NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Inflammasomes in Intestinal Inflammation and Cancer

(2011) Grace Y. Chen et al.   GASTROENTEROLOGY

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Dendritic cell control of tolerogenic responses

(2011) Santhakumar Manicassamy et al.   IMMUNOLOGICAL REVIEWS

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

China's academic autocracy must go

(2011) Nai-Zhuo Zhao   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammasomes as microbial sensors

(2010) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammation Anergy in Human Intestinal Macrophages Is Due to Smad-induced IκBα Expression and NF-κB Inactivation

(2010) Lesley E. Smythies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens

(2010) Sarah Lebeer et al.   NATURE REVIEWS MICROBIOLOGY

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Pathogenesis of enteric Salmonella infections

(2009) Guntram A Grassl et al.   CURRENT OPINION IN GASTROENTEROLOGY

Salmonella enterica Serovar Typhimurium Pathogenicity Island 1-Encoded Type III Secretion System Translocases Mediate Intimate Attachment to Nonphagocytic Cells

(2009) M. Lara-Tejero et al.   INFECTION AND IMMUNITY

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function

(2008) Ivan Monteleone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Genetic Background and the Dilemma of Translating Mouse Studies to Humans

(2008) Juan Rivera et al.   IMMUNITY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

(2008) Katharina Brandl et al.   NATURE

Pseudomonas aeruginosa activates caspase 1 through Ipaf

(2008) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA