Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

Review of phase III trial data on IL-23 inhibitors tildrakizumab and guselkumab for psoriasis

(2017) M. Amin et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Current and emerging therapeutic targets for IBD

(2017) Markus F. Neurath   Nature Reviews Gastroenterology & Hepatology

Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2

(2017) Justine Newson et al.   Cell Reports

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization

(2017) Claudia Lo Sicco et al.   Stem Cells Translational Medicine

IL-23 and Th17 Disease in Inflammatory Arthritis

(2017) et al.   Journal of Clinical Medicine

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators*

(2016) Konstantin Tsoyi et al.   CRITICAL CARE MEDICINE

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Adenosinergic Immunosuppression by Human Mesenchymal Stromal Cells Requires Co-Operation with T cells

(2016) Erja Kerkelä et al.   STEM CELLS

Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses

(2016) Laura Chiossone et al.   STEM CELLS

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

(2016) Megan V. Jackson et al.   STEM CELLS

Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions

(2016) Mariano Di Trapani et al.   Scientific Reports

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

(2016) Anoop Babu Vasandan et al.   Scientific Reports

Therapeutic Effects of Human Mesenchymal Stem Cell–derived Microvesicles in Severe Pneumonia in Mice

(2015) Antoine Monsel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4

(2015) Xiaohui Fang et al.   JOURNAL OF IMMUNOLOGY

The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling

(2015) Bryan D. Fleming et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

Bone Marrow-Derived Mesenchymal Stromal Cells Harness Purinergenic Signaling to Tolerize Human Th1 Cells In Vivo

(2015) Shoba Amarnath et al.   STEM CELLS

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Resolution phase lipid mediators of inflammation: agonists of resolution

(2013) Charles N. Serhan et al.   CURRENT OPINION IN PHARMACOLOGY

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

LC–MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites

(2013) Pauline Le Faouder et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

PGE2 differentially regulates monocyte-derived dendritic cell cytokine responses depending on receptor usage (EP2/EP4)

(2013) Neil J. Poloso et al.   MOLECULAR IMMUNOLOGY

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation

(2012) Christiane Broichhausen et al.   Current Opinion in Organ Transplantation

Mechanisms of mesenchymal stromal cell immunomodulation

(2012) Karen English   IMMUNOLOGY AND CELL BIOLOGY

Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IL-10-Dependent Regulatory Dendritic Cells by SOCS3 Activation

(2012) X. Liu et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 and Aspirin-Triggered Resolvin D1 Promote Resolution of Allergic Airways Responses

(2012) A. P. Rogerio et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit

(2012) Khalid W. Kalim et al.   MOLECULAR IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype

(2012) Joni H. YlÖstalo et al.   STEM CELLS

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

(2011) J. A. Hutchinson et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes

(2011) Felipe Saldanha-Araujo et al.   Stem Cell Research

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

(2009) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Bone marrow mesenchymal stem cells undergo nemosis and induce keratinocyte wound healing utilizing the HGF/c-Met/PI3K pathway

(2009) Matti Peura et al.   WOUND REPAIR AND REGENERATION

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

(2008) Oliver Haworth et al.   NATURE IMMUNOLOGY

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE