Autophagy as a potential therapeutic target in intervertebral disc degeneration

The circadian rhythm in intervertebral disc degeneration: an autophagy connection

(2020) Tai-Wei Zhang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Bromodomain‐containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells

(2020) Junmin Hong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Meta-analysis of the therapeutic effect of acupuncture and chiropractic on cervical spondylosis radiculopathy

(2020) Ping Wang et al.   MEDICINE

Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc

(2020) Fan Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Interleukin-17A Promotes Human Disc Degeneration by Inhibiting Autophagy Through the Activation of the Phosphatidylinositol 3-Kinase/Akt/Bcl2 Signaling Pathway

(2020) Wen-Si He et al.   World Neurosurgery

Curcumin prevents tension-induced endplate cartilage degeneration by enhancing autophagy

(2020) Liang Xiao et al.   LIFE SCIENCES

Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition

(2019) Yu Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin benefits to the growth of human annulus fibrosus cells through inhibiting miR-106a-5p/ATG7 signaling pathway

(2019) Bao Hai et al.   Clinical Interventions in Aging

Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells

(2019) Rui Zuo et al.   STEM CELLS

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

(2019) Y. Kakiuchi et al.   OSTEOARTHRITIS AND CARTILAGE

Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study

(2019) Takashi Yurube et al.   EUROPEAN SPINE JOURNAL

Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link?

(2019) Clara Ruiz-Fernández et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy

(2019) Jiangwei Chen et al.   BIOSCIENCE REPORTS

BRD4 inhibition regulates MAPK, NF-κB signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration

(2019) Jianle Wang et al.   FASEB JOURNAL

Berberine ameliorates oxidative stress-induced apoptosis by modulating ER stress and autophagy in human nucleus pulposus cells

(2019) Rongjin Luo et al.   LIFE SCIENCES

Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells

(2019) Weiwei Yi et al.   Aging-US

lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells

(2019) Shengfeng Zhan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Duhuo jisheng decoction suppresses matrix degradation and apoptosis in human nucleus pulposus cells and ameliorates disc degeneration in a rat model

(2019) Wei Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses

(2019) Liang Kang et al.   LIFE SCIENCES

PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy

(2018) Yiyang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage

(2018) Jinlou Gao et al.   BIOSCIENCE REPORTS

Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation

(2018) Fang Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model

(2018) Yu Chen et al.   International Journal of Biological Sciences

Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration

(2018) Zengming Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis

(2018) Hyowon Choi et al.   MATRIX BIOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and its Role in Plant Abiotic Stress Management

(2018) Tamar Avin-Wittenberg   PLANT CELL AND ENVIRONMENT

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

(2018) Jian Chen et al.   Cell Death & Disease

Mechanisms of endogenous repair failure during intervertebral disc degeneration

(2018) K. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

(2018) Zengjie Zhang et al.   Cell Death & Disease

Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway

(2018) Zengjie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux

(2018) Gang Zheng et al.   OSTEOARTHRITIS AND CARTILAGE

Estradiol Alleviates Intervertebral Disc Degeneration through Modulating the Antioxidant Enzymes and Inhibiting Autophagy in the Model of Menopause Rats

(2018) Lin-Yu Jin et al.   Oxidative Medicine and Cellular Longevity

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

(2017) M. Ito et al.   OSTEOARTHRITIS AND CARTILAGE

Cell therapy for the degenerating intervertebral disc

(2017) Wei Tong et al.   Translational Research

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

(2016) Hyowon Choi et al.   Autophagy

Resveratrol attenuated TNF-α–induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway

(2016) Xiao-Hu Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

(2016) Eleftherios Karanasios et al.   Nature Communications

Activation of autophagy via Ca2+-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress

(2015) Li-Bo Jiang et al.   CELL CYCLE

Mechanisms of development of multimorbidity in the elderly

(2015) Peter J. Barnes   EUROPEAN RESPIRATORY JOURNAL

Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130

(2015) Justin Joachim et al.   MOLECULAR CELL

Autophagy in the Degenerating Human Intervertebral Disc

(2015) Helen E. Gruber et al.   SPINE

Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification

(2014) Hong-guang Xu et al.   BONE

The effect of transforming growth factor β1 on the crosstalk between autophagy and apoptosis in the annulus fibrosus cells under serum deprivation

(2014) Bin-Bin Ni et al.   CYTOKINE

Organellophagy: Eliminating cellular building blocks via selective autophagy

(2014) Koji Okamoto   JOURNAL OF CELL BIOLOGY

Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR-dependent pathway

(2014) LiBo Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

(2014) Daniel Papinski et al.   MOLECULAR CELL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

The role of endplate poromechanical properties on the nutrient availability in the intervertebral disc

(2014) A. Malandrino et al.   OSTEOARTHRITIS AND CARTILAGE

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

The State of US Health, 1990-2010

(2013) Christopher J. L. Murray   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

(2013) K.-G. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions

(2010) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanical design criteria for intervertebral disc tissue engineering

(2010) Nandan L. Nerurkar et al.   JOURNAL OF BIOMECHANICS

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

(2010) Nobumichi Furuta et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Trend in Total Cost of Back Pain in the Netherlands in the Period 2002 to 2007

(2010) Ludeke C. Lambeek et al.   SPINE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Multiple roles of the cytoskeleton in autophagy

(2009) Iryna Monastyrska et al.   BIOLOGICAL REVIEWS

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Expenditures and Health Status Among Adults With Back and Neck Problems

(2008) Brook I. Martin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The pathophysiology of disc degeneration

(2008) A. G. Hadjipavlou et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Intervertebral Disc: Anatomy-Physiology-Pathophysiology-Treatment

(2008) P. Prithvi Raj   Pain Practice