Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

Intestinal organoids as tissue surrogates for toxicological and pharmacological studies

(2013) Anton Kuratnik et al.   BIOCHEMICAL PHARMACOLOGY

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells

(2013) A Muscella et al.   Cell Death & Disease

p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD

(2012) Tatiana Goretsky et al.   AMERICAN JOURNAL OF PATHOLOGY

A nomenclature for intestinal in vitro cultures

(2012) Matthias Stelzner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human intestinal epithelial cells exhibit a cellular response indicating a potential toxicity upon exposure to hematite nanoparticles

(2012) Madhavi Kalive et al.   CELL BIOLOGY AND TOXICOLOGY

Regulation of intestinal epithelial permeability by tight junctions

(2012) Takuya Suzuki   CELLULAR AND MOLECULAR LIFE SCIENCES

Anthrax Lethal Toxin Disrupts Intestinal Barrier Function and Causes Systemic Infections with Enteric Bacteria

(2012) Chen Sun et al.   PLoS One

Genetically determined epithelial dysfunction and its consequences for microflora–host interactions

(2011) Arthur Kaser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Organic Anion Transporting Polypeptides (OATPs): Regulation of Expression and Function

(2011) Martin Svoboda et al.   CURRENT DRUG METABOLISM

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase–Bim axis and reveals glutathione-S-transferase P1 as Achilles’ heel

(2011) D Sidler et al.   ONCOGENE

Differential Effects of TNF (TNFSF2) and IFN-γ on Intestinal Epithelial Cell Morphogenesis and Barrier Function in Three-Dimensional Culture

(2011) Kati Juuti-Uusitalo et al.   PLoS One

In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF- -Induced Apoptosis and Proliferation by MAPKs

(2011) K. S. Lau et al.   Science Signaling

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

(2011) Lars Vereecke et al.   TRENDS IN MOLECULAR MEDICINE

Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner

(2010) Kathrin Schmich et al.   HEPATOLOGY

Anti-TNF-α agents in the treatment of immune-mediated inflammatory diseases: mechanisms of action and pitfalls

(2010) Léia CR Silva et al.   Immunotherapy

Importance of disrupted intestinal barrier in inflammatory bowel diseases

(2010) Saʼad Y. Salim et al.   INFLAMMATORY BOWEL DISEASES

Pathology of graft-versus-host disease in the gastrointestinal tract

(2009) Kay Washington et al.   HUMAN PATHOLOGY

Tissue-Engineered Small Intestine and Stomach Form from Autologous Tissue in a Preclinical Large Animal Model

(2009) Frédéric G. Sala et al.   JOURNAL OF SURGICAL RESEARCH

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Alteration of the Mitochondrial Apoptotic Pathway Is Key to Acquired Paclitaxel Resistance and Can Be Reversed by ABT-737

(2008) O. Kutuk et al.   CANCER RESEARCH

Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes

(2008) Sabine Jakob et al.   METHODS

In vitro approaches to evaluate palytoxin-induced toxicity and cell death in intestinal cells

(2007) I. Valverde et al.   JOURNAL OF APPLIED TOXICOLOGY