Review
Biochemistry & Molecular Biology
Michael Rangel, Jerry Kong, Vrushank Bhatt, Khoosheh Khayati, Jessie Yanxiang Guo
Summary: Autophagy is a crucial cellular process that degrades waste and recycles nutrients to maintain cellular homeostasis. In cancer, upregulated autophagy supports tumor growth and survival through various mechanisms, making it a potential target for novel cancer treatments.
Review
Oncology
Yong Shi, Erik Norberg, Helin Vakifahmetoglu-Norberg
Summary: The article discusses the mutation of the TP53 gene in cancer and its regulatory role in autophagy, explores the potential role of mutant p53 proteins in different autophagic pathways, and discusses potential strategies for targeting mutant p53 in cancer treatment through autophagy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Anni Laine, Srikar G. Nagelli, Caroline Farrington, Umar Butt, Anna N. Cvrljevic, Julia P. Vainonen, Femke M. Feringa, Tove J. Gronroos, Prson Gautam, Sofia Khan, Harri Sihto, Xi Qiao, Karolina Pavic, Denise C. Connolly, Pauliina Kronqvist, Laura L. Elo, Jochen Maurer, Krister Wennerberg, Rene H. Medema, Heikki Joensuu, Emilia Peuhu, Karin de Visser, Goutham Narla, Jukka Westermarck
Summary: CIP2A plays a crucial role in basal-like breast cancer by influencing DNA damage-induced mitotic checkpoint and cell proliferation, driving disease initiation and progression.
Article
Biochemistry & Molecular Biology
Olga Fedorova, Alexandra Daks, Sergey Parfenyev, Oleg Shuvalov, Sofia Netsvetay, Julia Vasileva, Anastasia Gudovich, Vasilii Golotin, Oleg Semenov, Alexey Petukhov, Ekaterina Baiduik, Nurken Berdigaliyev, Eugene M. Tulchinsky, Nikolai A. Barlev
Summary: The text delves into the role of autophagy in cellular processes, exploring the relationship between autophagy and DNA damage, as well as the mechanisms through which tumor cells and breast cancer cells handle anticancer drugs and drug resistance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Maria Dolores Salinas, Rut Valdor
Summary: This review investigates the role of chaperone-mediated autophagy (CMA) induced by glioblastoma (GB) in peritumoral pericytes (PCs), and evaluates how manipulating this process could be a new strategy to fight against GB. The results suggest that regulating CMA activity may offer new treatment options, and the use of modified PCs as a cell therapy alternative is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mei Chen, Xuelan Chen, Shujun Li, Xiangyu Pan, Yanqiu Gong, Jianan Zheng, Jing Xu, Chengjian Zhao, Qi Zhang, Shan Zhang, Lu Qi, Zhongwang Wang, Kaidou Shi, Bi-Sen Ding, Zhihong Xue, Lu Chen, Shengyong Yang, Yuan Wang, Ting Niu, Lunzhi Dai, Scott W. Lowe, Chong Chen, Yu Liu
Summary: This study identifies PHF23 as a new tumor suppressor gene on chromosome 17p, which forms a previously unreported histone-modifying complex, the PSH complex, to regulate gene activation through a synergistic link between H3K4me3 and H3K27ac. Disruption of the PSH complex is crucial for the development and maintenance of PHF23-deficient and 17p-deleted tumors, revealing a novel epigenetic regulatory mechanism in 17p-deleted cancers.
