Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

(2020) Adrian F. Gombart et al.   Nutrients

Association between regional selenium status and reported outcome of COVID-19 cases in China

(2020) Jinsong Zhang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

COVID ‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin

(2020) Theoharis C. Theoharides   BIOFACTORS

Nutritional management in hospital setting during SARS-CoV-2 pandemic: a real-life experience

(2020) Marco Cintoni et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

An anti-oxidative therapy for ameliorating cardiac injuries of critically ill COVID-19-infected patients

(2020) Jing-Zhang Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Omega-3 fatty acids in contrast to omega-6 protect against pneumococcal pneumonia

(2020) Cecilia A. Hinojosa et al.   MICROBIAL PATHOGENESIS

The impact of Mediterranean Diet on duration of admission, medical expenses and mortality in elderly, hospitalized patients: A 2-year observational study

(2020) Christos E Lampropoulos et al.   NUTRITION

Challenges at the Time of COVID-19: Opportunities and Innovations in Antivirals from Nature

(2020) Andreas Hensel et al.   PLANTA MEDICA

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

(2020) Liang Chen et al.   Nutrients

COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation

(2020) Ioannis Zabetakis et al.   Nutrients

25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2

(2020) Antonio D’Avolio et al.   Nutrients

Low serum 25‐hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID‐19 are associated with greater disease severity

(2020) Grigorios Panagiotou et al.   CLINICAL ENDOCRINOLOGY

Micronutrients as immunomodulatory tools for COVID-19 management

(2020) Amin Gasmi et al.   CLINICAL IMMUNOLOGY

Nutritional status of patients with coronavirus disease 2019 (COVID-19)

(2020) Jae Hyoung Im et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Evaluation of Nutrition Risk and Its Association With Mortality Risk in Severely and Critically Ill COVID‐19 Patients

(2020) Xiaobo Zhao et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey

(2020) Laura Di Renzo et al.   Journal of Translational Medicine

Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: could they help against COVID-19?

(2020) Hira Shakoor et al.   MATURITAS

Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol

(2020) Riccardo Caccialanza et al.   NUTRITION

Changes in Dietary Behaviours during the COVID-19 Outbreak Confinement in the Spanish COVIDiet Study

(2020) Celia Rodríguez-Pérez et al.   Nutrients

Covid-19 Confinement and Changes of Adolescent’s Dietary Trends in Italy, Spain, Chile, Colombia and Brazil

(2020) María Belén Ruiz-Roso et al.   Nutrients

Nutrients in prevention, treatment, and management of viral infections; special focus on Coronavirus

(2020) Fatemeh BourBour et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Key Aspects in Nutritional Management of COVID-19 Patients

(2020) Alfredo Fernández-Quintela et al.   Journal of Clinical Medicine

The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study

(2020) Jonathan Hewitt et al.   Lancet Public Health

May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients?

(2020) Pierre Weill et al.   BIOCHIMIE

Coronavirus 2019, Microthromboses, and Platelet Activating Factor

(2020) Theoharis C. Theoharides et al.   CLINICAL THERAPEUTICS

Selenium supplementation in the prevention of coronavirus infections (COVID-19)

(2020) Marek Kieliszek et al.   MEDICAL HYPOTHESES

Antiviral Functional Foods and Exercise Lifestyle Prevention of Coronavirus

(2020) Ahmad Alkhatib   Nutrients

Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region

(2020) María-Teresa García-Conesa et al.   Nutrients

Exploitation of some natural products for prevention and/or nutritional treatment of SARS-CoV2 infection

(2020) Annalisa Rizzo et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Mediterranean Diet and COVID-19: Hypothesizing Potential Benefits in People With Diabetes

(2020) Maria Ida Maiorino et al.   Frontiers in Endocrinology

The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections

(2020) Alexander Panossian et al.   Pharmaceuticals

Thrombosis and COVID-19: The Potential Role of Nutrition

(2020) Alexandros Tsoupras et al.   Frontiers in Nutrition

Yoghurt fermentation alters the composition and antiplatelet properties of milk polar lipids

(2020) Ronan Lordan et al.   FOOD CHEMISTRY

Associations between red blood cells fatty acids, desaturases indices and metabolism of platelet activating factor in healthy volunteers

(2020) E. Fragopoulou et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

(2020) Jean Bousquet et al.   Clinical and Translational Allergy

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

(2019) Bingpeng Yan et al.   Viruses-Basel

The effect of ovine milk fermentation on the antithrombotic properties of polar lipids

(2019) Ronan Lordan et al.   Journal of Functional Foods

Stingless bee honey protects against lipopolysaccharide induced-chronic subclinical systemic inflammation and oxidative stress by modulating Nrf2, NF-κB and p38 MAPK

(2019) Yazan Ranneh et al.   Nutrition & Metabolism

Consumption of plant extract supplement reduces platelet activating factor-induced platelet aggregation and increases platelet activating factor catabolism: a randomised, double-blind and placebo-controlled trial

(2019) Lamprini Gavriil et al.   BRITISH JOURNAL OF NUTRITION

Adherence to Mediterranean Diet, Malnutrition, Length of Stay and Mortality in Elderly Patients Hospitalized in Internal Medicine Wards

(2019) Aurelio Lo Buglio et al.   Nutrients

γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice

(2019) Wiramon Rungratanawanich et al.   Nutrients

Effects of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) on Atherogenic Lipid/Lipoprotein, Apolipoprotein, and Inflammatory Parameters in Patients With Elevated High-Sensitivity C-Reactive Protein (from the ANCHOR Study)

(2019) Michael Miller et al.   AMERICAN JOURNAL OF CARDIOLOGY

Low vitamin D levels are associated with high viral loads in patients with chronic hepatitis B: a systematic review and meta-analysis

(2019) Ye-Chao Hu et al.   BMC GASTROENTEROLOGY

Effects of postprandial hydroxytyrosol and derivates on oxidation of LDL, cardiometabolic state and gene expression

(2019) Marco A. Perrone et al.   Journal of Cardiovascular Medicine

Icosapent ethyl reduces atherogenic markers in high-risk statin-treated patients with stage 3 chronic kidney disease and high triglycerides

(2019) Krishnaswami Vijayaraghavan et al.   POSTGRADUATE MEDICINE

Platelet-Activating Factor (PAF) in Allergic Rhinitis: Clinical and Therapeutic Implications

(2019) Rosa M. Muñoz-Cano et al.   Journal of Clinical Medicine

Zinc Homeostasis in Platelet-Related Diseases

(2019) Elmina Mammadova-Bach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis

(2019) Mohammad et al.   Biomolecules

Investigation of phenolic compounds, antioxidant and anti-inflammatory activities in stingless bee honey (Meliponinae)

(2019) Fabíola Carina Biluca et al.   FOOD RESEARCH INTERNATIONAL

Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease

(2019) Lunyu Yi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives

(2019) Ronan Lordan et al.   MOLECULES

Mediterranean diet and platelet-activating factor; a systematic review

(2018) Tzortzis Nomikos et al.   CLINICAL BIOCHEMISTRY

Selenium, Selenoproteins, and Immunity

(2018) Joseph Avery et al.   Nutrients

Vitamin A Deficiency and the Lung

(2018) Joaquín Timoneda et al.   Nutrients

Curcumin, hemostasis, thrombosis, and coagulation

(2017) Faeze Keihanian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study

(2017) Conor P. Kerley et al.   Journal of Clinical Sleep Medicine

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

(2017) Pinar Soysal et al.   MATURITAS

Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes

(2017) Chrysa Argyrou et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Diet and Asthma: Is It Time to Adapt Our Message?

(2017) Laurent Guilleminault et al.   Nutrients

Vitamin C and Immune Function

(2017) Anitra Carr et al.   Nutrients

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus

(2017) Ángela Vázquez-Calvo et al.   Frontiers in Microbiology

Modulation of platelet functions by crude rice (Oryza sativa) bran policosanol extract

(2016) Wai-Teng Wong et al.   BMC Complementary and Alternative Medicine

Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men

(2016) Marianna N. Xanthopoulou et al.   EUROPEAN JOURNAL OF NUTRITION

The Yin and Yang of copper during infection

(2016) Angelique N. Besold et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular disease risk factors: a randomized clinical trial

(2016) Ivor B. Asztalos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Macronutrient content and food exchanges for 48 Greek Mediterranean dishes

(2016) Paraskevi Detopoulou et al.   Nutrition & Dietetics

New Risk Factors for Adult-Onset Incident Asthma. A Nested Case–Control Study of Host Antioxidant Defense

(2015) Emma K. Larkin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Adherence to Mediterranean diet and 10-year incidence (2002-2012) of diabetes: correlations with inflammatory and oxidative stress biomarkers in the ATTICA cohort study

(2015) E. Koloverou et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials

(2015) S Saboori et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Dose-response effects of marine omega-3 fatty acids on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and Lp-PLA2 in individuals with moderate hypertriglyceridemia

(2015) Ann C. Skulas-Ray et al.   Journal of Clinical Lipidology

Vitamin D supplementation and antibacterial immune responses in adolescents and young adults with HIV/AIDS

(2015) Rene F. Chun et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Effects of omega-3 carboxylic acids on lipoprotein particles and other cardiovascular risk markers in high-risk statin-treated patients with residual hypertriglyceridemia: a randomized, controlled, double-blind trial

(2015) Richard L. Dunbar et al.   Lipids in Health and Disease

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

(2015) Swapna Upadhyay et al.   Oxidative Medicine and Cellular Longevity

Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions

(2015) Ioanna C. Vlachogianni et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The relation of diet with PAF and its metabolic enzymes in healthy volunteers

(2014) P. Detopoulou et al.   EUROPEAN JOURNAL OF NUTRITION

Effect of Robola and Cabernet Sauvignon extracts on platelet activating factor enzymes activity on U937 cells

(2014) M.N. Xanthopoulou et al.   FOOD CHEMISTRY

Whether vitamin A supplementation is effective in T-bet and IFN-ɣ gene expression reduction?

(2014) Hashem Sezavar et al.   IMMUNOLOGICAL INVESTIGATIONS

Replacing with whole grains and legumes reduces Lp-PLA2activities in plasma and PBMCs in patients with prediabetes or T2D

(2014) Minjoo Kim et al.   JOURNAL OF LIPID RESEARCH

n-3 PUFA Esterified to Glycerol or as Ethyl Esters Reduce Non-Fasting Plasma Triacylglycerol in Subjects with Hypertriglyceridemia: A Randomized Trial

(2014) Anne Hedengran et al.   LIPIDS

Chloroquine Is a Zinc Ionophore

(2014) Jing Xue et al.   PLoS One

The role of prostaglandins in allergic lung inflammation and asthma

(2014) Dru Claar et al.   Expert Review of Respiratory Medicine

Antimicrobial activity and rutin identification of honey produced by the stingless bee Melipona compressipes manaosensis and commercial honey

(2013) Renah Boanerges de Queiroz Pimentel et al.   BMC Complementary and Alternative Medicine

Dietary supplementation with omega-3 polyunsaturated fatty acids ameliorates acute pneumonia induced by Klebsiella pneumoniae in BALB/c mice

(2013) Sonica Sharma et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Effects of icosapent ethyl on lipid and inflammatory parameters in patients with diabetes mellitus-2, residual elevated triglycerides (200–500 mg/dL), and on statin therapy at LDL-C goal: the ANCHOR study

