NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Brain inflammasomes in stroke and depressive disorders: Regulation by oestrogen

(2018) A. Slowik et al.   JOURNAL OF NEUROENDOCRINOLOGY

Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors in rats following transient bilateral common carotid occlusion and reperfusion

(2018) Seyed Esmaeil Khoshnam et al.   METABOLIC BRAIN DISEASE

Transplantation of Human Umbilical Cord Blood Mononuclear Cells Attenuated Ischemic Injury in MCAO Rats via Inhibition of NF-κB and NLRP3 Inflammasome

(2018) Lu Liu et al.   NEUROSCIENCE

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

Endovascular Therapy in Ischemic Stroke With Acute Large‐Vessel Occlusion: Recovery by Endovascular Salvage for Cerebral Ultra‐Acute Embolism Japan Registry 2

(2018) Shinichi Yoshimura et al.   Journal of the American Heart Association

RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage

(2017) Keren Zhou et al.   EXPERIMENTAL NEUROLOGY

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

(2017) Xinchun Ye et al.   EXPERIMENTAL NEUROLOGY

Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion

(2017) Xiujian Xu et al.   INFLAMMATION RESEARCH

Amyloidogenic proteins associated with neurodegenerative diseases activate the NLRP3 inflammasome

(2017) Qian-hang Shao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

The Interplay of MicroRNAs in the Inflammatory Mechanisms Following Ischemic Stroke

(2017) Seyed Esmaeil Khoshnam et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats

(2017) Omid Karimi-Khouzani et al.   Pharmacological Reports

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

(2017) Jing Ji et al.   Frontiers in Cellular Neuroscience

A brief review: adipose-derived stem cells and their therapeutic potential in cardiovascular diseases

(2017) Teng Ma et al.   Stem Cell Research & Therapy

Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats

(2016) Chenhui Li et al.   BRAIN BEHAVIOR AND IMMUNITY

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

(2016) Jing Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes

(2016) Xiao-Feng Li et al.   JOINT BONE SPINE

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke

(2016) Yunnan Lu et al.   NEUROIMMUNOMODULATION

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds

(2016) Isabel Denzer et al.   PHARMACOLOGICAL RESEARCH

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

(2016) Manohar Salla et al.   ACS Medicinal Chemistry Letters

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation

(2015) S. Chen et al.   BLOOD

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

Inflammasome Inhibition: Putting Out the Fire

(2015) Mihai G. Netea et al.   Cell Metabolism

Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377

(2015) Wei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

(2015) Lucia de Almeida et al.   IMMUNITY

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

(2015) Justyna Rzepecka et al.   JOURNAL OF AUTOIMMUNITY

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

(2015) Andreas Hecker et al.   JOURNAL OF IMMUNOLOGY

Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia

(2015) Ana R. Inácio et al.   Journal of Neuroinflammation

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage

(2015) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model

(2015) Adib Zendedel et al.   MOLECULAR NEUROBIOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Perception of self: distinguishing autoimmunity from autoinflammation

(2015) Tessa S. van Kempen et al.   Nature Reviews Rheumatology

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain

(2015) Leoni Lammerding et al.   NEUROENDOCRINOLOGY

Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production

(2015) Li Wang et al.   NEUROSCIENCE LETTERS

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2

(2014) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1  Released from Dying Cells

(2014) T. Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

Interferon-beta confers protective effects against ischemic stroke through its anti-inflammatory properties

(2014) Ping-chang Kuo et al.   JOURNAL OF NEUROIMMUNOLOGY

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

Exploratory Analysis of Glyburide as a Novel Therapy for Preventing Brain Swelling

(2014) Kevin N. Sheth et al.   Neurocritical Care

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

(2014) John G Walsh et al.   Retrovirology

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Ketone body metabolism and cardiovascular disease

(2013) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

(2013) Qingyi Ma et al.   ANNALS OF NEUROLOGY

Functional Role of Soluble Receptor for Advanced Glycation End Products in Stroke

(2013) Sung-Chun Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2

(2013) Sayantani Bandyopadhyay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The role of interferon-β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis - in the perspective of inflammasomes

(2013) Makoto Inoue et al.   IMMUNOLOGY

Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation

(2013) Jijun Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

(2013) Nicolas Deroide et al.   JOURNAL OF CLINICAL INVESTIGATION

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

(2013) Marietta M. Budai et al.   MOLECULAR IMMUNOLOGY

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

(2013) Ming Lu et al.   NEUROBIOLOGY OF AGING

P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH

(2013) Sheng Chen et al.   NEUROBIOLOGY OF DISEASE

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Negative regulation of NLRP3 inflammasome signaling

(2013) Shuzhen Chen et al.   Protein & Cell

HMGB1 Promotes the Synthesis of Pro-IL-1β and Pro-IL-18 by Activation of p38 MAPK and NF-κB Through Receptors for Advanced Glycation End-products in Macrophages

(2012) Qiang He et al.   Asian Pacific Journal of Cancer Prevention

The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure

(2012) Thomas Maslanik et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP

(2012) Kuo-Chieh Liao et al.   INFECTION AND IMMUNITY

Nitric Oxide: Considerations for the Treatment of Ischemic Stroke

(2012) Nicole A Terpolilli et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

Redox control of NLRP3 inflammasome activation in health and disease

(2012) Anna Rubartelli   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

(2012) Süheda Erener et al.   MOLECULAR CELL

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

The Preventive and Therapeutic Effects of Intravenous Human Adipose-Derived Stem Cells in Alzheimer’s Disease Mice

(2012) Saeromi Kim et al.   PLoS One

Interferon-  Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome

(2012) M. Inoue et al.   Science Signaling

Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages

(2011) Oleg Lunov et al.   ACS Nano

Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats

(2011) Abedin Vakili et al.   BRAIN RESEARCH

Interleukin-1 and Stroke: Biomarker, Harbinger of Damage, and Therapeutic Target

(2011) Adam Denes et al.   CEREBROVASCULAR DISEASES

Interleukin-18, From Neuroinflammation to Alzheimers Disease

(2011) Paola Bossu et al.   CURRENT PHARMACEUTICAL DESIGN

Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: A retrospective examination

(2011) Daniel Keizman et al.   EUROPEAN JOURNAL OF CANCER

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine

(2010) Sarah L. Kempster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor suppressor death-associated protein kinase is required for full IL-1  production

(2010) Y.-T. Chuang et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolonged, 24-h Delayed Peripheral Inflammation Increases Short- and Long-Term Functional Impairment and Histopathological Damage after Focal Ischemia in the Rat

(2010) Kristopher D Langdon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

(2010) A. Denes et al.   JOURNAL OF NEUROSCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

Cutting Edge: Necrosis Activates the NLRP3 Inflammasome

(2009) H. Li et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation

(2009) Yajaira Suárez et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Interferon-  mechanisms of action in multiple sclerosis

(2009) S. Dhib-Jalbut et al.   NEUROLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

The HSP90-SGT1 Chaperone Complex for NLR Immune Sensors

(2008) Ken Shirasu   Annual Review of Plant Biology

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Evaluation of lactate as a marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA

(2008) Raf Brouns et al.   CLINICA CHIMICA ACTA

Control of protein synthesis and mRNA degradation by microRNAs

(2008) Jidong Liu   CURRENT OPINION IN CELL BIOLOGY

Post-ischemic brain damage: pathophysiology and role of inflammatory mediators

(2008) Diana Amantea et al.   FEBS Journal

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption after Experimental Stroke in Mice

(2008) B. W. McColl et al.   JOURNAL OF NEUROSCIENCE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Cell adhesion molecules and ischemic stroke

(2008) Gokhan Yilmaz et al.   NEUROLOGICAL RESEARCH

Electrophysiology of cerebral ischemia

(2008) Krešimir Krnjević   NEUROPHARMACOLOGY

NF-κB signaling in cerebral ischemia

(2008) D.A. Ridder et al.   NEUROSCIENCE

Evidence for a cytokine model of cognitive function

(2008) J. McAfoose et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Neutrophilia Is Associated With Volume of Ischemic Tissue in Acute Stroke

(2007) Brian H. Buck et al.   STROKE

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY