell lines, indicating their potential contribution to CRC metastasis.
JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Yu-Qiang Yu, Veronika Thonn, Jay Patankar, Oana-Maria Thoma, Maximilian Waldner, Marta Zielinska, Li-li Bao, Miguel Gonzalez-Acera, Stefan Wallmueller, Felix B. Engel, Michael Stuerzl, Markus F. Neurath, Eva Liebing, Christoph Becker
Summary: This study reveals that SMYD2 is overexpressed in colorectal cancer and plays a crucial role in tumor growth while inhibiting TNF-induced apoptosis and necroptosis.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
George C. Linderman, Jun Zhao, Manolis Roulis, Piotr Bielecki, Richard A. Flavell, Boaz Nadler, Yuval Kluger
Summary: A key challenge in analyzing single cell RNA-sequencing data is the presence of a large number of false zeros. The authors propose a method based on low-rank matrix approximation to impute these false zeros while preserving true zeros. The advantages of this method are demonstrated on simulated and biological datasets.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A. Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Geza Schermann, Lena Erkert, Jay Patankar, Andromachi Karakatsani, Anna-Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Koehler, Hellmut G. Augustin, Christoph Becker, Thomas Schmidt, Carmen Ruiz de Almodovar
Summary: This study identifies Caspase-8 as a crucial factor in maintaining vascular homeostasis in the small intestine, and its deletion leads to hemorrhages and inflammation. Furthermore, Caspase-8 appears to be particularly important in lymphatic endothelial cells for maintaining gut homeostasis. The findings highlight the active role of endothelial cell dysfunction in driving chronic small intestinal inflammation and emphasize the importance of the intestinal vasculature in safeguarding organ function.
EMBO MOLECULAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Luz del Carmen Martinez-Sanchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Guenther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J. M. Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F. Neurath, Rocio Lopez-Posadas
Summary: Abnormal cell shedding is associated with intestinal barrier dysfunction and inflammatory bowel diseases. Deletion of PGGTase and RAC1 in intestinal epithelial cells leads to cell overcrowding and epithelial leakage, resulting in chronic intestinal inflammation. RAC1 plays a crucial role in regulating cytoskeletal dynamics, cell mechanics, and intestinal cell shedding.
Article
Multidisciplinary Sciences
Martin Hohmann, Ingo Ganzleben, Alexander Gruenberg, Jean Gonzales-Menezes, Florian Klaempfl, Benjamin Lengenfelder, Eva Liebing, Christina Heichler, Clemens Neufert, Christoph Becker, Markus F. Neurath, Maximilian J. Waldner, Michael Schmidt
Summary: This study evaluated the effectiveness of multispectral endoscopy in identifying neoplastic lesions in the colon and showed that the classification accuracy is comparable to hyperspectral endoscopy when additional spatial features are used. This supports the application of multi/hyperspectral endoscopy in clinical settings and addresses the challenges of transferring results from ex vivo to in vivo endoscopy.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Yu-Qiang Yu, Alexandra Herrmann, Veronika Thonn, Arne Cordsmeier, Markus F. Neurath, Armin Ensser, Christoph Becker
Summary: This study demonstrates that deficiency or inhibition of the cellular lysine-methyltransferase SMYD2 can decrease TMPRSS2 expression and effectively inhibit SARS-CoV-2 replication. Targeting cellular SMYD2 could be a promising tool for controlling COVID-19 infection.
Editorial Material
Immunology
Vasiliki Koliaraki, Gian-Paolo Dotto, Christopher D. Buckley, George Kollias
Summary: The First International Aegean Conference on Mesenchymal Cells in Health & Disease, held in Chania, Crete from 3-8 June 2022, brought together clinicians and scientists who work on mesenchymal or stromal cell biology across different fields including immunity, inflammation and cancer.
Article
Immunology
Minglu Yan, Noriko Komatsu, Ryunosuke Muro, Nam Cong-Nhat Huynh, Yoshihiko Tomofuji, Yukinori Okada, Hiroshi Suzuki, Hiroyuki Takaba, Riko Kitazawa, Sohei Kitazawa, Warunee Pluemsakunthai, Yuichi Mitsui, Takashi Satoh, Tadashi Okamura, Takeshi Nitta, Sin-Hyeog Im, Chan Johng Kim, George Kollias, Sakae Tanaka, Kazuo Okamoto, Masayuki Tsukasaki, Hiroshi Takayanagi
Summary: The transcription factor ETS1 plays a key role in regulating pathological tissue-remodeling programs in fibroblasts shared among various diseases. In arthritis, ETS1 orchestrates the polarization of tissue-destructive fibroblasts by regulating osteoclast differentiation factor RANKL and matrix metalloproteinases, impacting bone and cartilage damage. This discovery provides new insights into the mechanistic basis for pathogenic fibroblast polarization and has important therapeutic implications.
Article
Multidisciplinary Sciences
Angelika Schmalzl, Tamara Leupold, Lucas Kreiss, Maximilian Waldner, Sebastian Schuermann, Markus F. Neurath, Christoph Becker, Stefan Wirtz
Summary: IRF-1 is a transcription factor that plays a crucial role in regulating the accumulation of intestinal ILC3s and the production of effector cytokines. It is upregulated during infection to prevent pathogen dissemination and promote the release of protective cytokine IL-22. IRF-1 also allows ILC3s to physiologically respond to IL-23 stimulation by controlling their numbers and activation.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Gastroenterology & Hepatology
Christoph Becker, Timon Erik Adolph
Article
Biochemistry & Molecular Biology
Iyshwarya Balasubramanian, Sheila Bandyopadhyay, Juan Flores, Jared Bianchi-Smak, Xiang Lin, Haoran Liu, Shengxiang Sun, Natasha B. Golovchenko, Yue Liu, Dahui Wang, Radha Patel, Ivor Joseph, Panan Suntornsaratoon, Justin Vargas, Peter H. R. Green, Govind Bhagat, Stephen M. Lagana, Wang Ying, Yi Zhang, Zhihan Wang, Wei Vivian Li, Sukhwinder Singh, Zhongren Zhou, George Kollias, Laura A. Farr, Shannon N. Moonah, Shiyan Yu, Zhi Wei, Edward M. Bonder, Lanjing Zhang, Pawel R. Kiela, Karen L. Edelblum, Ronaldo Ferraris, Ta-Chiang Liu, Nan Gao
Summary: Paneth cells play a crucial role in host responses to microbiome and environmental stresses. Infection can modify the composition of Paneth cells and affect inflammation and disease progression.
