Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

(2017) Hetal Pandya et al.   NATURE NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

(2017) Chao Wang et al.   Stem Cell Reports

Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [ 11 C]PBR28 study

(2017) Sudhakar Selvaraj et al.   SCHIZOPHRENIA RESEARCH

Microglia engulf viable newborn cells in the epileptic dentate gyrus

(2016) Cong Luo et al.   GLIA

Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives

(2016) Fabian Oceguera-Yanez et al.   METHODS

Modeling synaptogenesis in schizophrenia and autism using human iPSC derived neurons

(2016) Christa W. Habela et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors

(2016) C M Sellgren et al.   MOLECULAR PSYCHIATRY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy

(2016) Diana S. Balekian et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia

(2016) S Giovanoli et al.   Translational Psychiatry

Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study

(2016) V M Castro et al.   Translational Psychiatry

Validation of Electronic Health Record Phenotyping of Bipolar Disorder Cases and Controls

(2015) Victor M. Castro et al.   AMERICAN JOURNAL OF PSYCHIATRY

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

(2015) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro

(2015) P. Kirwan et al.   DEVELOPMENT

Antidepressant Nonadherence in Routine Clinical Settings Determined From Discarded Blood Samples

(2015) Ashlee M. Roberson et al.   JOURNAL OF CLINICAL PSYCHIATRY

Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study

(2015) Victor M Castro et al.   NEUROPSYCHOPHARMACOLOGY

How Schizophrenia Develops: Cognitive and Brain Mechanisms Underlying Onset of Psychosis

(2015) Tyrone D. Cannon   TRENDS IN COGNITIVE SCIENCES

Identifying and mitigating biases in EHR laboratory tests

(2014) Rimma Pivovarov et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

SynPAnal: Software for Rapid Quantification of the Density and Intensity of Protein Puncta from Fluorescence Microscopy Images of Neurons

(2014) Eric Danielson et al.   PLoS One

Prefrontal Cortical Dendritic Spine Pathology in Schizophrenia and Bipolar Disorder

(2014) Glenn T. Konopaske et al.   JAMA Psychiatry

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

Antidepressant Response in Patients With Major Depression Exposed to NSAIDs: A Pharmacovigilance Study

(2012) Patience J. Gallagher et al.   AMERICAN JOURNAL OF PSYCHIATRY

Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening

(2012) James A Daniel et al.   Nature Protocols

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Dendritic spine pathology in schizophrenia

(2012) J.R. Glausier et al.   NEUROSCIENCE

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

(2011) Steven D. Sheridan et al.   PLoS One

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

(2011) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

(2011) Zdravko Petanjek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model

(2011) R. H. Perlis et al.   PSYCHOLOGICAL MEDICINE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Progressive Structural Brain Changes During Development of Psychosis

(2010) Tim B. Ziermans et al.   SCHIZOPHRENIA BULLETIN

Progressive Gray Matter Reduction of the Superior Temporal Gyrus During Transition to Psychosis

(2009) Tsutomu Takahashi et al.   ARCHIVES OF GENERAL PSYCHIATRY

A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester

(2009) Michael Miksa et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

(2009) K. E. Stephan et al.   SCHIZOPHRENIA BULLETIN

Progressive brain structural changes mapped as psychosis develops in ‘at risk’ individuals

(2009) Daqiang Sun et al.   SCHIZOPHRENIA RESEARCH

Human neural progenitor cells derived from embryonic stem cells in feeder-free cultures

(2008) Sujoy K. Dhara et al.   DIFFERENTIATION

Reductions in frontal, temporal and parietal volume associated with the onset of psychosis

(2008) S BORGWARDT et al.   SCHIZOPHRENIA RESEARCH