Vitamin C and Immune Function

Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials

(2017) A W Ashor et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

The role of vitamin C in the treatment of pain: new insights

(2017) Anitra C. Carr et al.   Journal of Translational Medicine

The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression

(2017) Yu-Lei Gao et al.   MEDIATORS OF INFLAMMATION

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

The role of extracellular histone in organ injury

(2017) Eleanor Silk et al.   Cell Death & Disease

Vitamin C and Infections

(2017) Harri Hemilä   Nutrients

Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus: Associations with Glycaemic Control, Obesity, and Smoking

(2017) Renée Wilson et al.   Nutrients

The Roles of Vitamin C in Skin Health

(2017) et al.   Nutrients

With Friends Like These: The Complex Role of Neutrophils in the Progression of Severe Pneumonia

(2017) Roger D. Pechous   Frontiers in Cellular and Infection Microbiology

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance

(2017) Eirini Nikolouli et al.   Frontiers in Immunology

Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton

(2016) William H. Parker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reactive Oxygen Species and Neutrophil Function

(2016) Christine C. Winterbourn et al.   Annual Review of Biochemistry

Chronic granulomatous disease

(2016) Dirk Roos   BRITISH MEDICAL BULLETIN

Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application

(2016) Giuseppe Valacchi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Vitamin C Facilitates Demethylation of theFoxp3Enhancer in a Tet-Dependent Manner

(2016) Varun Sasidharan Nair et al.   JOURNAL OF IMMUNOLOGY

Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy

(2016) Nina Mikirova et al.   MEDICAL SCIENCE MONITOR

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

Regulation of the Epigenome by Vitamin C

(2015) Juan I. Young et al.   Annual Review of Nutrition

Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes

(2015) Kun Pyo Kim et al.   Biomolecules & Therapeutics

Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy

(2015) Mirelle J.A.J. Huijskens et al.   CYTOTHERAPY

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In the eye of the neutrophil swarm-navigation signals that bring neutrophils together in inflamed and infected tissues

(2015) Tim Lämmermann   JOURNAL OF LEUKOCYTE BIOLOGY

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection

(2015) Giuseppe Valacchi et al.   PLoS One

Vitamin C promotes wound healing through novel pleiotropic mechanisms

(2015) Bassem M Mohammed et al.   International Wound Journal

Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following Dietary Supplementation with Vitamin C-Rich SunGold Kiwifruit

(2015) Stephanie Bozonet et al.   Nutrients

Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus: a pilot study in healthy subjects

(2014) Raffaella Canali et al.   Genes and Nutrition

Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes

(2014) Nathalia Molina et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CD24-Triggered Caspase-Dependent Apoptosis via Mitochondrial Membrane Depolarization and Reactive Oxygen Species Production of Human Neutrophils Is Impaired in Sepsis

(2014) M. Parlato et al.   JOURNAL OF IMMUNOLOGY

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

(2014) Mirelle J. A. J. Huijskens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

(2014) Yuanyuan Chen et al.   MEDIATORS OF INFLAMMATION

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Neutrophil Extracellular Traps in Sepsis

(2014) Gabriela Camicia et al.   SHOCK

Vitamin C Supplementation Slightly Improves Physical Activity Levels and Reduces Cold Incidence in Men with Marginal Vitamin C Status: A Randomized Controlled Trial

(2014) Carol Johnston et al.   Nutrients

Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression

(2014) Caroline Kuiper et al.   Frontiers in Oncology

Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations

(2013) Anitra C Carr et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Innate Immune Functions of Immature Neutrophils in Patients With Sepsis and Severe Systemic Inflammatory Response Syndrome*

(2013) Geneviève Drifte et al.   CRITICAL CARE MEDICINE

Breathing-in epigenetic change with vitamin C

(2013) Asun Monfort et al.   EMBO REPORTS

Fruit and vegetable intake and the association with glucose parameters: a cross-sectional analysis of the Let’s Prevent Diabetes Study

(2013) P Carter et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Macrophages, fat, and the emergence of immunometabolism

(2013) Anthony W. Ferrante   JOURNAL OF CLINICAL INVESTIGATION

Essential Role of Vitamin C and Zinc in Child Immunity and Health

(2013) S Maggini et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Vitamin C Deficiency in a University Teaching Hospital

(2013) Runye Gan et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Vitamin C and A1c Relationship in the National Health and Nutrition Examination Survey (NHANES) 2003–2006

(2013) Jatupol Kositsawat et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases

(2013) Alexander F. Hagel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Dose-Dependent Vitamin C Uptake and Radical Scavenging Activity in Human Skin Measured with in vivo Electron Paramagnetic Resonance Spectroscopy

(2013) Anna-Christina Lauer et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Potential functional roles of DNA demethylation intermediates

(2013) Chun-Xiao Song et al.   TRENDS IN BIOCHEMICAL SCIENCES

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

(2013) Bassem Mohammed et al.   Nutrients

Neutrophils and Wound Repair: Positive Actions and Negative Reactions

(2013) Traci A. Wilgus et al.   Advances in Wound Care

Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection

(2013) Yejin Kim et al.   Immune Network

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid

(2012) Bernard J. Fisher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vitamin C Promotes Maturation of T-Cells

(2012) Jared Manning et al.   ANTIOXIDANTS & REDOX SIGNALING

Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts

(2012) Yuki Kishimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  

(2012) A. M. McInturff et al.   BLOOD

Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT

(2012) Sandra C. Blass et al.   CLINICAL NUTRITION

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(2012) Adnana Paunel-Gorgulu et al.   MOLECULAR MEDICINE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Activation of hypoxia-inducible factor-1  (Hif-1 ) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

(2011) P. M. Elks et al.   BLOOD

Roles of superoxide and myeloperoxidase in ascorbate oxidation in stimulated neutrophils and H2O2-treated HL60 cells

(2011) Amber Parker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors

(2011) Eduardo Tamayo et al.   JOURNAL OF CRITICAL CARE

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vitamin C for DNA damage prevention

(2011) Radim J. Sram et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Dietary ascorbate intake affects steady state tissue concentrations in vitamin C–deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)

(2010) Margreet CM Vissers et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role for Myeloid Nuclear Differentiation Antigen in the Regulation of Neutrophil Apoptosis during Sepsis

(2010) Nasser Fotouhi-Ardakani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Vitamin C requirement in surgical patients

(2010) Ryoji Fukushima et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils

(2010) N. N. McGovern et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

(2010) Sarah Fox et al.   Journal of Innate Immunity

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

(2010) Janesh Pillay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Too old to fight? Aging and its toll on innate immunity

(2010) G. Hajishengallis   Molecular Oral Microbiology

Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES)

(2009) Rosemary L Schleicher et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin C: update on physiology and pharmacology

(2009) J Mandl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disease-Specific, Versus Standard, Nutritional Support for the Treatment of Pressure Ulcers in Institutionalized Older Adults: A Randomized Controlled Trial

(2009) Emanuele Cereda et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Plasma Vitamin C Level, Fruit and Vegetable Consumption, and the Risk of New-Onset Type 2 Diabetes MellitusThe European Prospective Investigation of Cancer–Norfolk Prospective Study

(2008) Anne-Helen Harding   ARCHIVES OF INTERNAL MEDICINE

In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals

(2008) Helen R. Griffiths et al.   BRITISH JOURNAL OF NUTRITION

Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression

(2008) D. D. Danikas et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Air pollution, oxidative stress and dietary supplementation: a review

(2008) I. Romieu et al.   EUROPEAN RESPIRATORY JOURNAL

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gene expression profiling reveals new protective roles for vitamin C in human skin cells

(2008) T DUARTE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of Vitamin C Administration on Neutrophil Apoptosis in Septic Patients After Abdominal Surgery

(2008) Ignacio Ferrón-Celma et al.   JOURNAL OF SURGICAL RESEARCH

Update: Effects of Antioxidant and Non-Antioxidant Vitamin Supplementation on Immune Function

(2008) Aimee L. Webb et al.   NUTRITION REVIEWS

NEUTROPHIL-DERIVED CIRCULATING FREE DNA (cf-DNA/NETs)

(2008) Stefan Margraf et al.   SHOCK

Tobacco use increases susceptibility to bacterial infection

(2008) Juhi Bagaitkar et al.   Tobacco Induced Diseases