A giant molecular proton pump: structure and mechanism of respiratory complex I

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

The mechanism of coupling between electron transfer and proton translocation in respiratory complex I

(2014) Leonid A. Sazanov   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I

(2014) V. R. I. Kaila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidoreduction properties of bound ubiquinone in Complex I from Escherichia coli

(2013) Marina Verkhovskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Energy Transducing Roles of Antiporter-like Subunits inEscherichia coliNDH-1 with Main Focus on Subunit NuoN (ND2)

(2013) Motoaki Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A two-domain elevator mechanism for sodium/proton antiport

(2013) Chiara Lee et al.   NATURE

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Arginine oscillation explains Na+ independence in the substrate/product antiporter CaiT

(2013) S. Kalayil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of the binding-change mechanism for proton-translocating transhydrogenase

(2012) J. Baz Jackson   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The coupling mechanism of respiratory complex I — A structural and evolutionary perspective

(2012) Rouslan G. Efremov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Asp563 of the horizontal helix of subunit NuoL is involved in proton translocation by the respiratory complex I

(2012) Stefan Steimle et al.   FEBS LETTERS

Energy-converting respiratory Complex I: On the way to the molecular mechanism of the proton pump

(2012) Marina Verkhovskaya et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Deactive Form of Respiratory Complex I from Mammalian Mitochondria Is a Na+/H+Antiporter

(2012) Philippa G. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrangement of subunits in intact mammalian mitochondrial ATP synthase determined by cryo-EM

(2012) L. A. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

(2012) Arian Emami Riedmaier et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mössbauer Spectroscopy on Respiratory Complex I: The Iron–Sulfur Cluster Ensemble in the NADH-Reduced Enzyme Is Partially Oxidized

(2011) Hannah R. Bridges et al.   BIOCHEMISTRY

A two-state stabilization-change mechanism for proton-pumping complex I

(2011) Ulrich Brandt   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Respiratory complex I: ‘steam engine’ of the cell?

(2011) Rouslan G Efremov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Contribution of C-terminal Segments of NuoL (ND5) and NuoM (ND4) Subunits of Complex I fromEscherichia coli

(2011) Jesus Torres-Bacete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Evolution of Respiratory Chain Complex I from a Smaller Last Common Ancestor Consisting of 11 Protein Subunits

(2011) Vamsi K. Moparthi et al.   JOURNAL OF MOLECULAR EVOLUTION

Probing the mechanistic role of the long α-helix in subunit L of respiratory Complex I from Escherichia coli by site-directed mutagenesis

(2011) Galina Belevich et al.   MOLECULAR MICROBIOLOGY

Structure of the membrane domain of respiratory complex I

(2011) Rouslan G. Efremov et al.   NATURE

Small single transmembrane domain (STMD) proteins organize the hydrophobic subunits of large membrane protein complexes

(2010) Volker Zickermann et al.   FEBS LETTERS

A new hypothesis on the simultaneous direct and indirect proton pump mechanisms in NADH-quinone oxidoreductase (complex I)

(2010) Tomoko Ohnishi et al.   FEBS LETTERS

Evolution of Respiratory Complex I

(2010) Chui-ying Yip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Membrane Subunit NuoL(ND5) Is Involved in the Indirect Proton Pumping Mechanism ofEscherichia coliComplex I

(2010) Eiko Nakamaru-Ogiso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Site Mutations in the Hetero-oligomeric Mrp Antiporter from AlkaliphilicBacillus pseudofirmusOF4 That Affect Na+/H+Antiport Activity, Sodium Exclusion, Individual Mrp Protein Levels, or Mrp Complex Formation

(2010) Masato Morino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality

(2010) Richard B. Cooley et al.   JOURNAL OF MOLECULAR BIOLOGY

The architecture of respiratory complex I

(2010) Rouslan G. Efremov et al.   NATURE

Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance

(2010) M. M. Roessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria

(2010) I. N. Watt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of membrane proteins

(2010) Kutti R. Vinothkumar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

(2010) C. Hunte et al.   SCIENCE

Structural Basis for the Mechanism of Respiratory Complex I

(2009) John M. Berrisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unlocking the molecular secrets of sodium-coupled transporters

(2009) Harini Krishnamurthy et al.   NATURE

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Chemical and NADH-Induced, ROS-Dependent, Cross-Linking between Subunits of Complex I fromEscherichia coliandThermus thermophilus†

(2008) John M. Berrisford et al.   BIOCHEMISTRY

Three-dimensional structure of respiratory complex I from Escherichia coli in ice in the presence of nucleotides

(2008) David J. Morgan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protons and how they are transported by proton pumps

(2008) M. J. Buch-Pedersen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Real-time electron transfer in respiratory complex I

(2008) M. L. Verkhovskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA