Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

(2011) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

Gap Junction-Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells

(2011) P. K. Lim et al.   CANCER RESEARCH

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors

(2011) Hiroshi Tazawa et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

(2011) M Musumeci et al.   ONCOGENE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Cancer-Associated Fibroblasts Enhance the Gland-Forming Capability of Prostate Cancer Stem Cells

(2010) C.-P. Liao et al.   CANCER RESEARCH

Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

(2010) N. Kobayashi et al.   CANCER RESEARCH

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

On the origin of cancer-associated fibroblasts

(2010) Charlotte Anderberg et al.   CELL CYCLE

The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts

(2010) Olga Aprelikova et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients

(2010) Boye Schnack Nielsen et al.   CLINICAL & EXPERIMENTAL METASTASIS

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Activation of fibroblasts in cancer stroma

(2010) Kati Räsänen et al.   EXPERIMENTAL CELL RESEARCH

Micro-RNA-21 regulates TGF-β-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction

(2010) Qin Yao et al.   INTERNATIONAL JOURNAL OF CANCER

Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer

(2010) Tony Blick et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

(2010) Kusumawadee Utispan et al.   Molecular Cancer

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis

(2010) A K Mitra et al.   ONCOGENE

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

(2010) A N Santhanam et al.   ONCOGENE

A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

(2010) Ivo J. Huijbers et al.   PLoS One

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Chemokines in tumor-associated angiogenesis

(2009) Peter Arne Gerber et al.   BIOLOGICAL CHEMISTRY

Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma

(2009) Masayuki Nakao et al.   CANCER

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

(2009) Yongping Crawford et al.   CANCER CELL

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma In situ

(2009) C. Jedeszko et al.   CANCER RESEARCH

MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma

(2009) Wiltrud Lederle et al.   CARCINOGENESIS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature

(2009) George J. Klarmann et al.   CLINICAL & EXPERIMENTAL METASTASIS

Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

(2009) W. Wang et al.   CLINICAL CANCER RESEARCH

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling

(2009) Francesco Blasi et al.   FEBS LETTERS

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Ovarian cancer cells stimulate uPA gene expression in fibroblastic stromal cells via multiple paracrine and autocrine mechanisms

(2009) Vera Noskova et al.   GYNECOLOGIC ONCOLOGY

p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy

(2009) Takahiro Hasebe et al.   HUMAN PATHOLOGY

Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion

(2009) Silvia Vosseler et al.   INTERNATIONAL JOURNAL OF CANCER

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer

(2009) Roopali Roy et al.   JOURNAL OF CLINICAL ONCOLOGY

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Podoplanin Expression Identified in Stromal Fibroblasts as a Favorable Prognostic Marker in Patients with Colorectal Carcinoma

(2009) Takahiro Yamanashi et al.   ONCOLOGY

Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast

(2009) M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth

(2009) M. Augsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Seprase: An overview of an important matrix serine protease

(2008) Pamela O'Brien et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

(2008) J P Dean et al.   BRITISH JOURNAL OF CANCER

Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

(2008) S.-Y. Sung et al.   CANCER RESEARCH

A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer

(2008) M.-P. Wu et al.   CARCINOGENESIS

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front

(2008) Olivier Wever et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Stromal myofibroblasts are drivers of invasive cancer growth

(2008) Olivier De Wever et al.   INTERNATIONAL JOURNAL OF CANCER

CXCL8/IL-8 and CXCL12/SDF-1α co-operatively promote invasiveness and angiogenesis in pancreatic cancer

(2008) Yoichi Matsuo et al.   INTERNATIONAL JOURNAL OF CANCER

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Growth control by intracellular tension and extracellular stiffness

(2008) Richard K. Assoian et al.   TRENDS IN CELL BIOLOGY

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

(2008) Kristian Pietras et al.   PLOS MEDICINE