(2013) Eliot A Brinton et al.   Cardiovascular Diabetology

Paricalcitol Effects on Activities and Metabolism of Platelet Activating Factor and on Inflammatory Cytokines in Hemodialysis Patients

(2013) Sophia N. Verouti et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: The EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial

(2013) John J.P. Kastelein et al.   Journal of Clinical Lipidology

Intensive Lifestyle Modification Reduces Lp-PLA2 in Dyslipidemic HIV/HAART Patients

(2013) JOSHUA S. WOOTEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Polyunsaturated omega-3 fatty acids reduce lipoprotein-associated phospholipase A2 in patients with stable angina

(2013) Grzegorz Gajos et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Fatty acids and TxA2 generation, in the absence of platelet-COX-1 activity

(2013) A.P. DeFilippis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study)

(2012) Christie M. Ballantyne et al.   AMERICAN JOURNAL OF CARDIOLOGY

PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils

(2012) Luis Alexandre Muehlmann et al.   RESEARCH IN VETERINARY SCIENCE

Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial)

(2011) Harold E. Bays et al.   AMERICAN JOURNAL OF CARDIOLOGY

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

(2011) Zhi Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

PAF effects on MCP-1 and IL-6 secretion in U-937 monocytes in comparison with OxLDL and IL-1β effects

(2011) Sophia N. Verouti et al.   ATHEROSCLEROSIS

Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia

(2011) Kevin C. Maki et al.   Journal of Clinical Lipidology

Fish polar lipids retard atherosclerosis in rabbits by down-regulating PAF biosynthesis and up-regulating PAF catabolism

(2011) Constantina Nasopoulou et al.   Lipids in Health and Disease

Mediterranean wild plants reduce postprandial platelet aggregation in patients with metabolic syndrome

(2011) Elizabeth Fragopoulou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Selenium and asthma

(2011) Robert L. Norton et al.   MOLECULAR ASPECTS OF MEDICINE

In Vitro and In Vivo Effects of Statins on Platelet-Activating Factor and Its Metabolism

(2010) Nektaria Tsantila et al.   ANGIOLOGY

Structurally Diverse Metal Coordination Compounds, Bearing Imidodiphosphinate and Diphosphinoamine Ligands, as Potential Inhibitors of the Platelet Activating Factor

(2010) Alexandros B. Tsoupras et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Protection from H1N1 Influenza Virus Infections in Mice by Supplementation with Selenium: A Comparison with Selenium-Deficient Mice

(2010) Lei Yu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Trends in adherence to the Mediterranean diet in an Italian population between 1991 and 2006

(2010) C Pelucchi et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Fish Oil-Fed Mice Have Impaired Resistance to Influenza Infection

(2009) Nicole M. J. Schwerbrock et al.   JOURNAL OF NUTRITION

Studies on HDL associated enzymes under experimental hypercholesterolemia: possible modulation on selenium supplementation

(2009) Harman D Kaur et al.   Lipids in Health and Disease

Anti-Platelet-Activating Factor Effects of Highly Active Antiretroviral Therapy (HAART): A New Insight in the Drug Therapy of HIV Infection?

(2008) Alexandros B. Tsoupras et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study

(2008) S. Tsimikas et al.   EUROPEAN HEART JOURNAL

The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults

(2008) Maria Weinkouff Pedersen et al.   EUROPEAN JOURNAL OF NUTRITION

Antibacterial and anti-PAF activity of lipid extracts from sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata)

(2008) Constantina Nasopoulou et al.   FOOD CHEMISTRY

BIOACTIVE POLAR LIPIDS IN OLIVE OIL, POMACE AND WASTE BYPRODUCTS

(2008) HARALABOS C. KARANTONIS et al.   JOURNAL OF FOOD BIOCHEMISTRY

Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity

(2008) Joline W.J. Beulens et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids

(2006) Erik Berg Schmidt et al.   ATHEROSCLEROSIS