Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions

Structural basis for adhesion G protein-coupled receptor Gpr126 function

(2020) Katherine Leon et al.   Nature Communications

ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder

(2019) Djenifer B. Kappel et al.   NEUROMOLECULAR MEDICINE

Hair-Bundle Links: Genetics as the Gateway to Function

(2019) Guy P. Richardson et al.   Cold Spring Harbor Perspectives in Medicine

MicroRNA-503-5p Inhibits the CD97-Mediated JAK2/STAT3 Pathway in Metastatic or Paclitaxel-Resistant Ovarian Cancer Cells

(2019) Ga Bin Park et al.   NEOPLASIA

Adhesion G-protein coupled receptors: Implications for metabolic function

(2019) Oladapo E. Olaniru et al.   PHARMACOLOGY & THERAPEUTICS

Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma

(2019) Karsten Kleo et al.   BMC CANCER

Novel Usher syndrome pathogenic variants identified in cases with hearing and vision loss

(2019) Justin A. Pater et al.   BMC Medical Genetics

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

(2019) Haiwei Chen et al.   CELL

Adhesion G protein-coupled receptors: opportunities for drug discovery

(2019) Frederic Bassilana et al.   NATURE REVIEWS DRUG DISCOVERY

GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine

(2019) Taeyeop Park et al.   Journal of Neuroinflammation

A Whole-Exome Sequencing Study of Tourette Disorder in a Chinese Population

(2019) Xin Zhao et al.   DNA AND CELL BIOLOGY

Adhesion G Protein–Coupled Receptors as Drug Targets

(2018) Ryan H. Purcell et al.   Annual Review of Pharmacology and Toxicology

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer

(2018) Raksha R. Bhat et al.   BREAST CANCER RESEARCH AND TREATMENT

The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

(2018) Oladapo E. Olaniru et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

N- Docosahexaenoylethanolamine: A neurotrophic and neuroprotective metabolite of docosahexaenoic acid

(2018) Hee-Yong Kim et al.   MOLECULAR ASPECTS OF MEDICINE

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

The colorful spectrum of Tourette syndrome and its medical, surgical and behavioral therapies

(2018) Jan Roth   PARKINSONISM & RELATED DISORDERS

Cancer Cell Mechanics: Adhesion G Protein-coupled Receptors in Action?

(2018) Nicole Scholz   Frontiers in Oncology

Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci

(2018) Anas M Khanshour et al.   HUMAN MOLECULAR GENETICS

Complement 1q like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein–coupled receptor BAI3

(2018) Rajesh Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT)

(2018) Canan G. Nebigil et al.   TRENDS IN CARDIOVASCULAR MEDICINE

A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis

(2018) Ikuyo Kou et al.   Scientific Reports

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

(2018) Sheng Wang et al.   Cell Reports

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association

(2018) Mary Ella Pierpont et al.   CIRCULATION

LPHN3 gene variations and susceptibility to ADHD in Chinese Han population: a two-stage case–control association study and gene–environment interactions

(2018) Xin Huang et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

(2018) Noumeira Hamoud et al.   Nature Communications

High-throughput sequencing for the molecular diagnosis of Usher syndrome reveals 42 novel mutations and consolidates CEP250 as Usher-like disease causative

(2018) Carla Fuster-García et al.   Scientific Reports

ADGRV1 is implicated in myoclonic epilepsy

(2017) Kenneth A. Myers et al.   EPILEPSIA

A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2 ) increases receptor signaling activity

(2017) Ryan H. Purcell et al.   HUMAN MUTATION

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

(2017) Catherine J. Hutchings et al.   NATURE REVIEWS DRUG DISCOVERY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Genetics of coronary artery disease: discovery, biology and clinical translation

(2017) Amit V. Khera et al.   NATURE REVIEWS GENETICS

De Novo Coding Variants Are Strongly Associated with Tourette Disorder

(2017) A. Jeremy Willsey et al.   NEURON

GPCRdb in 2018: adding GPCR structure models and ligands

(2017) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction

(2017) Baptiste Libé-Philippot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Variant of GPR126 Gene is Functionally Associated With Adolescent Idiopathic Scoliosis in Chinese Population

(2017) Xiaodong Qin et al.   SPINE

GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma

(2017) Marta Moreno et al.   Cell Reports

Periodontal diseases

(2017) Denis F. Kinane et al.   Nature Reviews Disease Primers

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

(2016) C. Pabst et al.   BLOOD

Genetic analysis of rare coding mutations in CELSR1-3 in Chinese Congenital Heart and Neural Tube Defects

(2016) X. Qiao et al.   CLINICAL SCIENCE

Adhesion G Protein-Coupled Receptor G1 (ADGRG1/GPR56) and Pancreatic β-Cell Function

(2016) Pontus Dunér et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population

(2016) Jirouta Kitagaki et al.   PLoS One

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function

(2016) Ji-Won Lee et al.   Nature Communications

Mutations of GPR126 Are Responsible for Severe Arthrogryposis Multiplex Congenita

(2015) Gianina Ravenscroft et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish

(2015) Breanne L Harty et al.   BMC GENOMICS

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

(2015) Ekaterina Posokhova et al.   Cell Reports

Adolescent idiopathic scoliosis

(2015) Jack C. Cheng et al.   Nature Reviews Disease Primers

miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124

(2014) Yi Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Constitutive GαiCoupling Activity of Very Large G Protein-coupled Receptor 1 (VLGR1) and Its Regulation by PDZD7 Protein

(2014) Qiao-Xia Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of CD97 Expression and Manipulation: Antibody Treatment but Not Gene Targeting Curtails Granulocyte Migration

(2014) H. Veninga et al.   JOURNAL OF IMMUNOLOGY

Understanding cadherin EGF LAG seven-pass G-type receptors

(2014) Xiao-Jing Wang et al.   JOURNAL OF NEUROCHEMISTRY

Changes in BAI1 and Nestin Expression Are Prognostic Indicators for Survival and Metastases in Breast Cancer and Provide Opportunities for Dual Targeted Therapies

(2014) W. H. Meisen et al.   MOLECULAR CANCER THERAPEUTICS

Identification of Novel CELSR1 Mutations in Spina Bifida

(2014) Yunping Lei et al.   PLoS One

Transcriptome Profiling of a Multiple Recurrent Muscle-Invasive Urothelial Carcinoma of the Bladder by Deep Sequencing

(2014) Shufang Zhang et al.   PLoS One

Skeletal Muscle Expression of the Adhesion-GPCR CD97: CD97 Deletion Induces an Abnormal Structure of the Sarcoplasmatic Reticulum but Does Not Impair Skeletal Muscle Function

(2014) Tatiana Zyryanova et al.   PLoS One

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates

(2014) N. Hamoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond

(2014) Jason R. Stephenson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Progress in demystification of adhesion G protein-coupled receptors

(2013) Ines Liebscher et al.   BIOLOGICAL CHEMISTRY

Leukemia surfaceome analysis reveals new disease-associated features

(2013) P. Mirkowska et al.   BLOOD

A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis

(2013) Massimo Masiero et al.   CANCER CELL

GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G q-p63RhoGEF-Rho GTPase Pathway

(2013) X. Tang et al.   CANCER RESEARCH

The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

(2013) M. Kaucka et al.   CANCER RESEARCH

Physical Urticarias and Cholinergic Urticaria

(2013) Marina Abajian et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42

(2013) Nadejda Valtcheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Cadherins Celsr1-3 Differentially Regulate Migration of Facial Branchiomotor Neurons in Mice

(2013) Y. Qu et al.   JOURNAL OF NEUROSCIENCE

Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation

(2013) A. Mogha et al.   JOURNAL OF NEUROSCIENCE

G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1

(2013) Günther HS Richter et al.   JOURNAL OF PATHOLOGY

Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56

(2013) Y Saito et al.   LEUKEMIA

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis

(2013) Ikuyo Kou et al.   NATURE GENETICS

Overexpression of CD97 Confers an Invasive Phenotype in Glioblastoma Cells and Is Associated with Decreased Survival of Glioblastoma Patients

(2013) Michael Safaee et al.   PLoS One

Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via G s/G q-mediated protein kinases A/C

(2013) D. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

(2013) C. Patra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

Refining psychiatric phenotypes for response to treatment: Contribution of LPHN3 in ADHD

(2012) Aurelie Labbe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis

(2012) Redouane Allache et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse

(2012) Simone Prömel et al.   DEVELOPMENTAL DYNAMICS

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Signaling property study of adhesion G-protein-coupled receptors

(2012) Jamila Gupte et al.   FEBS LETTERS

Adipose tissue deletion ofGpr116impairs insulin sensitivity through modulation of adipose function

(2012) Tao Nie et al.   FEBS LETTERS

Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast

(2012) Shaoxi Liao et al.   GENES CHROMOSOMES & CANCER

LPHN3 and attention-deficit/hyperactivity disorder: interaction with maternal stress during pregnancy

(2012) Zia Choudhry et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Gene expression pattern contributing to prognostic factors in childhood acute lymphoblastic leukemia

(2012) Vanessa S. Silveira et al.   LEUKEMIA & LYMPHOMA

A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers

(2012) Francesco Bonardi et al.   MOLECULAR & CELLULAR PROTEOMICS

ELTD1, a Potential New Biomarker for Gliomas

(2012) Rheal A. Towner et al.   NEUROSURGERY

The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi

(2012) Arunkumar Krishnan et al.   PLoS One

Disease-Associated Mutations Prevent GPR56-Collagen III Interaction

(2012) Rong Luo et al.   PLoS One

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

(2012) Cedric Cortijo et al.   Cell Reports

New markers for minimal residual disease detection in acute lymphoblastic leukemia

(2011) E. Coustan-Smith et al.   BLOOD

Behind the scenes of non-nodal MCL: downmodulation of genes involved in actin cytoskeleton organization, cell projection, cell adhesion, tumour invasion, TP53 pathway and mutated status of immunoglobulin heavy chain genes

(2011) Ilaria Del Giudice et al.   BRITISH JOURNAL OF HAEMATOLOGY

LPA Receptor Heterodimerizes with CD97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells

(2011) Y. Ward et al.   CANCER RESEARCH

Non-USH2A mutations in USH2 patients

(2011) Thomas Besnard et al.   HUMAN MUTATION

Gene expression signatures differentiate adenocarcinoma of lung and breast origin in effusions

(2011) Ben Davidson et al.   HUMAN PATHOLOGY

Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma

(2011) Ole Ammerpohl et al.   INTERNATIONAL JOURNAL OF CANCER

Thy-1 (CD90) Is an Interacting Partner for CD97 on Activated Endothelial Cells

(2011) E. Wandel et al.   JOURNAL OF IMMUNOLOGY

Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastoma

(2011) Martin J. Rutkowski et al.   JOURNAL OF NEURO-ONCOLOGY

Independent HHsearch, Needleman-Wunsch-Based, and Motif Analyses Reveal the Overall Hierarchy for Most of the G Protein-Coupled Receptor Families

(2011) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities

(2011) J.-P. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

(2011) R. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer

(2010) Amy M Lum et al.   BMC CANCER

GPR56-related bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone complex

(2010) Nadia Bahi-Buisson et al.   BRAIN

Clinical Significance of GPR56, Transglutaminase 2, and NF-κB in Esophageal Squamous Cell Carcinoma

(2010) Tasneem Kausar et al.   CANCER INVESTIGATION

GPR56 is essential for testis development and male fertility in mice

(2010) Guangchun Chen et al.   DEVELOPMENTAL DYNAMICS

Genotype–phenotype relationship in three cases with overlapping 19p13.12 microdeletions

(2010) Maria C Bonaglia et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

(2010) M Arcos-Burgos et al.   MOLECULAR PSYCHIATRY

Planar polarization of node cells determines the rotational axis of node cilia

(2010) Masakazu Hashimoto et al.   NATURE CELL BIOLOGY

Overexpression of CD97 in Intestinal Epithelial Cells of Transgenic Mice Attenuates Colitis by Strengthening Adherens Junctions

(2010) Susann Becker et al.   PLoS One

Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis

(2010) Dragana Antic et al.   PLoS One

The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse

(2010) Helen Waller-Evans et al.   PLoS One

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review)

(2009) Katoh   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Arthrogryposis: A Review and Update

(2009) Michael Bamshad et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Therapeutic Antibody Targeting of CD97 in Experimental Arthritis: the Role of Antigen Expression, Shedding, and Internalization on the Pharmacokinetics of Anti-CD97 Monoclonal Antibody 1B2

(2009) D. M. de Groot et al.   JOURNAL OF IMMUNOLOGY

GPR56-Regulated Granule Cell Adhesion Is Essential for Rostral Cerebellar Development

(2009) S. Koirala et al.   JOURNAL OF NEUROSCIENCE

Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size

(2009) Nicole Soranzo et al.   PLoS Genetics

Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat

(2008) Tatjana Haitina et al.   BMC NEUROSCIENCE

Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway

(2008) Tokuichi Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas

(2008) Justyna Leja et al.   MODERN PATHOLOGY

The Secretin GPCRs Descended from the Family of Adhesion GPCRs

(2008) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

The developmental genetics of congenital heart disease

(2008) Benoit G. Bruneau   NATURE

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles

(2008) Danelle Devenport et al.   NATURE CELL BIOLOGY

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

HE6/GPR64 adhesion receptor co-localizes with apical and subapical F-actin scaffold in male excurrent duct epithelia

(2008) Christiane Kirchhoff et al.   REPRODUCTION

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function

(2007) Simon Yona et al.   FASEB JOURNAL