From Drosophila segmentation to human cancer therapy

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

(2018) Eamon FX Byrne et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt signalling: conquering complexity

(2018) Katrin E. Wiese et al.   DEVELOPMENT

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

(2017) Ashley E. Ross et al.   Oncotarget

ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation

(2016) Patrick Y. Lang et al.   DEVELOPMENT

A phase I trial of the Hedgehog inhibitor, sonidegib (LDE225), in combination with etoposide and cisplatin for the initial treatment of extensive stage small cell lung cancer

(2016) M. Catherine Pietanza et al.   LUNG CANCER

I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs

(2016) James K. Chen   NATURAL PRODUCT REPORTS

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

(2014) J. Rodon et al.   CLINICAL CANCER RESEARCH

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

(2010) Shifeng Pan et al.   ACS Medicinal Chemistry Letters

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

(2009) Bo Gao et al.   NATURE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT