Journal
FOOD CHEMISTRY
Volume 165, Issue -, Pages 50-59Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.05.085
Keywords
Resveratrol; Quercetin; Wine; Platelet activating factor metabolism; Atherosclerosis
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A number of studies support the anti-atherogenic effect of wine compounds. The scope of this study was to examine the effect of a red (Cabernet Sauvignon-CS) and a white (Robola R) wine, as well as resveratrol and quercetin, on the platelet activating factor (PAP) biosynthetic enzymes, acetyl-CoA: lyso-PAF acetyltransferase (lyso-PAF-AT) and DTT-insensitive CDP-choline 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT), and its main catabolic enzyme (PAP acetylhydrolase; PAF-AH), on U937 cells, in cell free and in intact cell experiments. In cell free experiments, phenolic compounds and wine extracts inhibited PAP biosynthetic enzymes, however in higher concentrations than intact cell experiments. In the latter cases, polar lipids of both wines inhibited in the same order of magnitude the action of lyso-PAF-AT and of PAF-CPT. The water fractions possessed a dual action, in lower concentrations they activated both enzymes, while in higher concentrations only inhibited PAF-CPT. All fractions either did not affect or slightly activated PAF-AH activity. In conclusion, wine compounds may exert their anti-inflammatory activity by reducing PAP levels through modulation of the PAF metabolic enzymes. (C) 2014 Elsevier Ltd. All rights reserved.
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