Review
Immunology
Shuang-Lan Chen, Chun-Meng Li, Wei Li, Qing-Song Liu, Shuang-Yuan Hu, Mao-Yuan Zhao, Dong-Sen Hu, Yan-Wei Hao, Jin-Hao Zeng, Yi Zhang
Summary: Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation in the intestines, and the link between autophagy and intestinal health has been widely studied. This review focuses on how autophagy alleviates IBD through specific genes, crosstalk with multiple phenotypes, and autophagy-associated signaling pathways. Understanding the mechanism of autophagy in IBD can provide references for future therapeutic drug development and disease management.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Alerie G. de la Fuente, Silvia Pelucchi, Jerome Mertens, Monica Di Luca, Daniela Mauceri, Elena Marcello
Summary: Ageing is the main risk factor for most primary neurodegenerative disorders, and protein misfolding and toxic protein accumulation are considered causative events. However, other biological pathways affected by brain ageing also contribute to pathogenesis. This article discusses the involvement of mechanisms controlling neuronal structure, gene expression, autophagy, cell metabolism, and neuroinflammation in the onset and progression of neurodegenerative disorders, and reviews therapeutic strategies aiming to normalize these pathways for increased brain resilience.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amina Jamal Laham, Maha Saber-Ayad, Raafat El-Awady
Summary: DYRK1A is a dual kinase involved in Down syndrome and plays a critical role in tumorigenesis. It can phosphorylate itself and substrates, having dual effects on tumor development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Xuhong Song, Lulu Zhou, Wenrui Yang, Xinyan Li, Jiazi Ma, Kun Qi, Rui Liang, Meijing Li, Lingzhu Xie, Tin Su, Dongyang Huang, Bin Liang
Summary: PHLDA1 is a multifunctional protein that plays diverse roles in various biological processes, and its altered expression has been found in different types of cancer. This study explored the regulatory mechanism of p53 on PHLDA1 and confirmed the direct regulation of PHLDA1 by p53 through changes in the acetylation and methylation levels in the promoter region. The findings further highlight the important role of PHLDA1 in cell fate determination.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Oncology
Xiang Li, Yuan Lyu, Junqi Li, Xinjun Wang
Summary: AMBRA1 is an intrinsically disordered protein that regulates autophagy and plays a role in cancer cell survival and death. It can inhibit tumor formation and progression by regulating c-MYC and cyclins. This review focuses on the mechanisms and roles of AMBRA1 in autophagy, mitophagy, apoptosis, tumorigenesis, and targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Che-Pei Kung, Jason D. Weber
Summary: The relationship between P53, MDM2, and ARF plays a crucial role in tumor suppression mechanisms, but our understanding of this relationship needs to be updated in order to develop more effective cancer treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Meimei Wang, Zhenyu Yang, Yang Song, Pengfei Wei, Nestor Ishiwme, Liansheng Wang, Hao Zhang, Manman Jing, Meng Gao, Longping Wen, Yunjiao Zhang
Summary: This article investigates the degradation of mutant p53 proteins by AIE-Mit-TPP and the impact of autophagy on this degradation. The results show that AIE-Mit-TPP induces proteasomal degradation of mutp53 proteins and inhibits their gain-of-function properties, while also causing mitochondrial damage and autophagy. Inhibition of autophagy further enhances the degradation of mutp53 by AIE-Mit-TPP and suppresses cell proliferation and migration, leading to cell cycle arrest and cell death. Therefore, AIE-Mit-TPP has an inhibitory effect on the growth of p53-mutated tumors.
ACTA BIOMATERIALIA
(2022)
Review
Oncology
Adria Hasan, Suroor Fatima Rizvi, Sana Parveen, Neelam Pathak, Aamir Nazir, Snober S. Mir
Summary: Cancer formation is a complex process regulated by the microenvironment. Autophagy and ROS play important regulatory roles in cancer development, but their effects are multifaceted. This review explores the regulatory roles of autophagy and ROS from tumor induction to metastasis, as well as discussing therapeutic strategies and research gaps in cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Thi Thanh Vu, Friedrich Stoelzel, Kristy W. Wang, Christoph Roellig, Melinda L. Tursky, Timothy J. Molloy, David D. Ma
Summary: Inhibition of MDM2/4 to activate p53 has shown promise in the treatment of AML. MiR-10a overexpression in AML regulates key members of the p53/Rb pathway and predicts sensitivity to MDM2 inhibitors, making it a potential biomarker and drug target to enhance treatment efficacy.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.