Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion

The cell-permeable mitochondrial calcium uniporter inhibitor Ru265 preserves cortical neuron respiration after lethal oxygen glucose deprivation and reduces hypoxic/ischemic brain injury

(2020) Robyn J Novorolsky et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deletion of a neuronal Drp1 activator protects against cerebral ischemia

(2020) Kyle H. Flippo et al.   JOURNAL OF NEUROSCIENCE

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

(2020) Natalia Moskal et al.   Nature Communications

Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery

(2020) Mija Marinković et al.   Autophagy

Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways

(2020) Chenyang Duan et al.   Cell Death & Disease

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

(2020) Yangxin Li et al.   Frontiers in Pharmacology

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

(2020) Yongxing Lai et al.   Redox Biology

Mitophagy in Cardiovascular Diseases

(2020) Giampaolo Morciano et al.   Journal of Clinical Medicine

Mechanism of succinate efflux upon reperfusion of the ischemic heart

(2020) Hiran A Prag et al.   CARDIOVASCULAR RESEARCH

Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1

(2020) Nancy Tseng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

(2020) Massimo Bonora et al.   Biomolecules

The Dichotomous Role of Inflammation in the CNS: A Mitochondrial Point of View

(2020) Bianca Vezzani et al.   Biomolecules

Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes

(2019) Wai Ping Yew et al.   Journal of Neuroinflammation

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke

(2019) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

(2019) Henry Ma et al.   NEW ENGLAND JOURNAL OF MEDICINE

IMM-H004 Therapy for Permanent Focal Ischemic Cerebral Injury via CKLF1/CCR4-mediated NLRP3 Inflammasome Activation

(2019) QI-DI AI et al.   Translational Research

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins

(2019) Anatoly B. Uzdensky   APOPTOSIS

NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice

(2019) Haining Wang et al.   LIFE SCIENCES

Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

(2019) He et al.   Cells

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis

(2019) Yi Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Highlight article: The brain and eye: Treating cerebral and retinal ischemia through mitochondrial transfer

(2019) Matt Heyck et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mitochondria as a therapeutic target for ischemic stroke

(2019) Zhi He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ischemic stroke and mitochondria: mechanisms and targets

(2019) Syed Suhail Andrabi et al.   PROTOPLASMA

Neuroprotection by mesenchymal stem cell (MSC) administration is enhanced by local cooling infusion (LCI) in ischemia

(2019) Wenjing Wei et al.   BRAIN RESEARCH

URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

(2019) Shao-Hua Su et al.   Journal of Neuroinflammation

Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation

(2019) Zhihuai Mo et al.   LIFE SCIENCES

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion

(2018) Miki Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

(2018) Ruby Macdonald et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanical thrombectomy – is time still brain? The DAWN of a new era

(2018) Naveed Kamal et al.   BRITISH JOURNAL OF NEUROSURGERY

Mitofusin 2 Exerts a Protective Role in Ischemia Reperfusion Injury Through Increasing Autophagy

(2018) Cheng Peng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Time Is Brain: The Stroke Theory of Relativity

(2018) Camilo R. Gomez   Journal of Stroke & Cerebrovascular Diseases

Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery

(2018) Valentina Babenko et al.   MOLECULES

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

(2018) Gregory W. Albers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

(2018) Raul G. Nogueira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

DAWN and DEFUSE-3 trials: is time still important?

(2018) A. Ragoschke-Schumm et al.   RADIOLOGE

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Brief Reports: Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium

(2018) Kazuhide Hayakawa et al.   STEM CELLS

Eligibility for Endovascular Trial Enrollment in the 6- to 24-Hour Time Window

(2018) Ashutosh P. Jadhav et al.   STROKE

Protective Effects of Brain Infarction byN-Acetylcysteine Derivatives

(2018) Takeshi Uemura et al.   STROKE

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

Time Is Brain: The Stroke Theory of Relativity

(2018) Camilo R. Gomez   Journal of Stroke & Cerebrovascular Diseases

Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice

(2018) Pu Hong et al.   NEURAL PLASTICITY

Dynamin-Related Protein 1 at the Crossroads of Cancer

(2018) Ana Rita Lima et al.   Genes

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link

(2018) Jaime Ramos-Cejudo et al.   EBioMedicine

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

Publisher Correction: The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New insights into the complex role of mitochondria in Parkinson’s disease

(2018) Anne Grünewald et al.   PROGRESS IN NEUROBIOLOGY

Muscle-derived autologous mitochondrial transplantation: A novel strategy for treating cerebral ischemic injury

(2018) Zhanqin Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke

(2018) Maxime Gauberti et al.   STROKE

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

(2018) Nabila Boukelmoune et al.   Acta Neuropathologica Communications

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

(2017) Xinchun Ye et al.   EXPERIMENTAL NEUROLOGY

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

(2017) Yuan-Yuan Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders

(2017) Yajin Liao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy and mitophagy elements are increased in body fluids of multiple sclerosis-affected individuals

(2017) Simone Patergnani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

From Mitochondrial Function to Neuroprotection—an Emerging Role for Methylene Blue

(2017) Donovan Tucker et al.   MOLECULAR NEUROBIOLOGY

Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke

(2017) Stephanie M. Davis et al.   NEUROCHEMISTRY INTERNATIONAL

Reactive oxygen species trigger NF-κB-mediated NLRP3 inflammasome activation induced by zinc oxide nanoparticles in A549 cells

(2017) Xiao Liang et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

(2017) Shenglong Cao et al.   Scientific Reports

Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application

(2017) Shaohua Liao et al.   Stem Cells International

Desensitizing Mitochondrial Permeability Transition by ERK-Cyclophilin D Axis Contributes to the Neuroprotective Effect of Gallic Acid against Cerebral Ischemia/Reperfusion Injury

(2017) Jing Sun et al.   Frontiers in Pharmacology

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

(2017) Brice Nzigou Mombo et al.   Jove-Journal of Visualized Experiments

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats

(2016) Chenhui Li et al.   BRAIN BEHAVIOR AND IMMUNITY

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Transferring Xenogenic Mitochondria Provides Neural Protection against Ischemic Stress in Ischemic Rat Brains

(2016) Po-Jui Huang et al.   CELL TRANSPLANTATION

Reversible Disruption of Neuronal Mitochondria by Ischemic and Traumatic Injury Revealed by Quantitative Two-Photon Imaging in the Neocortex of Anesthetized Mice

(2016) Mikhail Kislin et al.   JOURNAL OF NEUROSCIENCE

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

(2016) Mayank Goyal et al.   LANCET

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke

(2016) Yunnan Lu et al.   NEUROIMMUNOMODULATION

Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via the inhibition of excessive mitophagy

(2016) Shoushui Yu et al.   NEUROSCIENCE LETTERS

Risk factors and subtypes of acute ischemic stroke. A study at King Fahd Hospital of the University

(2016) Azra Zafar et al.   Neurosciences

Parkin and mitophagy in cancer

(2016) J P Bernardini et al.   ONCOGENE

Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung

(2016) Kenneth Andrew Sinclair et al.   Stem Cell Research & Therapy

Interferon‐β Modulates Inflammatory Response in Cerebral Ischemia

(2016) Ping‐Chang Kuo et al.   Journal of the American Heart Association

MiR-25 Protects Cardiomyocytes against Oxidative Damage by Targeting the Mitochondrial Calcium Uniporter

(2015) Lei Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

(2015) Giampaolo Morciano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Unknown

(2015) Yao Di et al.   MOLECULAR MEDICINE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

A giant molecular proton pump: structure and mechanism of respiratory complex I

(2015) Leonid A. Sazanov   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain

(2015) Leoni Lammerding et al.   NEUROENDOCRINOLOGY

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke

(2015) Tudor G. Jovin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

(2015) Jeffrey L. Saver et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

(2015) Bruce C.V. Campbell et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

(2015) Olvert A. Berkhemer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Caspase-3 inhibitor prevents the apoptosis of brain tissue in rats with acute cerebral infarction

(2015) YUHUA SUN et al.   Experimental and Therapeutic Medicine

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Improving the Post-Stroke Therapeutic Potency of Mesenchymal Multipotent Stromal Cells by Cocultivation With Cortical Neurons: The Role of Crosstalk Between Cells

(2015) Valentina A. Babenko et al.   Stem Cells Translational Medicine

Circulating Endothelial Progenitor Cells and the Risk of Vascular Events after Ischemic Stroke

(2015) Joan Martí-Fàbregas et al.   PLoS One

An open-label evaluator-blinded clinical study of minocycline neuroprotection in ischemic stroke: gender-dependent effect

(2014) Mohammad Reza Amiri-Nikpour et al.   ACTA NEUROLOGICA SCANDINAVICA

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke

(2014) Ruo-Yang Shi et al.   CNS Neuroscience & Therapeutics

Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1

(2014) Yan-Xin Zhao et al.   CNS Neuroscience & Therapeutics

Intermittent fasting attenuates inflammasome activity in ischemic stroke

(2014) David Yang-Wei Fann et al.   EXPERIMENTAL NEUROLOGY

Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

(2014) Li Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial dynamics: cell-type and hippocampal region specific changes following global cerebral ischemia

(2014) Katrina Owens et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

Mobilization of Endogenous Bone Marrow Derived Endothelial Progenitor Cells and Therapeutic Potential of Parathyroid Hormone after Ischemic Stroke in Mice

(2014) Li-Li Wang et al.   PLoS One

Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1

(2014) Itsasne Bustillo-Zabalbeitia et al.   PLoS One

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

(2014) Seung-Hoon Baek et al.   STROKE

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of dynamin-related protein 1 in cancer growth: a promising therapeutic target?

(2013) Wei Qian et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

The role of the mitochondrial calcium uniporter in cerebral ischemia/reperfusion injury in rats involves regulation of mitochondrial energy metabolism

(2013) QIN ZHAO et al.   Molecular Medicine Reports

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Mechanisms of Glutamate Transport

(2013) Robert J. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Mitochondrial Dysfunction and NAD+ Metabolism Alterations in the Pathophysiology of Acute Brain Injury

(2013) Katrina Owens et al.   Translational Stroke Research

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Superoxide generation by complex III: From mechanistic rationales to functional consequences

(2012) Lea Bleier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Inhibition of Drp1 provides neuroprotection in vitro and in vivo

(2012) J Grohm et al.   CELL DEATH AND DIFFERENTIATION

Cell Therapy for Stroke: Emphasis on Optimizing Safety and Efficacy Profile of Endothelial Progenitor Cells

(2012) Yuji Kaneko et al.   CURRENT PHARMACEUTICAL DESIGN

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Pre- and Post-treatment with Cyclosporine a in a Rat Model of Transient Focal Cerebral Ischaemia with Multimodal MRI Screening

(2012) Tae-Hee Cho et al.   International Journal of Stroke

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

(2012) R. Anne Stetler et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice

(2012) Wentao Liu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation

(2012) Thomas H. Sanderson et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficacy of minocycline in acute ischemic stroke: A single-blinded, placebo-controlled trial

(2012) MV Padma Srivastava et al.   NEUROLOGY INDIA

Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases

(2012) Erwin W. Gelfand   NEW ENGLAND JOURNAL OF MEDICINE

Reperfusion Promotes Mitochondrial Dysfunction following Focal Cerebral Ischemia in Rats

(2012) Jun Li et al.   PLoS One

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes

(2011) Kangmin He et al.   CARDIOVASCULAR RESEARCH

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

(2011) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

In vivo Contributions of BH3-Only Proteins to Neuronal Death Following Seizures, Ischemia, and Traumatic Brain Injury

(2011) Tobias Engel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Preclinical Evaluation of Postischemic Dehydroascorbic Acid Administration in a Large-Animal Stroke Model

(2011) Andrew F. Ducruet et al.   Translational Stroke Research

High-Glucose Stimulation Increases Reactive Oxygen Species Production Through the Calcium and Mitogen-Activated Protein Kinase-Mediated Activation of Mitochondrial Fission

(2010) Tianzheng Yu et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial oxidant stress triggers cell death in simulated ischemia–reperfusion

(2010) Gabriel Loor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxygen Radicals in Focal Cerebral Ischemia

(2010) Pak H. Chan   BRAIN PATHOLOGY

Mitochondrial Ca2+ sequestration and precipitation revisited

(2010) Christos Chinopoulos et al.   FEBS Journal

Stem and progenitor cells for neurological repair: Minor issues, major hurdles, and exciting opportunities for paracrine-based therapeutics

(2010) Issei S. Shimada et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects against neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after tra

(2010) Shang-Der Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo

(2010) Xin Qi et al.   MOLECULAR BIOLOGY OF THE CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke

(2009) Junying Yuan   APOPTOSIS

Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia

(2009) Kuniyasu Niizuma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Targeting post-mitochondrial effectors of apoptosis for neuroprotection

(2008) Lorenzo Galluzzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia

(2008) Kentaro Toyama et al.   EXPERIMENTAL NEUROLOGY

Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture

(2008) E. Y. Plotnikov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EARLY-ONSET STROKE ASSOCIATED WITH A MUTATION IN MITOFUSIN 2

(2008) K. W. Chung et al.   NEUROLOGY

White Matter Thresholds for Ischemic Penumbra and Infarct Core in Patients with Acute Stroke: CT Perfusion Study

(2008) Blake D. Murphy et al.   RADIOLOGY

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

(2008) Wei Yin et al.   STROKE

Neuroprotection Does Not Work!

(2008) Joachim Röther   STROKE

Level and Value of Circulating Endothelial Progenitor Cells in Patients After Acute Ischemic Stroke

(2007) Hon-Kan Yip et al.   STROKE