Applications of biomaterials for immunosuppression in tissue repair and regeneration

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

(2021) Ashley J. Russo et al.   NATURE IMMUNOLOGY

Sequential Delivery of Cryogel Released Growth Factors and Cytokines Accelerates Wound Healing and Improves Tissue Regeneration

(2020) Shiro Jimi et al.   Frontiers in Bioengineering and Biotechnology

Apoptotic Cell–Directed Resolution of Lung Inflammation Requires Myeloid αv Integrin–Mediated Induction of Regulatory T Lymphocytes

(2020) Ailiang Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin

(2020) Jeremy Di Domizio et al.   NATURE IMMUNOLOGY

Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant

(2020) Laura L. McIntyre et al.   NEUROBIOLOGY OF DISEASE

Alginate/laponite hydrogel microspheres co-encapsulating dental pulp stem cells and VEGF for endodontic regeneration

(2020) Ruitao Zhang et al.   Acta Biomaterialia

IL ‐10 producing type 2 innate lymphoid cells prolong islet allograft survival

(2020) Qingsong Huang et al.   EMBO Molecular Medicine

Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage

(2020) Ruth A. Houseright et al.   Scientific Reports

B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

(2020) Masashi Watanabe et al.   Nature Communications

Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death

(2020) K. Hayashi et al.   Nature Communications

MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting odontogenesis

(2020) Jianmao Zheng et al.   Stem Cell Research & Therapy

Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors

(2019) Laura Saldaña et al.   Stem Cell Research & Therapy

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

(2019) Nisarg J. Shah et al.   NATURE BIOTECHNOLOGY

Innate Control of Tissue-Reparative Human Regulatory T Cells

(2019) Avery J. Lam et al.   JOURNAL OF IMMUNOLOGY

Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

(2019) Anubhav N. Mathur et al.   IMMUNITY

G-CSF-induced macrophage polarization and mobilization may prevent acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

(2019) Qi Wen et al.   BONE MARROW TRANSPLANTATION

A new class of biological materials: Cell membrane-derived hydrogel scaffolds

(2019) Zhiyuan Fan et al.   BIOMATERIALS

Material stiffness influences the polarization state, function and migration mode of macrophages

(2019) Rukmani Sridharan et al.   Acta Biomaterialia

Coacervate-mediated exogenous growth factor delivery for scarless skin regeneration

(2019) Uiseon Park et al.   Acta Biomaterialia

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

(2019) Shipin Zhang et al.   BIOMATERIALS

CTHRC1 promotes wound repair by increasing M2 macrophages via regulating the TGF-β and notch pathways

(2019) Shu Qin et al.   BIOMEDICINE & PHARMACOTHERAPY

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

(2019) Stefan Uderhardt et al.   CELL

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction

(2019) Lisa Schmidleithner et al.   IMMUNITY

Regenerative Scar-Free Skin Wound Healing

(2019) Mehri Monavarian et al.   TISSUE ENGINEERING PART B-REVIEWS

Macroscale biomaterials strategies for local immunomodulation

(2019) Maxence O. Dellacherie et al.   Nature Reviews Materials

Regulation of the inflammatory response by vascular grafts modified with Aspirin-Triggered Resolvin D1 promotes blood vessel regeneration

(2019) Jie Shi et al.   Acta Biomaterialia

Localized delivery of immunosuppressive regulatory T cells to peripheral nerve allografts promotes regeneration of branched segmental defects

(2019) Kelly C. Santos Roballo et al.   BIOMATERIALS

Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA‐Laden Nanoparticles Promotes Wound Healing

(2019) Bahram Saleh et al.   Small

Glucocorticoids Shape Macrophage Phenotype for Tissue Repair

(2019) Thibaut Desgeorges et al.   Frontiers in Immunology

Biomimetic anti-inflammatory nano-capsule serves as a cytokine blocker and M2 polarization inducer for bone tissue repair

(2019) Chengcheng Yin et al.   Acta Biomaterialia

Hierarchical microchanneled scaffolds modulate multiple tissue-regenerative processes of immune-responses, angiogenesis, and stem cell homing

(2019) Jong-Eun Won et al.   BIOMATERIALS

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

(2019) Jennifer Schnieder et al.   MATRIX BIOLOGY

Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus

(2018) Zhiai Hu et al.   ACS Applied Materials & Interfaces

Keratin biomaterials augment anti-inflammatory macrophage phenotype in vitro

(2018) Michele Waters et al.   Acta Biomaterialia

Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomers

(2018) V. Bonito et al.   Acta Biomaterialia

3D-printed IFN-γ-loading calcium silicate-β-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone

(2018) Tao Li et al.   Acta Biomaterialia

Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration

(2018) Yan Huang et al.   Acta Biomaterialia

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD4 T-cells regulate angiogenesis and myogenesis

(2018) Brian J. Kwee et al.   BIOMATERIALS

Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes

(2018) Fujian Zhao et al.   BIOMATERIALS

Mesenchymal stem cell-macrophage crosstalk and bone healing

(2018) Jukka Pajarinen et al.   BIOMATERIALS

Macrophage phenotype switch by sequential action of immunomodulatory cytokines from hydrogel layers on titania nanotubes

(2018) Junhong Chen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile

(2018) Waleed H. Mahallawi et al.   CYTOKINE

Intrahepatic T cell receptor β immune repertoire is essential for liver regeneration

(2018) Qing Liang et al.   HEPATOLOGY

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dual-delivery of VEGF and NGF by emulsion electrospun nanofibrous scaffold for peripheral nerve regeneration

(2018) Bin Xia et al.   Materials Science & Engineering C-Materials for Biological Applications

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

(2018) David Zemmour et al.   NATURE IMMUNOLOGY

Tregcells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration

(2018) Marisella Panduro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated dendritic cells modulate proliferation and differentiation of human myoblasts

(2018) Leandro Ladislau et al.   Cell Death & Disease

Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype

(2018) Xinyu Qiu et al.   Stem Cell Research & Therapy

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

(2018) Stella Cosenza et al.   Theranostics

Accelerated host angiogenesis and immune responses by ion release from mesoporous bioactive glass

(2018) Yinghong Zhou et al.   Journal of Materials Chemistry B

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

(2018) Kati Hyvärinen et al.   Frontiers in Immunology

Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo

(2018) Clémence Roux et al.   Frontiers in Immunology

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation

(2018) Kristin Freudenberg et al.   Frontiers in Immunology

Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

(2018) Jiatao Li et al.   Frontiers in Immunology

Tissue repair and regeneration with endogenous stem cells

(2018) Huimin Xia et al.   Nature Reviews Materials

Nanofibrous Spongy Microspheres To Distinctly Release miRNA and Growth Factors To Enrich Regulatory T Cells and Rescue Periodontal Bone Loss

(2018) Zhongning Liu et al.   ACS Nano

Macrophage response to hydrophilic biomaterials regulates MSC recruitment and T-helper cell populations

(2018) Kelly M. Hotchkiss et al.   BIOMATERIALS

Immunomodulatory injectable silk hydrogels maintaining functional islets and promoting anti-inflammatory M2 macrophage polarization

(2018) Manishekhar Kumar et al.   BIOMATERIALS

Bioceramics to regulate stem cells and their microenvironment for tissue regeneration

(2018) Yanling Zhou et al.   Materials Today

Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727

(2018) Nathan Robertson et al.   NATURE

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

(2018) Catherine A. Loynes et al.   Science Advances

Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes

(2018) Yachao Jia et al.   Acta Biomaterialia

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury

(2018) Jonghyuck Park et al.   JOURNAL OF CONTROLLED RELEASE

M2b macrophage polarization and its roles in diseases

(2018) Le-xun Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS

(2018) Linxiao Wu et al.   Acta Biomaterialia

Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis

(2017) Wen Sun et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration

(2017) M. Takewaki et al.   JOURNAL OF DENTAL RESEARCH

IL-4/IL-13–mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury

(2017) Ming-Zhi Zhang et al.   KIDNEY INTERNATIONAL

Pro-inflammatory M1 macrophage enhances metastatic potential of ovarian cancer cells through NF-κB activation

(2017) Untack Cho et al.   MOLECULAR CARCINOGENESIS

Extra-Large Pore Mesoporous Silica Nanoparticles for Directing in Vivo M2 Macrophage Polarization by Delivering IL-4

(2017) Dohyeong Kwon et al.   NANO LETTERS

Nanoporous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages

(2017) Zetao Chen et al.   Nanoscale

Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates

(2017) Joshua C. Doloff et al.   NATURE MATERIALS

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

(2017) Jenna L. Dziki et al.   TISSUE ENGINEERING PART A

Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair

(2017) Feini Qu et al.   Nature Communications

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

(2017) Daniele C. Nascimento et al.   Nature Communications

Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells

(2017) Xin Dong et al.   Journal of Materials Chemistry B

Neutrophils at the Biological–Material Interface

(2017) Siddharth Jhunjhunwala   ACS Biomaterials-Science & Engineering

Neutrophils at the Biological–Material Interface

(2017) Siddharth Jhunjhunwala   ACS Biomaterials Science & Engineering

Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury

(2017) Claire E. Olingy et al.   Scientific Reports

Dendritic Cell-derived Extracellular Vesicles mediate Mesenchymal Stem/Stromal Cell recruitment

(2017) Andreia M. Silva et al.   Scientific Reports

Strategies for MSC expansion and MSC-based microtissue for bone regeneration

(2017) Varitsara Bunpetch et al.   BIOMATERIALS

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury

(2016) Christopher L. Dearth et al.   Acta Biomaterialia

Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis

(2016) Mengchao Shi et al.   Acta Biomaterialia

Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings

(2016) Helena Knopf-Marques et al.   BIOMACROMOLECULES

Carboxyl- and amino-functionalized polystyrene nanoparticles differentially affect the polarization profile of M1 and M2 macrophage subsets

(2016) Ann-Kathrin Fuchs et al.   BIOMATERIALS

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

The impact of surface chemistry modification on macrophage polarisation

(2016) Hassan M. Rostam et al.   IMMUNOBIOLOGY

Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation

(2016) Xiao-qin Wu et al.   IMMUNOLOGY

Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype

(2016) Jenna L. Dziki et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

(2016) Irina A. Leaf et al.   JOURNAL OF CLINICAL INVESTIGATION

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

(2016) Mario Moisés Alvarez et al.   JOURNAL OF CONTROLLED RELEASE

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia

(2016) Somayyeh Hamzei Taj et al.   Journal of Neuroimmune Pharmacology

Osteoimmunomodulation for the development of advanced bone biomaterials

(2016) Zetao Chen et al.   Materials Today

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

Matrix-bound nanovesicles within ECM bioscaffolds

(2016) L. Huleihel et al.   Science Advances

Biomaterial Strategies for Immunomodulation

(2015) Nathan A. Hotaling et al.   Annual Review of Biomedical Engineering

Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis

(2015) Shardool Jain et al.   BIOMATERIALS

Modulation of the inflammatory response to chitosan through M2 macrophage polarization using pro-resolution mediators

(2015) Daniela P. Vasconcelos et al.   BIOMATERIALS

Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells

(2015) Michael D. McHugh et al.   BIOMATERIALS

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

(2015) Kara L. Spiller et al.   BIOMATERIALS

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

(2015) Omid Veiseh et al.   NATURE MATERIALS

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Systemic Infusion of Mesenchymal Stem Cells Improves Cell-Based Bone Regeneration via Upregulation of Regulatory T Cells

(2015) Yi Liu et al.   TISSUE ENGINEERING PART A

Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners

(2015) Hong Lei et al.   Frontiers in Pharmacology

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions

(2015) Hanna Siiskonen et al.   Frontiers in Immunology

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration

(2015) Alessandra Castiglioni et al.   PLoS One

An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits

(2014) Wei Wang et al.   Acta Biomaterialia

Mesenchymal stroma cells trigger early attraction of M1 macrophages and endothelial cells into fibrin hydrogels, stimulating long bone healing without long-term engraftment

(2014) Elisabeth Seebach et al.   Acta Biomaterialia

The promotion of a constructive macrophage phenotype by solubilized extracellular matrix

(2014) Brian M. Sicari et al.   BIOMATERIALS

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

(2014) Johannes Weirather et al.   CIRCULATION RESEARCH

Phenotype and polarization of autologous T cells by biomaterial-treated dendritic cells

(2014) Jaehyung Park et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

CD8 T Cells Are Involved in Skeletal Muscle Regeneration through Facilitating MCP-1 Secretion and Gr1highMacrophage Infiltration

(2014) Jing Zhang et al.   JOURNAL OF IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors

(2014) Surya Pandey et al.   Cold Spring Harbor Perspectives in Biology

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

(2013) Koyal Garg et al.   BIOMATERIALS

Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression

(2013) R. Michael Gower et al.   BIOMATERIALS

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Macrophages: Supportive cells for tissue repair and regeneration

(2013) Bénédicte Chazaud   IMMUNOBIOLOGY

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans

(2013) S. Reinke et al.   Science Translational Medicine

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials

(2011) Bryan N. Brown et al.   Acta Biomaterialia

Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold

(2011) Carolyn A. Holladay et al.   BIOMATERIALS

Consequences of ineffective decellularization of biologic scaffolds on the host response

(2011) Timothy J. Keane et al.   BIOMATERIALS

Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α

(2011) Yi Liu et al.   NATURE MEDICINE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages

(2010) Qingshan Wang et al.   CELL RESEARCH

IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia

(2010) Wei-Kang Wu et al.   IMMUNOBIOLOGY

Phenotypic and functional switch of macrophages induced by regulatory CD4+ CD25+ T cells in mice

(2010) Guangwei Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Effect of polyurethane chemistry and protein coating on monocyte differentiation towards a wound healing phenotype macrophage

(2009) Joanne E. McBane et al.   BIOMATERIALS

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

(2009) Franco R. D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular matrix as a biological scaffold material: Structure and function

(2008) S BADYLAK et al.   Acta Biomaterialia

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Macrophage activation by endogenous danger signals

(2007) X Zhang et al.   JOURNAL OF PATHOLOGY