Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

(2016) C. Pabst et al.   BLOOD

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations

(2014) Vincent-Philippe Lavallée et al.   BLOOD

Novel insights into G protein and G protein-coupled receptor signaling in cancer

(2014) Morgan O’Hayre et al.   CURRENT OPINION IN CELL BIOLOGY

Purinergic P2Y14 receptor modulates stress-induced hematopoietic stem/progenitor cell senescence

(2014) Joonseok Cho et al.   JOURNAL OF CLINICAL INVESTIGATION

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets

(2014) Marie Fève et al.   PLoS One

Proteinase-Activated Receptor 1 (PAR1) Regulates Leukemic Stem Cell Functions

(2014) Nicole Bäumer et al.   PLoS One

P2Y2 receptor promotes cell invasion and metastasis in prostate cancer cells

(2013) W-H Li et al.   BRITISH JOURNAL OF CANCER

The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival

(2013) S. Elangovan et al.   CANCER RESEARCH

U.S. Food and Drug Administration Approval: Vismodegib for Recurrent, Locally Advanced, or Metastatic Basal Cell Carcinoma

(2013) M. Axelson et al.   CLINICAL CANCER RESEARCH

Recent developments in biased agonism

(2013) James W Wisler et al.   CURRENT OPINION IN CELL BIOLOGY

Hedgehog Signaling Pathway and Cancer Therapeutics: Progress to Date

(2013) Joshua M. Ruch et al.   DRUGS

Unraveling the structural basis of GPCR activation and inactivation

(2013) Michel Bouvier   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

RNA-Seq Reveals Spliceosome and Proteasome Genes as Most Consistent Transcripts in Human Cancer Cells

(2013) Tara MacRae et al.   PLoS One

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of CXCR4 in the Pathogenesis of Acute Myeloid Leukemia

(2013) Amnon Peled et al.   Theranostics

Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial

(2012) Paul P Tak et al.   ANNALS OF THE RHEUMATIC DISEASES

Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines

(2012) Angélica Dutra-Oliveira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

(2012) G. L. Uy et al.   BLOOD

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

(2012) D. J. Dairaghi et al.   BLOOD

CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model

(2012) Y Ward et al.   ONCOGENE

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor

(2011) Chiara Carnini et al.   FASEB JOURNAL

A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment

(2011) E Ferretti et al.   LEUKEMIA

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Nicotinic Acid Receptor Abnormalities in Human Skin Cancer: Implications for a Role in Epidermal Differentiation

(2011) Yira Bermudez et al.   PLoS One

RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity

(2010) B. T. Wilhelm et al.   BLOOD

Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptor

(2010) F Wunder et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cysteinyl leukotriene receptor expression pattern affects migration of breast cancer cells and survival of breast cancer patients

(2010) Cecilia Magnusson et al.   INTERNATIONAL JOURNAL OF CANCER

Differential Signaling of Cysteinyl Leukotrienes and a Novel Cysteinyl Leukotriene Receptor 2 (CysLT2) Agonist, N-Methyl-Leukotriene C4, in Calcium Reporter and   Arrestin Assays

(2010) D. Yan et al.   MOLECULAR PHARMACOLOGY

Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2

(2010) Zhou   ONCOLOGY REPORTS

Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

(2009) J. Hoggatt et al.   BLOOD

Defective engraftment of C3aR−/− hematopoietic stem progenitor cells shows a novel role of the C3a–C3aR axis in bone marrow homing

(2009) M Wysoczynski et al.   LEUKEMIA

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD