Article
Medicine, General & Internal
Cristian Locci, Antonella Ruiu, Laura Saderi, Giovanni Sotgiu, Stefania Bassu, Marco Zaffanello, Roberto Antonucci
Summary: The prevalence of hypovitaminosis D is increasing worldwide, and its relationship with pediatric obstructive sleep apnea syndrome (OSAS) is still not fully understood. This retrospective study investigated the vitamin D status in pediatric patients with OSAS and assessed the relationship between serum vitamin D levels and OSAS severity. The results showed that OSAS patients had significantly lower vitamin D levels compared to controls, and severe cases of OSAS had lower vitamin D levels than mild and moderate cases. Further prospective studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Andras Bikov, Sebastien Bailly, Dries Testelmans, Francesco Fanfulla, Athanasia Pataka, Izolde Bouloukaki, Holger Hein, Zoran K. Dogas, Ozen Basoglu, Richard Staats, Gianfranco Parati, Carolina Lombardi, Ludger Grote, Stefan Mihaicuta, ESADA Study Grp
Summary: Periodic limb movements during sleep may be an additional risk factor for cardiovascular disease in patients with obstructive sleep apnea, as it is associated with dyslipidemia. This study aimed to determine the impact of periodic limb movements during sleep on serum lipid levels in obstructive sleep apnea patients.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ante Mihovilovic, Zoran Dogas, Dinko Martinovic, Daria Tokic, Ema Puizina Mladinic, Marko Kumric, Natalija Ivkovic, Marino Vilovic, Josko Bozic
Summary: Obstructive sleep apnea (OSA) is a major public concern and this study aimed to evaluate serum Urotensin II (UII) levels in OSA patients and controls. The study included 89 OSA patients and 89 controls, and UII levels as well as other parameters were assessed. The OSA group had higher levels of hsCRP and serum UII compared to the control group, and there was a positive correlation between UII levels and hsCRP and systolic blood pressure. Multiple regression analysis showed significant associations of UII levels with AHI, SBP, and hsCRP. These findings suggest that UII may play a role in the complex pathophysiology of OSA and its cardiometabolic complications.
Article
Nutrition & Dietetics
Surya Prakash Bhatt, Randeep Guleria
Summary: The study found that obese patients with OSA had lower serum vitamin D levels, which correlated with disease severity. Variations in VDR and PTH genes were highly associated with OSA in Asian Indians.
Article
Medicine, General & Internal
Feride Ayyildiz, Hilal Yildiran, Nigar Afandiyeva, Ozlem Gulbahar, Oguz Kokturk
Summary: The study found that vitamin D supplementation has a positive effect on the disease prognosis and biochemical parameters of patients with mild OSAS, leading to a significant increase in serum vitamin D levels and a decrease in blood glucose, cholesterol, and other biochemical parameters. Additionally, it was shown to alleviate symptoms of sleep apnea.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Immunology
Minhan Yi, Wangcheng Zhao, Quanming Fei, Yun Tan, Kun Liu, Ziliang Chen, Yuan Zhang
Summary: This study found that the levels of interleukins were altered in obstructive sleep apnea (OSA), but the MR analysis did not identify significant causal relationships between these interleukins.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marija Zdravkovic, Viseslav Popadic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Anica Divac, Andrea Manojlovic, Novica Nikolic, Filip Lukic, Esma Rasiti, Katarina Mircetic, Djordje Marinkovic, Sofija Nikolic, Bogdan Crnokrak, Danica Popovic Lisulov, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Ratko Lasica, Biljana Parapid, Predrag Djuran, Milica Brajkovic
Summary: This study found that lipid abnormalities and inflammation play an important role in the development of cardiovascular risk in patients with OSA, and emphasized the importance of obesity as a common comorbidity in these patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Izolde Bouloukaki, Ioanna Tsiligianni, Charalampos Mermigkis, Marisa R. Bonsignore, Manolis Markakis, Athanasia Pataka, Paschalis Steiropoulos, Christina Ermidou, Ioanna Alexaki, Nikolaos Tzanakis, Sophia Schiza
Summary: A large proportion of OSA patients were found to have vitamin D deficiency, especially in severe cases. Severe OSA showed significant independent associations with the risk of vitamin D deficiency. However, further research is needed to determine the role of vitamin D in OSA patients.
SLEEP AND BREATHING
(2021)
Article
Pediatrics
Pietro De Luca, Arianna Di Stadio, Pasquale Marra, Francesca Atturo, Alfonso Scarpa, Claudia Cassandro, Ignazio La Mantia, Antonio Della Volpe, Luca de Campora, Domenico Tassone, Angelo Camaioni, Ettore Cassandro
Summary: This study compared the serum vitamin D levels of pediatric non-allergic patients with obstructive sleep apnea (OSA) and healthy controls, and found that the patients had significantly lower levels of 25-hydroxy vitamin D. The study suggests that vitamin D deficiency may have a negative effect on the immune system.
Review
Medicine, General & Internal
Pei-Kang Liu, Tzu-Yu Chiu, Nan-Kai Wang, Sarah R. Levi, Ming-Ju Tsai
Summary: Obstructive sleep apnea (OSA) is a common sleep disorder that can lead to ocular consequences, clinicians should understand the eye diseases in patients with OSA and provide comprehensive care.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Maria Carmina Pau, Angelo Zinellu, Arduino A. Mangoni, Panagiotis Paliogiannis, Maria Roberta Lacana, Sara Solveig Fois, Sabrina Mellino, Alessandro G. Fois, Ciriaco Carru, Elisabetta Zinellu, Pietro Pirina
Summary: In this study of 259 OSA patients, specific haematological parameters such as albumin, neutrophil and monocyte counts, and the systemic inflammatory response index were found to be associated with reduced oxygen saturation. These findings suggest that these parameters may serve as promising markers for assessing oxygen saturation in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Michelle A. Miller, Francesco P. Cappuccio
Summary: This study reviewed the relationship between OSA and COVID-19 outcomes, finding that risk factors associated with OSA are also linked to poor COVID-19 outcomes. Plausible mechanisms suggest OSA may independently increase the risk of death from COVID-19. The study also highlights the major impact of COVID-19 on the diagnosis and treatment of OSA.
SLEEP MEDICINE REVIEWS
(2021)
Review
Otorhinolaryngology
Chia-Hsuan Lee, Wei-Chung Hsu, Te-Huei Yeh, Jenq-Yuh Ko, Ming-Tzer Lin, Kun-Tai Kang
Summary: Sleep surgery may have a positive impact on the lipid profile of adults with obstructive sleep apnea, and the improvement in lipid profile is positively correlated with the degree of improvement in sleep apnea.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Cardiac & Cardiovascular Systems
Conor P. Kerley, James O. O'Neill, Venu Reddy Bijjam, Ciara Blaine, Philip E. James, Liam Cormican
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2016)
Article
Medicine, General & Internal
C. P. Kerley, E. Dolan, L. Cormican
IRISH JOURNAL OF MEDICAL SCIENCE
(2017)
Review
Critical Care Medicine
David A. Jolliffe, Lauren Greenberg, Richard L. Hooper, Christopher J. Griffiths, Carlos A. Camargo, Conor P. Kerley, Megan E. Jensen, David Mauger, Iwona Stelmach, Mitsuyoshi Urashima, Adrian R. Martineau
LANCET RESPIRATORY MEDICINE
(2017)
Article
Nutrition & Dietetics
Conor P. Kerley, Eamon Dolan, Philip E. James, Liam Cormican
BRITISH JOURNAL OF NUTRITION
(2018)
Article
Food Science & Technology
Conor P. Kerley, Philip E. James, Aisling McGowan, John Faul, Liam Cormican
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2019)
Review
Nutrition & Dietetics
Conor P. Kerley
NUTRITION RESEARCH REVIEWS
(2019)
Article
Neurosciences
Conor P. Kerley, Basil Elnazir, Peter Greally, David Coghlan
NUTRITIONAL NEUROSCIENCE
(2020)
Review
Cardiac & Cardiovascular Systems
Tom Butler, Conor P. Kerley, Nunzia Altieri, Joe Alvarez, Jane Green, Julie Hinchliffe, Dell Stanford, Katherine Paterson
Letter
Medicine, General & Internal
Conor P. Kerley
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Allergy
K. Hutchinson, C. P. Kerley, J. Faul, P. Greally, D. Coghlan, M. Louw, B. Elnazir, Y. Rochev
EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Review
Endocrinology & Metabolism
Conor P. Kerley
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2017)
Article
Pediatrics
Conor P. Kerley, Clare Power, Louise Gallagher, David Coghlan
ARCHIVES OF DISEASE IN CHILDHOOD
(2017)
Article
Health Care Sciences & Services
Adrian R. Martineau, David A. Jolliffe, Lauren Greenberg, John F. Aloia, Peter Bergman, Gal Dubnov-Raz, Susanna Esposito, Davaasambuu Ganmaa, Adit A. Ginde, Emma C. Goodall, Cameron C. Grant, Wim Janssens, Megan E. Jensen, Conor P. Kerley, Ilkka Laaksi, Semira Manaseki-Holland, David Mauger, David R. Murdoch, Rachel Neale, Judy R. Rees, Steve Simpson, Iwona Stelmach, Geeta Trilok Kumar, Mitsuyoshi Urashima, Carlos A. Camargo, Christopher J. Griffiths, Richard L. Hooper
HEALTH TECHNOLOGY ASSESSMENT
(2019)
Letter
Respiratory System
Conor P. Kerley
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2018)