Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease

Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer’s disease animal model

(2020) Balázs A. Györffy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets

(2020) Andrea J. Tenner   JOURNAL OF IMMUNOLOGY

Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

(2020) Dibyadeep Datta et al.   Journal of Neuroinflammation

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

(2020) Ashley L. Comer et al.   PLOS BIOLOGY

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

(2020) Souhel Najjar et al.   Journal of Neuroinflammation

Neurological associations of COVID-19

(2020) Mark A Ellul et al.   LANCET NEUROLOGY

Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series

(2020) Sara Radmard et al.   Frontiers in Neurology

The complement system in COVID-19: friend and foe?

(2020) Anuja Java et al.   JCI Insight

Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

(2019) Giovanna De Chiara et al.   PLoS Pathogens

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

(2019) Carl M. Sellgren et al.   NATURE NEUROSCIENCE

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

Intrathecal complement activation by the classical pathway in tick-borne encephalitis

(2019) Malin Veje et al.   JOURNAL OF NEUROVIROLOGY

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

(2019) Charise Garber et al.   NATURE NEUROSCIENCE

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

(2019) Claudia P. Figueiredo et al.   Nature Communications

Ocular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q

(2019) Christina A. Welsh et al.   JOURNAL OF NEUROSCIENCE

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

(2019) Aleksandra Vukojicic et al.   Cell Reports

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

(2018) Jenny U. Johansson et al.   Alzheimers & Dementia

Complement component 3a receptor deficiency attenuates chronic stress-induced monocyte infiltration and depressive-like behavior

(2018) Amanda Crider et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroprotective effect of acute prior inflammation with lipopolysaccharide for adult male rat facial motoneurones

(2018) Viythia Katharesan et al.   BRAIN RESEARCH

Identifying the role of complement in triggering neuroinflammation after traumatic brain injury

(2018) Ali Alawieh et al.   JOURNAL OF NEUROSCIENCE

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1

(2018) Charise Garber et al.   NATURE IMMUNOLOGY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

(2018) Balázs A. Györffy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement: The Emerging Architect of the Developing Brain

(2018) Liam G. Coulthard et al.   TRENDS IN NEUROSCIENCES

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease

(2018) Steven A. Harris et al.   Frontiers in Aging Neuroscience

An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease—A cohort study of 95,442 individuals

(2018) Katrine Laura Rasmussen et al.   Alzheimers & Dementia

HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q

(2018) Jennetta W. Hammond et al.   GLIA

TREM2 triggers microglial density and age‐related neuronal loss

(2018) Bettina Linnartz‐Gerlach et al.   GLIA

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex

(2018) Britta Schiela et al.   Frontiers in Immunology

The Correlation between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer’s Disease

(2017) Angharad R. Morgan et al.   JOURNAL OF ALZHEIMERS DISEASE

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

(2017) Maria I. Fonseca et al.   Journal of Neuroinflammation

Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ

(2017) Liam G. Coulthard et al.   JOURNAL OF NEUROSCIENCE

C1q: A fresh look upon an old molecule

(2017) Nicole M. Thielens et al.   MOLECULAR IMMUNOLOGY

Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury

(2017) Rachna Manek et al.   MOLECULAR NEUROBIOLOGY

Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

(2017) Michael X. Hernandez et al.   Molecular Neurodegeneration

Developing awareness of confabulation through psychological formulation: A case report and first-person perspective

(2017) Jessica Fish et al.   NEUROPSYCHOLOGICAL REHABILITATION

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Serping1/C1 Inhibitor Affects Cortical Development in a Cell Autonomous and Non-cell Autonomous Manner

(2017) Anna Gorelik et al.   Frontiers in Cellular Neuroscience

Deconvolution of Transcriptional Networks in Post-Traumatic Stress Disorder Uncovers Master Regulators Driving Innate Immune System Function

(2017) Abolfazl Doostparast Torshizi et al.   Scientific Reports

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

(2016) Anna Stokowska et al.   BRAIN

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function

(2016) Rickard P.F. Lindblom et al.   CLINICAL IMMUNOLOGY

Complement Biomarkers as Predictors of Disease Progression in Alzheimer’s Disease

(2016) Svetlana Hakobyan et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

The complement system, neuronal injury, and cognitive function in horizontally-acquired HIV-infected youth

(2016) Jennifer L. McGuire et al.   JOURNAL OF NEUROVIROLOGY

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis

(2016) Hamid Salimi et al.   Neurotherapeutics

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease

(2016) William T. Hu et al.   Acta Neuropathologica Communications

Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

(2016) Maria I. Fonseca et al.   PLoS One

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury

(2015) F. H. Brennan et al.   JOURNAL OF NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis

(2015) Shahin Aeinehband et al.   PLoS One

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning

(2013) Adriana del Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Targeting complement component 5a promotes vascular integrity and limits airway remodeling

(2013) M. A. Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

West Nile Virus: Biology, Transmission, and Human Infection

(2012) T. M. Colpitts et al.   CLINICAL MICROBIOLOGY REVIEWS

Interaction of HmC1q with leech microglial cells: involvement of C1qBP-related molecule in the induction of cell chemotaxis

(2012) Muriel Tahtouh et al.   Journal of Neuroinflammation

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration

(2011) Carlos Carmona-Fontaine et al.   DEVELOPMENTAL CELL

Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection

(2011) C. B. Brooke et al.   JOURNAL OF GENERAL VIROLOGY

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

West Nile Virus: Immunity and Pathogenesis

(2011) Stephanie M. Lim et al.   Viruses-Basel

IFN-  Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid   Precursor Protein Transgenic Mice

(2010) P. Chakrabarty et al.   JOURNAL OF IMMUNOLOGY

The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children

(2010) Gehan A. Mostafa et al.   JOURNAL OF NEUROIMMUNOLOGY

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Present and future arboviral threats

(2009) Scott C. Weaver et al.   ANTIVIRAL RESEARCH

Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage

(2009) Matthew C. Garrett et al.   BRAIN RESEARCH

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

C3aR inhibition reduces neurodegeneration in experimental lupus

(2009) A. Jacob et al.   LUPUS

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

(2008) Ruth M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s disease

(2008) Jun Zhou et al.   JOURNAL OF NEUROCHEMISTRY

The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis

(2007) Paul R. Giacomin et al.   MOLECULAR IMMUNOLOGY