Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases

Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease

(2018) Heike Schmitt et al.   GUT

Cell-centred meta-analysis reveals baseline predictors of anti-TNFα non-response in biopsy and blood of patients with IBD

(2018) Renaud Gaujoux et al.   GUT

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

TNF-α exerts potent anti-rotavirus effects via the activation of classical NF-κB pathway

(2018) Mohamad S. Hakim et al.   VIRUS RESEARCH

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells

(2018) Barbara Ruder et al.   Mucosal Immunology

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway

(2018) Jun Wang et al.   Scientific Reports

Necroptosis in inflammatory bowel disease and other intestinal diseases

(2018) Sha Li et al.   World Journal of Clinical Cases

Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn’s Disease: A Phase 2a Study

(2017) Bruce E. Sands et al.   GASTROENTEROLOGY

Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease

(2017) Emily M. Bradford et al.   JOURNAL OF IMMUNOLOGY

Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn's disease: a randomised, double-blind, placebo-controlled phase 2 study

(2017) Brian G Feagan et al.   LANCET

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

Infliximab Biosimilars in the Treatment of Inflammatory Bowel Diseases: A Systematic Review

(2016) Massimo Radin et al.   BIODRUGS

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Clostridium difficile colitis: pathogenesis and host defence

(2016) Michael C. Abt et al.   NATURE REVIEWS MICROBIOLOGY

Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases

(2016) Ulrike Billmeier et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

(2016) Daniela Siegmund et al.   Cell Death & Disease

RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice

(2015) Zhe Huang et al.   Cell Host & Microbe

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

The role of Gr-1+cells and tumour necrosis factor-αsignalling duringClostridium difficilecolitis in mice

(2015) Andrew J. McDermott et al.   IMMUNOLOGY

Increased expression of tumor necrosis factor-α is associated with advanced colorectal cancer stages

(2015) Omar A Al Obeed   WORLD JOURNAL OF GASTROENTEROLOGY

Colorectal cancer severity and survival in correlation with tumour necrosis factor-alpha

(2014) Noyko Stanilov et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

TRAF-mediated modulation of NF-kB AND JNK Activation by TNFR2

(2014) Lucía Cabal-Hierro et al.   CELLULAR SIGNALLING

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

(2014) Lisa M. Sedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulation and dysregulation of tumor necrosis factor receptor-1

(2014) Leen Puimège et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

(2014) Claudia Günther et al.   GUT

In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

(2014) Raja Atreya et al.   NATURE MEDICINE

Molecular pathways controlling barrier function in IBD

(2014) Raja Atreya et al.   Nature Reviews Gastroenterology & Hepatology

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TNF-α Modulation of Intestinal Epithelial Tight Junction Barrier Is Regulated by ERK1/2 Activation of Elk-1

(2013) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PATHOLOGY

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

(2013) J. M. Williams et al.   Disease Models & Mechanisms

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

Acute infection of mice withClostridium difficileleads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response

(2013) Amir A. Sadighi Akha et al.   IMMUNOLOGY

Viral modulation of programmed necrosis

(2013) William J Kaiser et al.   Current Opinion in Virology

TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine

(2013) Denise L. Faustman et al.   Frontiers in Immunology

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

Neutralization of Membrane TNF, but Not Soluble TNF, Is Crucial for the Treatment of Experimental Colitis

(2012) Clémentine Perrier et al.   INFLAMMATORY BOWEL DISEASES

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

TNF-α converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival

(2011) Valda C. Hilliard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

Tumor necrosis factor receptor cross-talk

(2011) Petrus J. W. Naudé et al.   FEBS Journal

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair

(2011) Stefan Koch et al.   GASTROENTEROLOGY

Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages

(2011) Raja Atreya et al.   GASTROENTEROLOGY

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

(2011) R Kiesslich et al.   GUT

In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8

(2011) Ian E. Gentle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB Signal Triggering and Termination by Tumor Necrosis Factor Receptor 2

(2011) Montserrat Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis

(2011) Jacqueline E Tate et al.   LANCET INFECTIOUS DISEASES

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Wound healing of intestinal epithelial cells

(2011) Masahiro Iizuka   WORLD JOURNAL OF GASTROENTEROLOGY

Caspase deficiency alters the murine gut microbiome

(2011) B M Brinkman et al.   Cell Death & Disease

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

(2010) H.-C. REINECKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammatory Markers Are Associated With Risk of Colorectal Cancer and Chemopreventive Response to Anti-Inflammatory Drugs

(2010) Andrew T. Chan et al.   GASTROENTEROLOGY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis

(2010) Mario Noti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

(2010) Jean Frédéric Colombel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages Are Targeted by Rotavirus in Experimental Biliary Atresia and Induce Neutrophil Chemotaxis by Mip2/Cxcl2

(2010) Sujit K Mohanty et al.   PEDIATRIC RESEARCH

Rotavirus Structural Proteins and dsRNA Are Required for the Human Primary Plasmacytoid Dendritic Cell IFNα Response

(2010) Emily M. Deal et al.   PLoS Pathogens

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-α by macrophages

(2009) Xingmin Sun et al.   MICROBIAL PATHOGENESIS

Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis

(2009) Yutao Yan et al.   PLoS One

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Circulating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas

(2008) S. Kim et al.   CANCER RESEARCH

The ErbB4 Growth Factor Receptor Is Required for Colon Epithelial Cell Survival in the Presence of TNF

(2008) Mark R. Frey et al.   GASTROENTEROLOGY

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

(2008) M C Arrieta et al.   GUT

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

(2008) Boryana K. Popivanova et al.   JOURNAL OF CLINICAL INVESTIGATION

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staying alive: bacterial inhibition of apoptosis during infection

(2008) Christina S. Faherty et al.   TRENDS IN MICROBIOLOGY

Salmonellae interplay with host cells

(2007) Andrea Haraga et al.   NATURE REVIEWS MICROBIOLOGY