The circadian rhythm in intervertebral disc degeneration: an autophagy connection

Diurnal Rhythms Spatially and Temporally Organize Autophagy

(2019) Mikhail Ryzhikov et al.   Cell Reports

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction

(2019) Y. Kakiuchi et al.   OSTEOARTHRITIS AND CARTILAGE

Circadian-Regulated Cell Death in Cardiovascular Diseases

(2019) Inna Rabinovich-Nikitin et al.   CIRCULATION

Casein kinase 1α: biological mechanisms and theranostic potential

(2018) Shaojie Jiang et al.   Cell Communication and Signaling

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

(2018) Miriam Toledo et al.   Cell Metabolism

Melatonin as an endogenous regulator of diseases: The role of autophagy

(2018) Ali Roohbakhsh et al.   PHARMACOLOGICAL RESEARCH

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

(2018) Gabriele Sulli et al.   NATURE

Acrylamide aggravates cognitive deficits at night period via the gut–brain axis by reprogramming the brain circadian clock

(2018) Xintong Tan et al.   ARCHIVES OF TOXICOLOGY

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

(2018) Rong Wu et al.   Cell Metabolism

Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy

(2018) Lu Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Daily Regulation of Phototransduction, Circadian Clock, DNA Repair, and Immune Gene Expression by Heme Oxygenase in the Retina of Drosophila

(2018) Milena Damulewicz et al.   Genes

Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart

(2017) Graham R. McGinnis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy

(2017) Yichao Zhao et al.   JOURNAL OF PINEAL RESEARCH

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

(2017) M. Ito et al.   OSTEOARTHRITIS AND CARTILAGE

Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes

(2017) R. Akagi et al.   OSTEOARTHRITIS AND CARTILAGE

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus

(2017) Chao Liu et al.   Scientific Reports

TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in behavior and plasticity of L2 interneurons in the brain of Drosophila melanogaster

(2017) Ewelina Kijak et al.   PLoS One

IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells

(2017) Jieliang Shen et al.   Scientific Reports

Crosstalk of clock gene expression and autophagy in aging

(2016) Faiza Kalfalah et al.   Aging-US

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

(2016) Michal Dudek et al.   ANNALS OF THE RHEUMATIC DISEASES

The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish

(2016) Guodong Huang et al.   Autophagy

Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasiveEscherichia coliinfection

(2016) Alexis Bretin et al.   Autophagy

Circadian rhythm of autophagy proteins in hippocampus is blunted by sleep fragmentation

(2016) Yi He et al.   CHRONOBIOLOGY INTERNATIONAL

Regulation of the clock gene expression in human adipose tissue by weight loss

(2016) O Pivovarova et al.   INTERNATIONAL JOURNAL OF OBESITY

Deep RNA profiling identified CLOCK and molecular clock genes as pathophysiological signatures in collagen VI myopathy

(2016) Chiara Scotton et al.   JOURNAL OF CELL SCIENCE

The nuclear melatonin receptor RORαis a novel endogenous defender against myocardial ischemia/reperfusion injury

(2016) Ben He et al.   JOURNAL OF PINEAL RESEARCH

Effects of Per2 overexpression on growth inhibition and metastasis, and on MTA1, nm23-H1 and the autophagy-associated PI3K/PKB signaling pathway in nude mice xenograft models of ovarian cancer

(2016) ZHAOXIA WANG et al.   Molecular Medicine Reports

Folate deprivation modulates the expression of autophagy- and circadian-related genes in HT-22 hippocampal neuron cells through GR-mediated pathway

(2016) Qinwei Sun et al.   STEROIDS

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

(2016) Kaori Suyama et al.   Oncotarget

Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments

(2016) Guillermo Coronas-Samano et al.   Frontiers in Aging Neuroscience

Activation of autophagy via Ca2+-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress

(2015) Li-Bo Jiang et al.   CELL CYCLE

Interleukin-1β in intervertebral disk degeneration

(2015) Wei Yang et al.   CLINICA CHIMICA ACTA

Hypoxia facilitates the survival of nucleus pulposus cells in serum deprivation by down-regulating excessive autophagy through restricting ROS generation

(2015) Jiang-Wei Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition

(2015) KANG XU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Passive cigarette smoking changes the circadian rhythm of clock genes in rat intervertebral discs

(2015) Shumpei Numaguchi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Structural integration in hypoxia-inducible factors

(2015) Dalei Wu et al.   NATURE

Autophagy in the Degenerating Human Intervertebral Disc

(2015) Helen E. Gruber et al.   SPINE

Establishment of intervertebral disc degeneration model induced by ischemic sub-endplate in rat tail

(2015) Wei Yuan et al.   Spine Journal

Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta

(2015) Xigui Chen et al.   Scientific Reports

WIPI-Mediated Autophagy and Longevity

(2015) Mona Grimmel et al.   Cells

Dual attenuation of proteasomal and autophagic BMAL1 degradation in ClockΔ19/+ mice contributes to improved glucose homeostasis

(2015) Kwon Jeong et al.   Scientific Reports

Metabolic and Nontranscriptional Circadian Clocks: Eukaryotes

(2014) Akhilesh B. Reddy et al.   Annual Review of Biochemistry

Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification

(2014) Hong-guang Xu et al.   BONE

Autophagy and ER-stress contribute to photoreceptor degeneration in cultured adult porcine retina

(2014) Camilla Mohlin et al.   BRAIN RESEARCH

Circadian control of tissue homeostasis and adult stem cells

(2014) Peggy Janich et al.   CURRENT OPINION IN CELL BIOLOGY

Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

(2014) Anorut Jenwitheesuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium

(2014) Laura S. Frost et al.   MOLECULAR NEUROBIOLOGY

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

(2014) C De Mei et al.   ONCOGENE

Connecting cellular metabolism to circadian clocks

(2013) Guillaume Rey et al.   TRENDS IN CELL BIOLOGY

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

The evidence and the possible significance of autophagy in degeneration model of human cervical end-plate cartilage

(2013) HONGGUANG XU et al.   Experimental and Therapeutic Medicine

Diversity of intervertebral disc cells: phenotype and function

(2012) Girish Pattappa et al.   JOURNAL OF ANATOMY

The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism

(2012) Xiwen Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus

(2011) Wei Ye et al.   CONNECTIVE TISSUE RESEARCH

Temporal orchestration of circadian autophagy rhythm by C/EBPβ

(2011) Di Ma et al.   EMBO JOURNAL

Effects of aging and degeneration on the human intervertebral disc during the diurnal cycle: A finite element study

(2011) Christopher J. Massey et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin

(2011) Virginia Motilva et al.   JOURNAL OF PINEAL RESEARCH

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in rat annulus fibrosus cells: evidence and possible implications

(2011) Chao Shen et al.   ARTHRITIS RESEARCH & THERAPY

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy

(2010) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells

(2010) Yeong-Min Yoo et al.   JOURNAL OF PINEAL RESEARCH

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes

(2009) Eisuke Itakura et al.   Autophagy

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

SIRT1 Is a Circadian Deacetylase for Core Clock Components

(2008) William J. Belden et al.   CELL

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells

(2008) Patthara Kongsuphol et al.   JOURNAL OF PINEAL RESEARCH

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA