Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration

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Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12

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Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermineN1-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells

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Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

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Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

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Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling, vimentin-positive cells and cell death

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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

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Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

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Can autophagy promote longevity?

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Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

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Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

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Induction of autophagy by spermidine promotes longevity

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Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model

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A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

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