The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders

Analysis of the structure and function of EMRE in a yeast expression system

(2016) Takenori Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7

(2016) M. Di Nottia et al.   CLINICAL GENETICS

Impact of aortic root size on left ventricular afterload and stroke volume

(2016) Anders Sahlén et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons inpink1−/−zebrafish

(2016) Smijin Soman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory profile in LRRK2-associated prodromal and clinical PD

(2016) Kathrin Brockmann et al.   Journal of Neuroinflammation

Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy

(2016) Chao Lin et al.   JOURNAL OF PINEAL RESEARCH

The m -AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

(2016) Tim König et al.   MOLECULAR CELL

Architecture of the mitochondrial calcium uniporter

(2016) Kirill Oxenoid et al.   NATURE

Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via the inhibition of excessive mitophagy

(2016) Shoushui Yu et al.   NEUROSCIENCE LETTERS

Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy

(2016) Holly J. Garringer et al.   PLoS One

Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop

(2016) Jinbo Cheng et al.   Scientific Reports

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non–Alzheimer Disease Pathophysiology

(2016) Brian A. Gordon et al.   JAMA Neurology

Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage

(2015) Huiying Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CCDC90A (MCUR1) Is a Cytochrome c Oxidase Assembly Factor and Not a Regulator of the Mitochondrial Calcium Uniporter

(2015) Vincent Paupe et al.   Cell Metabolism

Inflammation and neurodegenerative disorders

(2015) Bernhard T. Baune   CURRENT OPINION IN PSYCHIATRY

MiR-25 Protects Cardiomyocytes against Oxidative Damage by Targeting the Mitochondrial Calcium Uniporter

(2015) Lei Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

(2015) Dong Xian-hui et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis

(2015) Alessandro Rimessi et al.   Nature Communications

Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death

(2015) Yajin Liao et al.   Protein & Cell

Unresolved questions from the analysis of mice lacking MCU expression

(2014) Elizabeth Murphy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model

(2014) Clara Pereira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

High Plasma Glutamate Levels are Associated with Poor Functional Outcome in Acute Ischemic Stroke

(2014) Xiang-en Meng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake

(2014) L. Wang et al.   EMBO JOURNAL

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders

(2014) Pamela J. Urrutia et al.   Frontiers in Pharmacology

Intermittent hypoxia protects cerebral mitochondrial function from calcium overload

(2013) Jian Chen et al.   ACTA NEUROLOGICA BELGICA

Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload

(2013) J. Sripetchwandee et al.   Acta Physiologica

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Calcium dynamics during NMDA-induced membrane potential oscillations in lamprey spinal neurons - contribution of L-type calcium channels (CaV1.3)

(2013) Di Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload

(2013) Jirapas Sripetchwandee et al.   LIFE SCIENCES

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity

(2013) Katerina Melachroinou et al.   NEUROBIOLOGY OF AGING

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

Iron and ER stress in neurodegenerative disease

(2012) Yiting Liu et al.   BIOMETALS

The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis

(2012) Hyun Jeong Kim et al.   BRAIN

Brain iron accumulation in aging and neurodegenerative disorders

(2012) Jesper Hagemeier et al.   Expert Review of Neurotherapeutics

Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease

(2012) Jiu-Qiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional coupling of the metabotropic glutamate receptor, InsP3receptor and L-type Ca2+channel in mouse CA1 pyramidal cells

(2012) Hiroyuki K. Kato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Accumulation of Exogenous Amyloid-BetaPeptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

(2012) Sergio Rosales-Corral et al.   Oxidative Medicine and Cellular Longevity

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes

(2012) Felix Schmidt et al.   PLoS One

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress

(2011) Anna G. Barsukova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

(2011) Katherine C. M. Chew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis

(2011) Zhengxin Ying et al.   JOURNAL OF NEURAL TRANSMISSION

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: Mechanistic relationship and differential sensitivity to intervention

(2011) Miranda L. Tradewell et al.   NEUROBIOLOGY OF DISEASE

Further Evidence on Mitochondrial Targeting of β-Amyloid and Specificity of β-Amyloid-Induced Mitotoxicity in Neurons

(2011) Laurent Tillement et al.   Neurodegenerative Diseases

Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease

(2010) Clara Hiu-Ling Hung et al.   AGEING RESEARCH REVIEWS

Serum Calcium Levels and Long-Term Mortality in Patients with Acute Stroke

(2010) Shmuel A. Appel et al.   CEREBROVASCULAR DISEASES

Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family

(2010) Hemachand Tummala et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Calcium channel blockers and Parkinson disease

(2010) Ronald F. Pfeiffer   Nature Reviews Neurology

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glutamate, excitotoxicity, and programmed cell death in parkinson disease

(2009) W. Michael Caudle et al.   EXPERIMENTAL NEUROLOGY

In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012

(2009) Anders Kielland et al.   FREE RADICAL BIOLOGY AND MEDICINE

Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease

(2009) Ana Navarro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders

(2009) Nicholas P. Whitney et al.   JOURNAL OF NEUROCHEMISTRY

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux

(2009) Roberta Marongiu et al.   JOURNAL OF NEUROCHEMISTRY

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

(2009) Wencheng Liu et al.   PLoS One

Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death inTrypanosoma cruzi

(2008) Florencia Irigoín et al.   BIOCHEMICAL JOURNAL

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

(2008) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Calcium-Permeable AMPA Receptors Appear in Cortical Neurons after Traumatic Mechanical Injury and Contribute to Neuronal Fate

(2008) Jennifer M. Spaethling et al.   JOURNAL OF NEUROTRAUMA

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome drug candidate, decreased vulnerability of PC12 cells to human immunodeficiency virus tat protein through attenuating calcium overload

(2007) Bin Hui et al.   JOURNAL OF NEUROSCIENCE RESEARCH