Active autophagy in cancer‐associated fibroblasts: Recent advances in understanding the novel mechanism of tumor progression and therapeutic response

Paracrine TGF-β1 from breast cancer contributes to chemoresistance in cancer associated fibroblasts via upregulation of the p44/42 MAPK signaling pathway

(2021) Bikash Chandra Jena et al.   BIOCHEMICAL PHARMACOLOGY

Tumor microenvironment differences between primary tumor and brain metastases

(2020) Bernardo Cacho-Díaz et al.   Journal of Translational Medicine

Crosstalk between autophagy and metabolic regulation of cancer stem cells

(2020) Mouradi El Hout et al.   Molecular Cancer

The emerging roles of exosomes in anti-cancer drug resistance and tumor progression: An insight towards tumor-microenvironment interaction

(2020) Bikash Chandra Jena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cancer associated fibroblast mediated chemoresistance: A paradigm shift in understanding the mechanism of tumor progression

(2020) Bikash Chandra Jena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A role for stromal autophagy in cancer-associated fibroblast activation

(2019) Sandro Goruppi et al.   Autophagy

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

(2019) Francesca Nazio et al.   CELL DEATH AND DIFFERENTIATION

Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy

(2019) Dhruba Kadel et al.   CELL BIOLOGY AND TOXICOLOGY

The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer

(2019) Yuanliang Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1

(2019) Julia Ketteler et al.   Journal of Clinical Medicine

Autophagy and mitophagy in cancer metabolic remodelling

(2019) Fabio Ferro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance

(2019) Deblina Bharadwaj et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Reprogramming tumor stroma using an endogenous lipid lipoxin A4 to treat pancreatic cancer

(2018) Jonas Schnittert et al.   CANCER LETTERS

LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates

(2018) James W. Purcell et al.   CANCER RESEARCH

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

(2018) Lan Thi Hanh Phi et al.   Stem Cells International

Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice

(2018) Xiangliang Deng et al.   Journal of Immunology Research

Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy

(2018) Adriana Albini et al.   Frontiers in Immunology

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma

(2018) Xinqun Li et al.   CELL DEATH AND DIFFERENTIATION

Cutting Edge: NANOG Activates Autophagy under Hypoxic Stress by Binding to BNIP3L Promoter

(2017) Meriem Hasmim et al.   JOURNAL OF IMMUNOLOGY

High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells

(2017) Xi-Long Zhao et al.   JOURNAL OF PATHOLOGY

Dual role of autophagy in hallmarks of cancer

(2017) Shikha Satendra Singh et al.   ONCOGENE

Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy

(2017) Shana D. Hardy et al.   Oncotarget

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

Cancer-Associated Fibroblasts Autophagy Enhances Progression of Triple-Negative Breast Cancer Cells

(2017) Mengchuan Wang et al.   MEDICAL SCIENCE MONITOR

NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly

(2016) Candia M. Kenific et al.   Autophagy

Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells

(2016) Wenjing Zhou et al.   CELL CYCLE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy

(2016) Yong Jiang et al.   NATURE CELL BIOLOGY

Autophagy in cancer metastasis

(2016) E E Mowers et al.   ONCOGENE

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

p53-mediated autophagic regulation: A prospective strategy for cancer therapy

(2015) Juanjuan Tang et al.   CANCER LETTERS

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib

(2015) S Jagannathan et al.   LEUKEMIA

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Immune Response Regulation in the Tumor Microenvironment by Hypoxia

(2015) Sara Labiano et al.   SEMINARS IN ONCOLOGY

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

The Selective Autophagy Receptor p62 Forms a Flexible Filamentous Helical Scaffold

(2015) Rodolfo Ciuffa et al.   Cell Reports

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway

(2015) Hongyu Zhou et al.   Oncotarget

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

(2014) Nathalie M. Mazure et al.   Autophagy

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

(2014) Giovanni Pagano et al.   Oxidative Medicine and Cellular Longevity

Loss of Stromal Caveolin-1 Expression: A Novel Tumor Microenvironment Biomarker That Can Predict Poor Clinical Outcomes for Pancreatic Cancer

(2014) Tao Shan et al.   PLoS One

CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2

(2014) K Liu et al.   Cell Death & Disease

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells

(2013) Jaganmohan Reddy Jangamreddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prognostic role of caveolin in breast cancer: A meta-analysis

(2013) Xuelei Ma et al.   BREAST

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease

(2013) JIANHUA JIANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Autophagy: shaping the tumor microenvironment and therapeutic response

(2013) Hannelore Maes et al.   TRENDS IN MOLECULAR MEDICINE

AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway

(2012) Rui Kang et al.   Autophagy

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

(2012) Barbara Chiavarina et al.   CANCER BIOLOGY & THERAPY

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

Autophagy in tumor suppression and cancer therapy

(2012) Che-Pei Kung et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Breast cancer-associated fibroblasts induce epithelial-to-mesenchymal transition in breast cancer cells

(2012) Patsy S H Soon et al.   ENDOCRINE-RELATED CANCER

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

(2012) A Avivar-Valderas et al.   ONCOGENE

Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells

(2012) Chien-Ju Lin et al.   PLoS One

DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs

(2012) M. Badura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

A critical role for UVRAG in apoptosis

(2011) Xiaocheng Yin et al.   Autophagy

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy inC. elegans

(2011) Alexander Ruck et al.   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy

(2011) Scott Thomas et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

(2011) Paolo Cirri et al.   CANCER AND METASTASIS REVIEWS

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Interactions between tumor cells and microenvironment in breast cancer: A new opportunity for targeted therapy

(2011) Shreya Mitra et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Zinc Ionophore PCI-5002 Radiosensitizes Non-small Cell Lung Cancer Cells by Enhancing Autophagic Cell Death

(2011) Kwang Woon Kim et al.   Journal of Thoracic Oncology

ROS Signaling by NOX4 Drives Fibroblast-to-Myofibroblast Differentiation in the Diseased Prostatic Stroma

(2011) Natalie Sampson et al.   MOLECULAR ENDOCRINOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study

(2011) S Shen et al.   ONCOGENE

Glutaminolysis yields a metabolic by-product that stimulates autophagy

(2010) Christina H. Eng et al.   Autophagy

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Regulation of autophagy by extracellular matrix glycoproteins in HeLa cells

(2010) Véronique Tuloup-Minguez et al.   Autophagy

Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes

(2010) Paola Marambio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prevention of cancer by inhibiting aging

(2010) Mikhail V Blagosklonny   CANCER BIOLOGY & THERAPY

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Cytoprotective roles for autophagy

(2010) Kevin Moreau et al.   CURRENT OPINION IN CELL BIOLOGY

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

BRCA1 negatively regulates formation of autophagic vacuoles in MCF-7 breast cancer cells

(2010) Juan M. Esteve et al.   EXPERIMENTAL CELL RESEARCH

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Chemical modulators of autophagy as biological probes and potential therapeutics

(2010) Angeleen Fleming et al.   Nature Chemical Biology

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

The paradox of autophagy and its implication in cancer etiology and therapy

(2009) Avital Eisenberg-Lerner et al.   APOPTOSIS

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy and tumorigenesis

(2009) Nan Chen et al.   FEBS LETTERS

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism

(2008) Xin-Hua Liao et al.   AMINO ACIDS

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE